岐阜薬科大学
生体機能解析学大講座 薬効解析学研究室

一般論文

2025年

  1. Kumagai M., Egashira Y., Sasaki N., Nakamura S., Kuse Y., Matsubara H., Enomoto Y., Izumo T., Hara H., Shimazawa M.
    Microthrombosis at the Ultra-early Stages after Experimental Subarachnoid Hemorrhage Results in Early Brain Injury
    Current Neurovascular Research, in press
  2. Shimizu H., Tanaka H., Tazaki A., Yamada K., Suzumura M., Ota J., Ushio-Watanabe N., Zheng H., Kataoka K., Hara H., Nishikawa Y., Yasukawa T., Suzuma K., Terasaki H., Nishiguchi K., Kato M., Toyokuni S., Kaneko H.
    Silicone oil, an intraocular surgical adjuvant, induces retinal ferroptosis
    Free Radical Biology and Medicine, 228, 16, 33-45 (2025) 論文PDFはこちら
  3. Araki T., Shimazawa M., Nakamura S., Otsu W., Numata Y., Sakata M., Kabayama K., Tsusaki H., Hara H.
    Macular white dot lesions with hyperreflective optical coherence tomography findings in cynomolgus and rhesus monkeys
    Molecular Vision, in press.

2024年

  1. Chinen N., Otsu W., Kuse Y., Nakamura S., Hara H., Shimazawa M.
    NAMPT activator P7C3-A20 protects against tunicamycin-induced cell injury in C2C12 murine myoblast cells
    BPB Reports, 7, 6, 211-217 (2024).
  2. Tsuji S.#, Hatano R.#, Nakamura S., Kudo U., Aoshima K., Fujimori H., Takagi Y., Obayashi M., Ito T., Yamazoe E., KuseY., Otsu W., Shimazawa M., Tahara K.
    (#Contributed equally)
    Intranasal administration of liposomes can deliver drugs to the posterior ophthalmic region in addition to the brain
  3. Carolina E., Kuse Y., Okumura A., Aoshima K., Tadokoro T., Matsumoto S., Kanai E., Okumura T., Kasai T., Yamabe S., Nishikawa Y., Yamaguchi K., Furukawa Y., Tanimizu N., Taniguchi H.
    Generation of human iPSC-derived 3D bile duct within liver organoid by incorporating human iPSC-derived blood vessel.
  4. Tsuji S., Kudo U., Takahashi K., Nakamura S., Shimazawa M.
    The role of progranulin in macrophages of a glioblastoma model
  5. Tadokoro T., Murata S., Kato M., Ueno Y., Tsuchida T., Okumura A., Kuse Y., Konno T., Uchida Y., Yamakawa Y., Zushi M., Yajima M., Kobayashi T., Hasegawa S., Kawakatsu-Hatada Y., Hayashi Y., Osakabe S., Maeda T., Kimura K., Mori A., Tanaka M., Kobayashi T., Kamishibahara Y., Matsuo M., Nie YZ., Okamoto S., Oba T.,Taminizu N., Taniguchi H.
    Human iPSC-liver organoid transplantation reduces fibrosis through immunomodulation.
    Science Translational Medicine, 16, 757 (2024).
  6. Tanaka M., Yasuda H., Nakamura S., Shimazawa M.
    H-151, a selective STING inhibitor, has potential as a treatment for neovascular age-related macular degeneration
    Investigative Ophthalmology & Visual Science, 65, 16 (2024).
  7. Kuriyama A.#, Nakamura S.#, Inokuchi Y., Abe H., Yasuda H., Hidaka Y., Nagaoka K., Soeda T., Shimazawa M., Hara H. (#Contributed equally)
    The protective effect of anti-VEGF-A/Ang-2 bispecific antibody on retinal vein occlusion model mice
    European Journal of Pharmacology, 976, 176691 (2024).
  8. Nakamura S., Yamamoto R., Matsuda T., Yasuda H., Nishinaka A., Takahashi K., Inoue Y., Kuromitsu S., Shimazawa M., Goto M., Narumiya S., Hara H.
    Sphingosine-1-phosphate receptor 1/5 selective agonist alleviates ocular vascular pathologies
    Scientific reports, 14, 9700 (2024).
  9. Tsuji S., Kudo U., Hatakeyama R., Shoda K., Nakamura S., Shimazawa M.
    Linagliptin decreased the tumor progression on glioblastoma model
    Biochemical and Biophysical Research Communications, 711,     149897 (2024).
  10. Muramatsu A., Nakamura S., Hirayama T., Nagasawa H., Ohira A., Kitaoka T., Hara H., Shimazawa M.
    Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation
  11. Yasuda H., Moriguchi M., YakoT., NakamuraS., Shimazawa M., Hara H.
    GPR35, a new therapeutic target for atrophic age-related macular degeneration
    BPB Report, 7, 14-20 (2024).
  12. Yamazaki K., Ishida K., Otsu W., Muramatsu A., Nakamura S., Yamada W., Tsusaki H., Shimoda H., Hara H., Shimazawa M.
    Delphinidins from Maqui berry (Aristotelia chilensis) ameliorate the subcellular organelle damages induced by blue light exposure in murine photoreceptor-derived cells
    BMC Complementary Medicine and Therapies, 24:3 (2024).
  13. Araki T., Shimazawa M., Nakamura S., Otsu W., Numata Y, Sakata M., Kabayama K., Tsusaki H., Hara H.
    Investigation into the usefulness of cynomolgus monkeys with spontaneously elevated intraocular pressure as a model for glaucoma treatment research
  14. Sasaki T., Kuse Y., Nakamura S., Shimazawa M.
    Progranulin-deficient macrophages cause cardiotoxicity under hypoxic conditions
    Biochemical and Biophysical Research Communications, 691, 149341 (2024).

2023年 (16報)

  1. Yamada K.,Tazaki A., Ushio-Watanabe N., Usui Y., Takeda A., Suzumura A., Zheng H., Ariefta N R., Hara H., Goto H., Sonoda K., Nishiguchi K., Kato M.,Nishikawa Y., Toyokuni S., Kaneko H.
    Retinal ferroptosis as novel pathogenesis and its diagnostic and therapeutic potential for ocular toxoplasmosis
    Redox Biology, 67, 102890 (2023).
  2. Sasaki T., Kuse Y., Nakamura S., Shimazawa M. and Hara H.
    Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction
    FASEB BioAdvances, 5, 10, 395-411 (2023).
    ※FASEB BioAdvances雑誌表紙に採択！
  3. Fujimori H.#, Ohba T.#, Nakamura S., Shimazawa Y., Takahashi D., IwawakiT., Kamon J., Shimazawa M., Hara H. (#Contributed equally)
    LATS inhibitor protects 6-OHDA induced neuronal cell death in vitro and in vivo
    BPB Reports, 6, 4, 144-149 (2023).
  4. Otsu W., Chinen N., Sugisawa E., Kitano H., Nakamura S., Umigai N., Tsusaki H., Shimazawa M.
    Protective effect of crocetin against cytoskeletal injury induced by acrolein from cigarette smoke extract in C2C12 myoblasts
    Journal of Functional Foods, 106, 105611 (2023).
  5. Otsu W., Hara H., Ogawa K.
    Protective effect of Vaccinium myrtillus L. extract against UVA-induced injury in ARPE-19 cells
    Food Science and Technology Research, in press
  6. Ogawa K., Karitani T., Otsu W., Nishiyama K., Kunitake H., Goto Y., Nomiyama S., Hara H., Yamasaki M.
    Blueberry stem extract suppresses blue light emitting diode light induced endoplasmic 2 reticulum stress on retinal photoreceptor cells
    BPB Reports, 6, 3, 87-97 (2023).
  7. Fujimori H., Ohba T., Nakamura S., Shimazawa M, Hara H.
    The involvement of progranulin for α-synuclein reduction through autolysosome formation
    Biological and Pharmaceutical Bulletin, 46, 8, 1032-1040 (2023).
  8. Fuma S., HidakaY., Nishinaka A., Yasuda H., Aoshima K., Nakamura S., Hara H., Shimazawa M.
    Timolol maleate, a β-blocker eye drop, improved edema in retinal vein occlusion model
    Molecular Vision., 29:188-196 (2023).
  9. Hirakida H., Okumura T., Fujita R., Kuse Y., Mizoguchi T., Inagaki S., Nakamura S., Shimazawa M., Hara H.
    VGF nerve growth factor inducible has the potential to protect pancreatic β-cells
    Journal of Endocrinology, 257(3):e220267 (2023)
  10. Tanaka M., Nakamura S., Sakaue T., Yamamoto T., Maekawa M., Nishinaka A., Yasuda H., Yunoki K., Sato Y., Sawa M., Yoshino K., Shimazawa M., Hatano M., Tokuhisa T., Higashiyama S., Hara H.
    BCL6B (B-Cell CLL/Lymphoma 6 Member B Protein) Contributes to Ocular Vascular Diseases via Notch Signal Silencing
    ※ ATVB雑誌表紙に採択！
  11. Hidaka Y., Kuriyama A., Nishinaka A., Takahashi K., Nakaya S., Kubota T., Nakamura S., Shimazawa M., Hara H.
    Intake of Lactobacillus pentosus TJ515 prevents the formation of retinal edema in retinal vein occlusion model mice
    BPB reports, 6, 47-54 (2023).
  12. Nishinaka A., Tanaka M., Ohara K., Sugaru E., Shishido Y., Sugiura A., Moriguchi Y., Toui A., Nakamura S., Shimada K., Watanabe S., Hara H., Shimazawa M.
    TRPV4 channels promote vascular permeability in retinal vascular disease
    Experimental Eye Research, 228, 109405 (2023).
  13. Aoshima K., Inagaki S., Nakamura S., Hara H., Shimazawa M.
    ALK5 inhibitor acts on trabecular meshwork cell and reduces intraocular pressure  
    Experimental Eye Research, Volume 227, 109382 (2023).
  14. Hidaka Y., Nakamura S., Nishinaka A., Takajo Y., Inamasu S., Yomoda S., Shimazawa M., Hara H.
    Arctigenin prevents retinal edema in a murine retinal vein occlusion model
    Biological and Pharmaceutical Bulletin, 46, 3, 473-481 (2023).
  15. Okada N., Nakamura S., Shimazawa M.
    3-Nitropropionic acid enhances ferroptotic cell death via NOX2-mediated ROS generation in STHdhQ111 striatal cells carrying mutant Huntingtin
    Biological and Pharmaceutical Bulletin, 46, 2, 177-186 (2023).
  16. Oka N.#, Van T. H. Doan.#, Matsubara H., Imai T., Yoshioka Y., Katsuki J., Fujii S., Nakamura S., Shimazawa M., Hara H., and Sakurai K. (#Contributed equally)
    Protective effects of alpha-mangostin encapsulated in cyclodextrin-nanoparticle on cerebral ischemia

2022年 (13報)

  1. Otsu W., Yako T., Sugisawa E., Nakamura S., Tsusaki H., Umigai N., Shimazawa M., Hara H.
    Crocetin protects against mitochondrial damage induced by UV-A irradiation in corneal epithelial cell line HCE-T cells
    Journal of Pharmacological Sciences, 150, 4, 279-288 (2022).
  2. Tsuji S., Nakamura S., Shoda K., Yamada T., Shimazawa M., Nakayama N., Iwama T., and Hara H.
    NMDA receptor signaling induces the chemoresistance of temozolomide via upregulation of MGMT expression in glioblastoma cells
    Journal of Neuro-Oncology, 160, 375-388 (2022)
  3. Hirakida H., Nakamura S., Inagaki S., Tsuji S., Hayashi M., Shimazawa M., Hara H.
    Anti-diabetic effects of astaxanthin-rich extract derived from Paracoccus carotinifaciens on pancreatic β cells
    Journal of Functional Foods, Volume 97, 105252 (2022)
  4. Nakamura S.#, Nishinaka A.#, Hidaka Y., Shimazawa M., Thomas L., Bakker A. R., Hara H. (#Contributed equally)
    Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model
    Investigative Ophthalmology & Visual Science, 63, 14 (2022)
  5. Mizoguchi T., Fujimori H., Ohba T., Shimazawa M., Nakamura S., Shinohara M., and Hara H.
    Glutamatergic dysfunction is associated with phenotypes of VGF-overexpressing mice
    Experimental Brain Research, (2022)
  6. Nishinaka A., Tanaka M., Aoshima K., Kuriyama A., Sasaki T., Otsu W., Yasuda H., Nakamura S., Shimazawa M., Hara H.
    The pathological association between the anterior eye segment and the retina in a murine model of neovascular glaucoma
    THE FASEB JOURNAL, 36(6):e22323 (2022)
  7. Shoda K., Tsuji S., Nakamura S., Egashira Y., Enomoto Y., Nakayama N., Shimazawa M., Iwama T., and Hara H.
    Canagliflozin inhibits glioblastoma growth and proliferation by activating AMPK.
    Cellular and Molecular Neurobiology (2022)
  8. Ohno Y., Yako T., Satoh K., Nagase H., Shitara A., Hara H. and Kashimata M.
    Retinal damage alters gene expression profile in lacrimal glands of mice.
    Journal of Pharmacological Sciences, 149, 1, 20-26 (2022).
  9. Yako T., Otsu W., Nakamura S., Shimazawa M. and Hara H.
    Lipid droplet accumulation promotes RPE dysfunction.
    International Journal of Molecular Sciences, 23 (3), 1790 (2022).
  10. Morozumi W., Aoshima K., Inagaki S., Iwata Y., Takagi Y., Nakamura S., Hara H. and Shimazawa M.
    Piezo1 activation induces fibronectin reduction and PGF2α secretion via arachidonic acid cascade.
    Experimental Eye Research, 215 (2022) 108917.
  11. Takahashi K., Nakamura S., Shimazawa M. and Hara H.
    Progranulin insufficiency affects lysosomal homeostasis in retinal pigment epithelium.
    In Vivo, 36 (2) 610-617, (2022).
  12. Matsubara H., Imai T., Tsuji S., Oka N., Egashira Y., Enomoto Y., Nakayama N., Nakamura S., Shimazawa M., Iwama T. and Hara H.
    Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice.
    Journal of Pharmacological Sciences, 148, 1, 65-72, (2022).
  13. Fujimori H., Ohba T., Mikami M., Nakamura S., Ito K., Takahashi T., Kojima H., Arunasiri Iddamalgoda, Shimazawa M. and Hara H.
    The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment.
    Journal of Pharmacological Sciences, 148, 1, 162-171, (2022).

2021年（24報）

  1. Kinoshita T., Tomita H., Okada H., Niwa A., Hyodo F., Kanayama T., Matsuo M., Imaizumi Y., Kuroda T., Hatano Y., Miyai M., Egashira Y., Enomoto Y., Nakayama N., Sugie S., Matsumoto K., Yamaguchi Y., Matsuo M., Hara H., Iwama T. and Hara A.
    Endothelial cell-specific reduction of heparan sulfate suppresses glioma growth in mice.
    Discover Oncology, 12:50 (2021).
  2. Takahashi K., Nakamura S., Shimazawa M. and Hara H.
    Retinal degeneration and microglial dynamics in mature progranulin-deficient mice.
    International Journal of Molecular Sciences, 22, 21 (2021).
  3. Yako T., Nakamura M., Otsu W., Nakamura S., Shimazawa M. and Hara H.
    Mitochondria dynamics in the aged mice eye and the role in the RPE phagocytosis.
    Experimental Eye Research, 213 (2021) 108800.
  4. Okada N., Yako T., Nakamura S., Shimazawa M. and Hara H.
    Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant Huntingtin.
    Journal of Pharmacological Sciences, 147, 4 (2021).
  5. Otsu W., Ishida K., Chinen N., Nakamura S., Shimazawa M., Tsusaki H. and Hara H.
    Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells.
    Scientific Reports, 17;11(1):18555 (2021).
  6. Yasuda H., Tanaka M., Nishinaka A., Nakamura S., Shimazawa M. and Hara H.
    Role of activating transcription factor 4 in murine choroidal neovascularization model.
  7. Ohba T., Fujimori H., Nakamura S., Hayashi Y., Kono H., Shimazawa M. and Hara H.
    Huperzia serrata and the constitute of huperzine A attenuate MK-801-induced cognitive dysfunction in mice via PKC-Erk pathway.

  8. Aoyama Y., Inagaki S., Aoshima K.,Iwata Y., Nakamura S., Hara H. and Shimazawa M.
    Involvement of endoplasmic reticulum stress in rotenone-induced Leber hereditary optic neuropathy model and the discovery of new therapeutic agents.
    Journal of Pharmacological Sciences, 147, 2 (2021).

  9. Takahashi K., Nakamura S., Otsu W., Shimazawa M. and Hara H.
    Progranulin deficiency in Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation.
    Journal of Neuroinflammation, 25;18(1):164 (2021).

  10. Matsubara H, Imai T, Tsuji S, Oka N, Ohba T, Yamada T, Egashira Y, Nakamura S, Shimazawa M, Iwama T and Hara H.
    Involvement of cerebral blood flow on neurological and behavioral functions after subarachnoid hemorrhage in mice.
    Journal of Stroke and Cerebrovascular Diseases, 30, 9 (2021).

  11. Morozumi W, Aoshima K, Inagaki S, Iwata Y, Nakamura S, Hara H and Shimazawa M
    Piezo 1 is involved in intraocular pressure regulation.
    Journal of Pharmacological Sciences., 147, 2 (2021).
  12. Ishida K, Yako T, Tanaka M, Otsu W, Nakamura S, Shimazawa M, Tsusaki H, and Hara H.
    Free-radical scavenger NSP-116 protects the corneal epithelium against UV-A and blue LED light exposure.
    Biological and Pharmaceutical Bulletin., 44, 7 (2021).
  13. Tsuji S, Nakamura S, Yamada T, Susana de Vega, Okada Y, Inoue S, Shimazawa M and Hara H.
    HYBID derived from tumor cells and tumor-associated macrophages contribute to glioblastoma growth
    Brain Research., 1764, 1 (2021)
  14. Yako T, Nakamura M, Nakamura S, Hara H and Shimazawa M
    Pharmacological inhibition of mitochondrial fission attenuates oxidative stress-induced damage of retinal pigmented epithelial cells
    Journal of Pharmacological Sciences., 146, 3, 149-159 (2021) .
  15. Takahashi N, Matsunaga N, Natsume T, Kitazawa C, Itani Y, Hama A, Hayashi I, Shimazawa M, Hara H and Takamatsu H
    A longitudinal comparison in cynomolgus macaques of the effect of brimonidine on optic nerve neuropathy using diffusion tensor imaging magnetic resonance imaging and spectral domain optic coherence tomography
    Heliyon, 7, 4, e06701 (2021).
  16. Yamamoto T, Nitta K, Nishinaka A, Tanaka M, Nakamura S, Shimazawa M and Hara H
    Oral administration of NSP-116, a free radical scavenger, suppresses the symptoms of retinal vein occlusion in the murine model
    Experimental Eye Research, 204, 108453 (2021).
  17. Tanaka M, Inoue Y, Imai T, Tanida N, Takahashi K and Hara H
    Guanabenz and Clonidine, α2-Adrenergic Receptor Agonists, Inhibit Choroidal Neovascularization
    Current Neurovascular Research, 18, 1, 85-92 (2021).
  18. Tanaka M, Inoue Y, Yoshino Y, Kuse Y, Tanida N, Takahashi K, Miyamoto Y and Hara Hindex
    Ropinirole prevents light-induced retinal photoreceptor damage in mice
    BPB Reports, 4, 1, 1-5 (2021).
  19. Miyagi S, Nishinaka A, Yamamoto T, Otsu W, Nakamura S, Shimazawa M, Kitaoka T and Hara H
    Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion
    Experimental Eye Research, 204, 108441 (2021).
  20. Sato S, Mizutani Y, Yoshino Y, Masuda M, Miyazaki M, Hara H and Inoue S
    Pro-inflammatory cytokines suppress HYBID (hyaluronan (HA) -binding protein involved in HA depolymerization/KIAA1199/CEMIP) -mediated HA metabolism in human skin fibroblasts
    Biochemical and Biophysical Research Communications, 539, 5, 77-82 (2021).
  21. Nishinaka A#, Nakamura S#, Tanaka M, Masuda T, Inoue Y, Yamamoto T, Imai T, Hidaka Y, Shimazawa M and Hara H
    #Contributed equally
    Excess adiponectin in eyes with progressive ocular vascular diseases
    THE FASEB JOURNAL, 35(2):e21313 (2021).
  22. Mikami M, Takuya O, Yoshino Y, Nakamura S, Ito K, Kojima H, Takahashi T, Iddamalgoda A, Inoue S, Shimazawa M and Hara H
    Acorus calamus extract and its component α-asarone attenuate murine hippocampal neuronal cell death induced by L-glutamate and tunicamycin
    Bioscience, Biotechnology, and Biochemistry, 85,3,493-501 (2021).
  23. Iwata Y, Inagaki S, Morozumi W, Nakamura S, Hara H and Shimazawa M
    Treatment with GDF15, a TGFβ superfamily protein, induces protective effect on retinal ganglion cells
    Experimental Eye Research, 202:108338 (2021).
  24. Imai T, Tsuji S, Matsubara H, Ohba T, Sugiyama T, Nakamura S, Hara H and Shimazawa M
    Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic stroke models
    Naunyn-Schmiedeberg's Archives of Pharmacology, 394(1):73-84 (2021).

2020年（30報）

  1. Chinen N, Otsu W, Ohuchi K, Ando S, Nakamura S, Kono H, Shimazawa M and Hara H
    Brazilian green propolis promotes the cytoprotective expression of heme oxygenase-1 against oxidative stress injury in murine myoblast cells
    Functional Foods in Health and Disease, 10, 12 (2020).
  2. Tanaka M, Nakamura S, Maekawa M, Higashiyama S and Hara H
    ANKFY1 is essential for retinal endothelial cell proliferation and migration via VEGFR2/Akt/eNOS pathway
    Biochemical and Biophysical Research Communications, 4, 533 (2020).
  3. Ando S#, Suzuki S#, Okubo S, Ohuchi K, Takahashi K, Nakamura S, Shimazawa M, Fuji K and Hara H
    #Contributed equally
    Discovery of a CNS penetrant small molecule SMN2 splicing modulator with improved tolerability for spinal muscular atrophy
    Scientific Reports, 10:17472 (2020).
  4. Tsuji S, Nakamura S, Maoka T, Yamada T, Imai T, Ohba T, Yako T, Hayashi M, Endo K, Saio M, Hara H and Shimazawa M
    Anti-tumour effects of astaxanthin and adonixanthin on glioblastoma
    Marine Drugs, 18(9): 474, (2020).
  5. Inagaki S, Shimazawa M, Otsu W, Araki T, Numata Y, Nakamura S, Tsusaki H and Hara H
    Creation of retinal vein occlusion model in cynomolgus monkeys and determination of its pathological features
    Current Neurovascular Research (2020).
  6. Ando S#, Osanai D#, Takahashi K, Nakamura S, Shimazawa M, and Hara H
    #Contributed equally
    Survival motor neuron protein regulates oxidative stress and inflammatory response in microglia of the spinal cord in spinal muscular atrophy
    Journal of Pharmacological Sciences, 144, 4, 204-211 (2020).
  7. Matsubara H, Imai T, Yamada T, Egashira Y, Nakamura S, Shimazawa M, Iwama T and Hara H
    Importance of CBF measurement to exclude concomitant cerebral infarction in the murine endovascular perforation SAH model
    Journal of Stroke and Cerebrovascular Diseases, 29, 11 (2020).
  8. Ando S, Otsu W, Osanai D, Kamiya S, Ishida K, Nakamura S, Shimazawa M and Hara H
    Survival motor neuron protein modulates lysosomal function through the expression of transcription factor EB in motoneurons
    BPB Reports, 3, 4, 130-137 (2020).
  9. Ando S, Tanaka M, Chinen N, Nakamura S, Shimazawa M and Hara H
    SMN Protein Contributes to Skeletal Muscle Cell Maturation Via Caspase-3 and Akt Activation
    In Vivo, 34, 6, 3247-3254 (2020).
    Supplemental movie 1_Control siRNA
    Supplemental movie 2_Smn siRNA
  10. Nakamura S, Saito Y, Gouda T, Imai T, Shimazawa M, Nishimura Y and Hara H
    Therapeutic effects of iron chelation in atorvastatin-induced intracranial hemorrhage of zebrafish larvae
    Journal of Stroke and Cerebrovascular Diseases, 29, 11, (2020).
  11. Imai T, Matsubara H, Nakamura S, Hara H and Shimazawa M
    The mitochondria-targeted peptide, bendavia, attenuated ischemia/reperfusion-induced stroke damage
    Neuroscience, 443, 110-119 (2020).
  12. Nakamura S, Maoka T, Tsuji S, Hayashi M, Shimazawa M and Hara H
    Central nervous system migration of astaxanthin and adonixanthin following their oral administration in cynomolgus monkeys
    Journal of Nutritional Science and Vitaminology, 66, 5, 488-494 (2020).
  13. Kimura S, Kamatari O.Y , Kato Z, Hara H, Maeda S, Kamishina H and Honda R
    Canine SOD1 harboring E40K or T18S mutations promotes protein aggregation through distinct mechanisms
    Peer J, 8:e9512 (2020).
  14. Ohba T, Nakamura S, Shimazawa M, Hayashi Y, Kono H, Hara H
    Protective effects of Huperzia serrata and its components against oxidative damage and cognitive dysfunction
    PharmaNutrition, 13 (2020) .
  15. Sasaki T, Shimazawa M, Kanamori H, Yamada Y, Nishinaka A, Kuse Y, Suzuki G, Masuda T, Nakamura S, Hosokawa M, Minatoguchi S and Hara H
    Effects of progranulin on the pathological conditions in experimental myocardial infarction model
    Scientific Reports, 10:11842 (2020)
  16. Nakamura S, Maoka T, Kuse Y, Muramatsu A,Yoshino Y, Shimazawa M and Hara H
    Distribution of carotenoids and protective effects of zeaxanthin on retina of Ayu sweetfish (Plecoglossus altivelis)
    Journal of Oleo Science, 69, 9, 1095-1105 (2020).
  17. Ooe E, Yako T, Kuse Y, Sogon T, Nakamura S, Shimazawa M, Hara H
    The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cells
    Journal of Nutritional Food, 17, 1, 18-33 (2020).
  18. Ishida K, Nakano Y, Ojino K, Shimazawa M, Otsuka T, Inagaki S, Kawase K, Hara H and Yamamoto T
    Evaluation of bleb characteristics after trabeculectomy and glaucoma implant surgery in rabbit
    Ophthalmic Research (2020).
  19. Inagaki S, Shimazawa M, Hamaguchi K, Otsu W, Araki T, Sasaki Y, Numata Y, Tsusaki H and Hara H
    Anti-vascular endothelial growth factor antibody limits vascular leakage and decreases subretinal fibrosis in a cynomolgus monkey choroidal neovascularization model
    Current Neurovascular research, 17(4):420-428 (2020).
  20. Saito Y, Okuyoshi H, Nakamura S, Otsu W, Yamaguchi A, Hitchcock PF, Nagashima M, Hara H and Shimazawa M
    Tauroursodeoxycholic acid promotes neuronal survival and proliferation of tissue resident stem and progenitor cells in retina of adult zebrafish
    BPB Reports, 3, 3, 92-96 (2020).
  21. Saito Y, Yamaguchi A, Nakamura S, Okuyoshi H, Shimazawa M and Hara H
    Contribution of platelet-derived growth factor signaling to retina regeneration in zebrafish
    Neuroscience Letters, 727 (2020).
  22. Otsu W, Ishida K, Nakamura S, Shimazawa M and Hara H
    Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells
    Biochemical and Biophysical Research Communications, 526, 2, 479-484 (2020).
  23. Saito Y, Yako T, Otsu W, Nakamura S, Inoue Y, Muramatsu A, Nakagami Y, Shimazawa M and Hara H
    A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner
    Free Radical Biology & Medicine, 20;152:235-247 (2020).
  24. Saito Y, Nakamura S, Chinen N, Shimazawa M, Hara H
    Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model
    Journal of Pharmacological Sciences, 143, 2, 117-121 (2020).
  25. Noda Y, Tanaka M, Nakamura S, Ito J, Kakita A, Hara H and Shimazawa M
    Identification of VGF nerve growth factor inducible-producing cells in human spinal cords and expression change in patients with amyotrophic lateral sclerosis
    International Journal of Medical Sciences, 4;17(4):480-489 (2020).
  26. Nishinaka A, Nitta K, Seki T, Hara H and Shimazawa M
    The changes in blood flow seen in the eye after foot acupuncture treatment in mice
    Evidence-Based Complementary and Alternative Medicine, vol. 2020, Article ID 6405471, 6 pages, 2020.
  27. Imai T, Sugiyama T, Iwata S, Nakamura S, Shimazawa M and Hara H
    Levetiracetam, an antiepileptic drug has neuroprotective effects on intracranial hemorrhage injury
    Neuroscience, 431, 25-33 (2020).
  28. Yamada T, Tsuji S, Yano H, Nakamura S, Miyai M, Egashira Y, Nakayama N, Shimazawa M, Iwama T and Hara H
    Riluzole enhances the anti-tumor effects of temozolomide via suppression of MGMT expression in glioblastoma
    The Journal of Neurosurgery, 134;701-710 (2020).
  29. Morozumi W, Inagaki S, Nakamura S, Hara H and Shimazawa M
    Piezo channel plays a part in retinal ganglion cell damage
    Experimental Eye Reseach, 191, (2020).
  30. Maoka T, Nakamura S and Hara H
    Carotenoids of land-locked and sea-run types of masu salmon Oncorhynchus masou ishikawae inhabit in the Nagara Riva Japan, from the perspective of chemical ecological study
    Biochemical Systematics and Ecology, 93 (2020).

2019年（19報）

  1. Tanaka M, Kuse Y, Nakamura S, Hara H and Shimazawa M
    Potential effects of progranulin and granulins against retinal photoreceptor cell degeneration
    Molecular Vision, 25:902-911, 2019.
  2. Madokoro Y, Yoshino Y, Kato D, Sato T, Mizuno M, Kanamori T, Shimazawa M, Hida H, Hara H, Yoshida M, Borlongan C, Ojika K, Matsukawa N
    Reduced cholinergic activity in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice
    International Journal of Molecular Sciences, 20(21), 5367, 2019.
  3. Imai T, Iwata S, Miyo D, Nakamura S, Shimazawa M, Hara H
    A novel free radical scavenger, NSP-116, ameliorated the brain injury in both ischemic and hemorrhagic stroke model
    Journal of Pharmacological sciences, 141,3,119-126.2019.
  4. Tsuji S, Ohno Y, Nakamura S, Yamada T, Noda Y, Saio M, Iwama T, Shimazawa M, Hara H
    Temozolomide has anti-tumor effects through the phosphorylation of cPLA2 on glioblastoma cells
    Brain Research,1723:146396.2019.
  5. Nitta K, Nishinaka A, Hida Y, Nakamura S, Shimazawa M and Hara H
    Both oral and ocular administration of crocetin prevent retinal edema in a murine retinal vein occlusion model
    Molecular Vision, 25, 859-868, 2019.
  6. Takahashi K, Masuda T, Harada M, Inoue T, Nakamura S, Naito K, Hara H and Shimazawa M
    Anti-VEGFR2 antibody-modified micelle for triggered drug delivery and effective therapy of choroidal neovascularization
    Current Neurovascular Research, 16(3), 258-265, 2019.
  7. Ando S, Funato M, Ohuchi K, Inagaki S, Sato A, Seki J, Kawase C, Saito T, Nishio H, Nakamura S, Shimazawa M, Kaneko H and Hara H
    The protective effects of levetiracetam on a human iPSCs-derived spinal muscular atrophy model
    Neurochemical Research, 44(7), 1773-1779, 2019
  8. Ohba T#, Domoto S#, Tanaka M, Nakamura S, Shimazawa M and Hara H
    #Contributed equally
    Myalgic encephalomyelitis/chronic fatigue syndrome induced by repeated forced swimming in mice
    Biological and Pharmaceutical Bulletin, 42(7), 1140-1145, 2019.
    Highlighted Paper selected by Editor-in-Chief
  9. Inagaki S, Funato M, Seki J, Kawase C, Ouchi K, Ando S, Nakamura S, Shimazawa M, Kaneko H and Hara H
    Identification of the stress which causes optineurin aggregation
    Neuroscience and Medicine, 10, 150-161, 2019.
  10. Nakamura S#, Noguchi T#, Inoue Y, Sakurai S, Nishinaka A, Hida Y, Masuda T, Nakagami Y, Horai N, Tsusaki H, Hara H and Shimazawa M
    #Contributed equally
    Nrf2 activator RS9 suppresses pathological ocular angiogenesis and hyperpermeability
    Investigative Ophthalmology and Visual Science, 60, 1943-1952.
  11. Imai T, Iwata S, Hirayama T, Nagasawa H, Nakamura S, Shimazawa M and Hara H
    Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage
    Scientific Reports, 9, 6228, 2019.
  12. Hyakkoku K, Umeda N, Shimada S, Imai T, Morioka Y, Sakaguchi G and Hara H
    Post-stroke pain caused by peripheral sensory hypersensitization after transient focal cerebral ischemia in rats
    Brain Research, 1715(15), 35-40, 2019.
  13. Ando S#, Sato A#, Funato M, Ohuchi K, Inagaki S, Nakamura S, Shimazawa M, Kaneko H and Hara H
    #Contributed equally
    The effects of rufinamide on in vitro spinal muscular atrophy model
    Pharmacology & Pharmacy, 10, 159-168, 2019.
  14. Ohuchi K, Funato M, Ando S, Inagaki S, Sato A, Kawase C, Seki J, Nakamura S, Shimazawa M, Kaneko H and Hara H
    Impairment of oligodendrocyte lineages in Spinal Muscular Atrophy Model Systems
    NeuroReport, 30, 350-357, 2019.
  15. Noda Y, Motoyama S, Nakamura S, Shimazawa M and Hara H
    Neuropeptide VGF-derived peptide LQEQ-19 has neuroprotective effects in an in vitro model of amyotrophic lateral sclerosis
    Neurochemical Research 44(4), 897-904, 2019.
  16. Ohuchi K, Funato M, Yoshino Y, Ando S, Inagaki S, Sato A, Kawase C, Seki J, Saito T, Nishio H, Nakamura S, Shimazawa M, Kaneko H and Hara H
    Notch Signaling Mediates Astrocyte Abnormality in Spinal Muscular Atrophy Model Systems
    Scientific Reports, 9, 3701, 2019.
  17. Matsuo M, Kuse Y, Takahashi K, Kuwahara K, Tanito M, Kaidzu S, Shimazawa M, Hara H and Ohira A
    Carteolol hydrochloride reduces visible light-induced retinal damage in vivo and BSO/glutamate-induced oxidative stress in vitro
    Jounal of Pharmacological Sciences, 139(2), 84-90, 2019.
  18. Mizoguchi T, Shimazawa M Ohuchi K, Kuse Y, Nakamura S and Hara H
    Impaired cerebellar development in mice overexpressing VGF
    Neurochemical Research, 44(2), 374-387, 2019.
  19. Yako T, Kuse Y, Nakamura S, Shimazawa M, Motomura T and Hara H
    The Protective Effect of Blue Light Cutting Particles Mixed Optical Material against Blue LED light-Induced Photoreceptor and Cornea Cell Death
    Journal of Science and Technology in Lighting, 42, 29-32, 2019.

2018年（25報）

  1. Kameyama T, Ohuchi K, Funato M, Ando S, Inagaki S, Sato A, Seki J, Kawase C, Tsuruma K, Nishino I, Nakamura S, Shimazawa M, Saito T, Takeda S, Kaneko H and Hara H
    Efficacy of Prednisolone in Generated Myotubes Derived from Fibroblasts of Duchenne Muscular Dystrophy Patients
    Frontiers in pharmacology, 9, 1-12, 2018.
  2. Tsuruma K, Saito Y, Okuyoshi H, Yamaguchi A, Shimazawa M, Goldman D and Hara H
    Granulin 1 Promotes Retinal Regeneration in Zebrafish
    Investigative Ophthalmology & Visual Science, 59, 6057-6066, 2018.
  3. Takeuchi H,Inagaki S, Morozumi W, Nakano Y, Inoue Y, Kuse Y, Mizoguchi T, Nakamura S, Funato M, Kaneko H, Hara H and Shimazawa M
    VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush
    Scientific Reports, 8, 16443, 2018.
  4. Yokota S, Kobatake Y, Noda Y, Nakata K, Yamato O, Hara H, Sakai H, Nishida H, Maeda S, Kamisina H
    Activation of the unfolded protein response in canine degenerative myelopathy
    Neuroscience Letters, 687, 216-222, 2018.
  5. Yoshino Y, Goto M, Hara H and Inoue S
    The role and regulation of TMEM2 (transmembrane protein 2) in HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/ KIAA1199/CEMIP)-mediated HA depolymerization in human skin fibroblasts
    Biochemical and Biophysical Research Communications, 505, 74-80, 2018.
  6. Saito Y, Kuse Y, Inoue Y, Nakamura S, Hara H and Shimazawa M
    Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival
    Redox Biology,19, 354-363, 2018.
  7. Sugiyama T, Imai T, Nakamura S, Yamauchi K, Sawada S, Shimazawa M and Hara H
    A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase
    Brain Research, 1701, 137-145, 2018.
  8. Saito Y, Gouda T, Nakamura S, Ichihara K, Hara H and Shimazawa M
    Water extract of Brazilian green propolis attenuates high glucose-induced vascular morphological abnormality in zebrafish
    Journal of Functional Foods, 49, 250-257, 2018.
  9. Nishinaka A, Inoue Y, Fuma S, Hida Y, Nakamura S, Shimazawa M and Hara H
    Pathophysiological role of VEGF on retinal edema and nonperfused areas in mouse eyes with retinal vein occlusion
    Investigative Ophthalmology & Visual Science, 59, 4701-4713, 2018.
  10. Iwata S, Imai T, Shimazawa M, Ishibashi T, Hayashi M, Hara H and Nakamura S
    Protective effects of the astaxanthin derivative, adonixanthin, on brain hemorrhagic injury
    Brain Research, 1698, 130-138, 2018.
  11. Ooe E, Kuse Y, Yako T, Sogon T, Nakamura S, Hara H and Shimazawa M
    Bilberry extract and anthocyanins suppress unfolded protein response induced by blue LED light exposure of cells in photoreceptor cell line
    Molecular Vision,24, 621-32, 2018.
  12. Yoshino Y, Shimazawa M, Nakamura S, Inoue S, Yoshida H, Shimoda M, Okada Y and Hara H
    Targeted deletion of HYBID (hyaluronan binding protein involved in hyaluronan depolymerization/ KIAA1199/CEMIP) decreases dendritic spine density in the dentate gyrus through hyaluronan accumulation
    Biochemical and Biophysical Research Communications,503(3),1934-1940,2018.
  13. Kuse Y, Takahashi K, Inoue Y, Izawa H, Nakamura S, Shimazawa M and Hara H
    Intravitreal aflibercept protects photoreceptors of mice against excessive light exposure
    Journal of Pharmacological Sciences, 137, 407-411, 2018.
  14. Nakamura M, Yako T, Kuse Y, Inoue Y, Nishinaka A, Nakamura S, Shimazawa M and Hara H
    Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice
    Experimental Eye Research, 177, 1-11, 2018.
  15. Kuse Y, Ohuchi K, Nakamura S, Hara H and Shimazawa M
    Microglia increases the proliferation of retinal precursor cells during postnatal development
    Molecular Vision, 24, 536-545, 2018.
  16. Ohuchi K, Ono Y, Joho M, Tsuruma K, Ogami S, Yamane S, Funato M, Kaneko H, Nakamura S, Hara H and Shimazawa M
    A docosahexaenoic acid-derived pro-resolving agent, maresin 1, protects motor neuron cells death.
    Neurochemical Research, 43(7), 1413-1423, 2018.
  17. Moriguchi M, Nakamura S, Inoue Y, Nishinaka A, Nakamura M, Shimazawa M and Hara H
    Irreversible photoreceptors and RPE cells damage by intravenous sodium iodate in mice is related to macrophage accumulation
    Investigative Ophthalmology & Visual Science, 59, 3476-3487, 2018.
  18. Horibe M, Sasaoka S, Naganuma M, Hasegawa S, Hara H and Nakamura M
    Analysis of mother's sentiments regarding postpartum depression by text mining: Based on contents of remarks on social media.
    Japanese Journal of Nursing and Health Sciences, 16, 53-63, 2018.
  19. Hida Y, Nakamura S, Nishinaka A, Inoue Y, Shimazawa M and Hara H
    Effects of ripasudil, a ROCK inhibitor, on retinal edema and nonperfusion area in a retinal vein occlusion murine model.
    Journal of Pharmacological Sciences, 137(2), 129-136, 2018.
  20. Arimura S, Takamura Y, Miyake S, Kojima A, Sakurai S, Turuma K, Hara H and Inatani M
    Inhibitory Effect of Alpha-Crystallins on VEGF-Induced Proliferation of Retinal Microvascular Endothelial Cells
    J Clin Exp Ophthalmol 2018, 9:1
  21. Horibe M, Hane Y, Abe J, Matsui T, Kato Y, Ueda N, Sasaoka S, Motooka Y, Hatahira H, Hasegawa S, Kinosada Y, Hara H, Nakamura M.
    Contraceptives as possible risk factors for postpartum depression: a retrospective study of the Food and Drug Administration Adverse Event Reporting System, 2004-2015
    Nursing Open, 5, 131-138, 2018.
  22. Mizoguchi T.#, Minakuchi H.#, Tanaka M., Tsuruma K., Shimazawa M. and Hara H.
    #Contributed equally
    Sensorimotor gating deficits and effects of antipsychotics on the hyperactivity in VGF-overexpressing mice.
    Pharmacological Reports, 70, 476-480, 2018.
  23. Inoue Y., Shimazawa M., Nakamura S., Takata S., Hashimoto Y., Izawa H., Masuda T., Tsuruma K., Sakaue T., Nakayama H., Higashiyama S. and Hara H.
    Both autocrine and paracrine signaling of heparin-binding epidermal growth factor-like growth factor enhances ocular neovascularization
    Arteriosclerosis, Thrombosis, and Vascular Biology, 38, 174-185, 2018.
  24. Domoto S., Ohba T., Yoshino Y., Horibe M., Yako T., Shimazawa M. and Hara H.
    Exposure to blue LED light at subjective daytime does not affect brain function in pigmented mice.
    Journal of Science and Technology in Lighting, 41, 22-29, 2017.
  25. Imamura T., Tsuruma K., Inoue Y., Otsuka T., Ohno Y., Ogami S., Yamane S., Shimazawa M. and Hara H.
    Involvement of cannabinoid receptor type 2 in light-induced degeneration of cells from mouse retinal cell line in vitro and mouse photoreceptors in vivo
    Experimental Eye Research, 167, 44-50, 2018.

2017年（37報）

  1. Takahashi K., Shimazawa M., Izawa H., Inoue Y., Kuse Y. and Hara H.
    Platelet-derived growth factor-BB lessens light-induced rod photoreceptor damage in mice
    Investigative Ophthalmology & Visual Science, 58, 14, 6299-6307, 2017.
  2. Ohno Y., Otsuka Y., Nohara M., Furihata T., Kuse Y., Itoh Y., Hara H. and Anzai N.
    Characterization of an L-carnitine transport system in murine photoreceptor cell line.
    Biol. Pharm. Bull., 40, 2110-2116, 2017.
  3. Yamauchi K., Imai T., Shimazawa M., Iwama T. and Hara H.
    Effects of ticagrelor in a mouse model of ischemic stroke.
    Scientific Reports, 7, 12088, 2017.
  4. Noda Y.#, Tsuruma K.#, Takata M.#, Ishisaka M., Tanaka H., Nakano Y., Nagahara Y., Shimazawa M. and Hara H.
    #Contributed equally
    GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response.
    Scientific Reports, 7, 12160, 2017.
  5. Ando S., Funato M., Ohuchi K., Kameyama T., Inagaki S., Seki J., Kawase C., Tsuruma K., Shimazawa M., Kaneko H. and Hara H.
    Edaravone is a candidate agent for spinal muscular atrophy: in vitro analysis using a human induced pluripotent stem cells-derived disease model.
    European Journal of Pharmacology, 814, 161-168, 2017.
  6. Horibe M.#, Yoshino Y.#, Domoto S., Nakamura M., Shimazawa M. and Hara H.
    The effects of blue LED light on behavior and retinal function in maternal and offspring mice.
    Journal of Behavioral and Brain Science, 7, 348-359, 2017.
  7. Kuroda A., Enomoto N., Ishida K., Shimazawa M., Noguchi T., Horai N., Onoe H., Hara H. and Tomita G.
    Movement of retinal vessels toward the optic nerve head after increasing intraocular pressure in monkey eyes with experimental glaucoma.
    Experimental Eye Research, 162, 110-115, 2017.
  8. Tokunaga E., Akiyama H., Soloshonok V., Inoue Y., Hara H. and Shibata N.
    Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others
    PLOS ONE, 12(8):e0182152, 2017.
  9. Momose K., Takenaka T., Nakamura M. and Hara H.
    Drug discovery support processes from Japanese academia -An innovative drug development support measure from 1990 through 2017-
    The Japanese Journal of History of Pharmacy, 52, 1, 51-63, 2017.
  10. Sakata C., Kawasaki T., Iwatsuki Y., Moritani Y., Morita Y. and Hara H.
    Inhibitory effects of ASP6537, a selective cyclooxygenase-1 inhibitor, on thrombosis and neointima formation in rats
    Thrombosis Research, 157, 72-78, 2017.
  11. Tanaka M.#, Yoshino Y.#, Takeda S., Toda K., Shimoda H., Tsuruma K., Shimazawa M. and Hara H.
    Fermented rice germ extract alleviates morphological and functional damage to murine gastrocnemius muscle via inactivation of AMP-activated protein kinase
    Journal of Medicinal Food, 20(10), 969-980, 2017.
  12. Imai S., Otsuka T., Naito A., Shimazawa M. and Hara H.
    Triamcinolone Acetonide Suppresses Inflammation and Facilitates Vascular Barrier Function in Human Retinal Microvascular Endothelial Cells.
    Current Neurovascular Research, 14(3), 232-241, 2017.
  13. Kuse Y., Nakamura M., Yako T., Kunihiro C., Shimazawa M. and Hara H.
    Comparison of Retinal Damage Induced by Electrodeless Lamp and White LED in Mice.
    Atarashii Ganka (Journal of the Eye) 34(5), 749-753, 2017.
  14. Nishinaka A., Fuma S., Inoue Y., Shimazawa M. and Hara H.
    Effects of kallidinogenase on retinal edema and size of non-perfused areas in mice with retinal vein occlusion
    Journal of Pharmacological Sciences, 134, 2, 86-92, 2017.
  15. Inoue Y., Shimazawa M, Nagano R., Kuse Y., Takahashi K., Tsuruma K., Hayashi M., Ishibashi T., Maoka T. and Hara H.
    Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration.
    Journal of Pharmacological Sciences, 134, 147-157, 2017.
  16. Kustiawan P.M.#, Okuyoshi H.#, Kuse Y., Izawa H., Saito Y., Tsuruma K., Chanchao C., Hara H. and Shimazawa M.
    #Contributed equally
    Protective Effects of Indonesian Propolis Against Light-Induced Retinal Damage.
    International Journal of Toxicological and Pharmacological Research, 92, 163-170, 2017.
  17. Mizoguchi T., Minakuchi H., Ishisaka M., Tsuruma K., Shimazawa M. and Hara H.
    Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF.
    Scientific Reports, 7, 4691, 2017.
  18. Murase H., Tsuruma K., Kuse Y., Shimazawa M. and Hara H.
    Progranulin Increases Phagocytosis by Retinal Pigment Epithelial Cells in Culture
    Journal of Neuroscience Research, 95(12), 2500-2510, 2017.
  19. Nakamura M., Kuse Y., Tsuruma K., Shimazawa M. and Hara H.
    The involvement of the oxidative stress in murine blue LED light-induced retinal damage model
    Biol. Pharm. Bull., 40, 8, 1219-1225, 2017.
  20. Nishida T., Kuse Y., Mochizuki K., Shimazawa M., Yamamoto T. and Hara H.
    Protective effects of fluoroquinolones on UV-induced damage of cultured ocular cell lines
    European Journal of Pharmacology, 806, 59-66, 2017.
  21. Kuse Y., Tsuruma K., Mizoguchi T., Shimazawa M. and Hara H.
    Progranulin deficiency causes the retinal ganglion cell loss during development.
    Scientific Reports, 7, 1679, 2017.
  22. Kuse Y., Tsuruma K., Kanno Y., Shimazawa M. and Hara H.
    CCR3 is associated with death of cells of photoreceptor cell-line induced by light exposure.
    Frontiers in Pharmacology, 8(5223), 2017.
  23. Noguchi T., Shimazawa M., Hamaguchi K., Araki T., Horai N. and Hara H.
    Relationship between elevated intraocular pressure and divided peripapillary sector retinal nerve fiber layer thickness in a cynomolgus monkey laser-induced ocular hypertension model
    Ophthalmic Research, 58, 2, 99-106, 2017.
  24. Inoue Y., Shimazawa M., Noda Y., Nagano R., Otsuka T., Kuse Y., Nakano Y., Tsuruma K., Nakagami Y. and Hara H.
    RS9, a novel Nrf2 activator, attenuates light-induced death of cells of photoreceptor cells and Müller glia cells.
    Journal of Neurochemistry, 141, 5, 750-765, 2017.
  25. Imamura T., Tsuruma K., Inoue Y., Otsuka T., Ohno Y., Ogami S., Yamane S., Shimazawa M. and Hara H.
    Rimonabant, a selective cannabinoid1 receptor antagonist, protects against light-induced retinal degeneration in vitro and in vivo
    European Journal of Pharmacology, 803, 78-83, 2017.
  26. Imai T.#, Matsukawa H.#, Takagi T., Tsuruma K., Shimazawa M. and Hara H.
    #Contributed equally
    The phosphodiesterase III inhibitor cilostazol protects the brain microvasculature from collagenase injury
    NeuroReport, 28(10), 555-560, 2017.
  27. Nakano Y., Shimazawa M., Ojino K., Izawa H., Takeuchi H., Inoue Y., Tsuruma K. and Hara H.
    Toll-like receptor 4 inhibitor protects against retinal ganglion cell damage induced by optic nerve crush in mice
    Journal of Pharmacological Sciences, 133(3): 176-183, 2017.
  28. Ooe E., Tsuruma K., Kuse Y., Kobayashi S., Shimazawa M. and Hara H.
    The involvement of ATF4 and S-opsin in retinal photoreceptor cell damage induced by blue LED light.
    Molecular Vision, 23, 52-59, 2017.
  29. Yoshino Y., Ishisaka M., Tsuruma K., Shimazawa M., Yoshida H., Inoue S., Shimoda M., Okada Y. and Hara H.
    Distribution and function of hyaluronan binding protein involved in hyaluronan depolymerization (HYBID, KIAA1199) in the mouse central nervous system
    Neuroscience, 347, 1-10, 2017.
  30. Fuma S., Nishinaka A., Inoue Y., Tsuruma K., Shimazawa M., Kondo M. and Hara H.
    A pharmacological approach in newly established retinal vein occlusion model
    Scientific Reports, 7, 43509, 2017.
  31. Masuda T., Shimazawa M., Hashimoto Y., Kojima A., Nakamura S., Suemori S., Mochizuki K., Kawakami H., Kawase K., and Hara H.
    Apolipoprotein E2 and E3, but not E4, promote retinal pathological neovascularization
    Investigative Ophthalmology & Visual Science, 58, 1208-1217, 2017.
  32. Shimoda M., Yoshida H., Mizuno S., Hirozane H., Horiuchi K., Yoshino Y., Hara H., Kanai Y., Inoue S., Ishijima M. and Okada Y.
    HYBID (hyaluronan binding protein involved in hyaluronan depolymerization, KIAA1199) controls endochondral ossification through hyaluronan metabolism
    The American Journal of Pathology, 187(5): 1162-1176, 2017.
  33. Wan-Ju Chen, Caiying Wu, Zhenhua Xu, Kuse Y., Hara H. and Elia Duh.
    Nrf2 protects photoreceptor cells from photo-oxidative stress induced by blue light.
    Exp. Eye Res., 154, 151-158, 2017.
  34. Nagahara Y., Shimazawa M., Ohuchi K., Ito J., Takahashi H., Tsuruma K., Kakita A. and Hara H.
    GPNMB Ameliorates Mutant TDP-43-Induced Motor Neuron Cell Death.
    Journal of Neuroscience Research, 95(8): 1647-1665, 2017.
  35. Imai T., Mishiro K., Takagi T., Isono A., Nagasawa H., Tsuruma K., Shimazawa M. and Hara H.
    Protective effect of bendavia (SS-31) against oxygen/glucose-deprivation stress-induced mitochondrial damage in human brain microvascular endothelial cells
    Current Neurovascular Research, 14(1): 53-59, 2017.
  36. Shimazawa M., Inoue Y., Masuda T., Onodera R., Tahara K., Shimizu Y., Mibe Y., Tsuruma K., Takeuchi H. and Hara H.
    Topical diclofenac-loaded liposomes ameliorate laser-induced choroidal neovascularization in mice and non-human primates
    Current Neurovascular Research, 14(1): 46-52, 2017.
  37. Takagi T, Imai T, Mishiro K, Ishisaka M, Tsujimoto M, Ito H, Nagashima K, Matsukawa H, Tsuruma K, Shimazawa M, Yoshimura S, Kozawa O, Iwama T and Hara H.
    Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood-brain barrier.
    Journal of Cerebral Blood Flow and Metabolism, 37(1), 123-139 2017.

2016年 (19報)

  1. Sawada S., Ono Y., Egashira Y., Takagi T., Tsuruma K., Shimazawa M., Iwama T. and Hara H.
    In models of intracerebral hemorrhage, rivaroxaban is superior to warfarin to limit blood brain barrier disruption and hematoma expansion.
    Current Neurovascular Research, Volume 13 (E-pub ahead of print), 2016.
  2. Ono Y., Chiba S., Yano H., Nakayama N., Saio M., Tsuruma K., Shimazawa M., Iwama T. and Hara H.
    Glycoprotein nonmetastatic melanoma protein B (GPNMB) promotes the progression of brain glioblastoma via Na+/K+-ATPase.
    Biochemical and Biophysical Research Communications, 481, 7-12, 2016.
  3. Kakefuda K., Ishisaka M., Tsuruma K., Shimazawa M. and Hara H.
    Memantine, an NMDA receptor antagonist, improves working memory deficits in DGK (beta) knockout mice
    Neuroscience Letters,630, 228-232, 2016.
  4. Yamauchi K., Nakano Y., Imai T., Takagi T., Tsuruma K., Shimazawa M., Iwama T. and Hara H.
    A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice
    Neuroscience, 333, 302-310, 2016.
  5. Ohba T., Ishisaka M., Tsujii S., Tsuruma K., Shimazawa M., Kubo K., Umigai N., Iwawaki T. and Hara H.
    Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo
    European Journal of Pharmacology, 789, 244-253, 2016.
  6. Saito Y., Tsuruma K., Shimazawa M., Nishimura Y., Tanaka T. and Hara H.
    Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish
    J Pharmacol. Sci., 131(3), 215-218, 2016.
  7. Kawase R., Nishimura Y., Ashikawa Y., Sasagawa S., Murakami S., Yuge M., Okabe S., Kawaguchi K., Yamamoto H., Moriyuki K., Yamane S., Tsuruma K., Shimazawa M., Hara H. and Tanaka T.
    EP300 Protects from Light-induced Retinopathy in Zebrafish
    Frontiers in Pharmacology, 7:126, 2016.
  8. Ohuchi K., Tsuruma K., Shimazawa M., Nakamura J. and Hara H.
    The novel cPLA2 inhibitor AK106-001616 has a protective effect on SOD1G93A -induced cell death in NSC34 murine motor neuron-like cells.
    Pharmacology & Pharmacy, 7(5), 193-199, 2016.
  9. Izawa H., Shimazawa M., Inoue Y., Uchida S., Moroe H., Tsuruma K. and Hara H.
    Protective effects of NSP-116, a novel imidazolyl aniline derivative, against light-induced retinal damage in vitro and in vivo
    Free Radic. Biol. Med., 96, 304-312, 2016.
  10. Masuda T., Shimazawa M., Takata S., Nakamura S., Tsuruma K. and Hara H.
    Edaravone is a free radical scavenger that protects against laser-induced choroidal neovascularization in mice and common marmosets.
    Exp. Eye Res., 146, 196-205, 2016
  11. Kuse Y., Tsuruma K., Sugitani S., Izawa H., Ohno Y., Shimazawa M. and Hara H.
    Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina.
    Scientific Reports, 6, 23811, 2016.
  12. Hiromoto K., Kuse Y., Tsuruma K., Tadokoro N., Kaneko N., Shimazawa M. and Hara H.
    Colored lenses suppress blue light-emitting diode light-induced damage in photoreceptor-derived cells.
    J. Biomed. Opt., 21(3), 035004, 2016.
  13. Ono Y., Tsuruma K., Takata M., Shimazawa M. and Hara H.
    Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.
    Scientific Reports, 6, 23241, 2016.
  14. Imai T., Takagi T., Kitashoji A., Yamauchi K., Shimazawa M. and Hara H.
    Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation.
    Neurobiology of Disease, 89, 136-146, 2016.
  15. Mizoguchi T., Ishisaka M., Kobatake Y., Kamishina H., Nishioka Y., Kirimoto T., Shimazawa M. and Hara H.
    Establishment and effects of ginger and kikyoto of a haloperidol-induced dysphagia model in guinea pigs.
    Pharmacology & Pharmacy, 7(2), 97-105, 2016.
  16. Otsuka T., Shimazawa M., Inoue Y., Nakano Y., Ojino K., Izawa H., Tsuruma K., Ishibashi T. and Hara H.
    Astaxanthin protects against retinal damage: Evidence from in vivo and in vitro retinal ischemia and reperfusion models.
    Current Eye Research, Volume 41, Issue 11. 1465-1472, 2016.
  17. Fuma S., Shimazawa M., Imamura T., Kanno Y., Takano N., Tsuruma K. and Hara H.
    Neuroprotective effect of ocular hypotensive drugs: Latanoprost/timolol in combination are more effective than each as monotherapy in RGC-5.
    Biol. Pharm. Bull., 39(2), 192-198, 2016. Highlighted Paper selected by Editor-in-Chief (The selection is based upon originally, scientific contributions, methodological pertinence, and composition.)
  18. Ohuchi K., Funato M., Kato Z., Seki J., Kawase C., Tamai Y., Ono Y., Nagahara Y., Noda Y., Kameyama T., Ando S., Tsuruma K., Shimazawa M., Hara H. and Kaneko H.
    Established stem cell model of spinal muscular atrophy is applicable in the evaluation of the efficacy of thyrotropin-releasing hormone analog.
    STEM CELLS Translational Medicine, 5, 152-163, 2016.
  19. Ooe E., Ogawa K., Horiuchi T., Tada H., Murase H., Tsuruma K., Shimazawa M. and Hara H.
    Analysis and characterization of anthocyanins and carotenoids in japanese blue tomato.
    Bioscience, Biotechnology, and Biochemistry, 80(2), 341-349, 2016.

2015年（22報）

  1. Saito Y., Tsuruma K., Ichihara K., Shimazawa M. and Hara H.
    Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation.
    BMC Complementary and Alternative Medicine, 15:421, 2015.
  2. Izawa H., Inoue Y., Ohno Y., Ojino K., Tsuruma K., Shimazawa M. and Hara H.
    Protective effects of anti-placental growth factor antibody against light-induced retinal damage in mice. Invest. Ophthalmol. Vis. Sci., 56, 6914-6924, 2015.
  3. Ojino K., Shimazawa M., Izawa H., Nakano Y., Tsuruma K. and Hara H.
    The involvement of endoplasmic reticulum stress in optic nerve degeneration after chronic high intraocular pressure in DBA/2J mice.
    J. Neurosci. Res., 93, 1675-1683, 2015.
  4. Fuma S., Murase H., Kuse Y., Tsuruma K., Shimazawa M. and Hara H.
    Photobiomodulation of 670 nm light increased the phagocytosis in the human retinal pigment epithelial cells.
    Molecular Vision, 21, 883-892, 2015.
  5. Nagahara Y., Shimazawa M., Tanaka H., Ono Y., Noda Y., Ohuchi K., Tsuruma K., Katsuno M., Sobue G. and Hara H.
    GPNMB ameliorates skeletal muscle lesions in a SOD1G93A mouse model of amyotrophic lateral sclerosis.
    J. Neurosci. Res., 93, 1552-1566, 2015.
  6. Tsuruma K., Takano N., Imai S., Saito Y., Ito T. and Hara H.
    Investigation of preventive effects of propolis and its constituents against age-related macular degeneration.
    Food Function, 14, 25-31, 2015.
  7. Ohba T., Yoshino Y., Ishisaka M., Abe N., Tsuruma K., Shimazawa M., Oyama M., Tabira T. and Hara H. Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice.
    Bioscience, Biotechnology, and Biochemistry, 79, 1838-1844, 2015.
  8. Kanematsu M., Futamura M., Takata M., Gaowa S., Yamada A., Morimitsu K., Morikawa A., Mori R., Hara H. and Yoshida K.
    Clinical significance of glycoprotein non-metastatic B and its association with HER2 in breast cancer. Cancer Medicine, 4,1344-1355, 2015.
  9. Takata S.#, Masuda T.# , Nakamura S., Kuchimaru T., Tsuruma K., Shimazawa M., Nagasawa H., Kondoh S. and Hara H. #
    Contributted equally, The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe.
    Scientific Reports, 5: 9898, 2015.
  10. Murase H., Tsuruma K., Shimazawa M. and Hara H.
    TUDCA promotes phagocytosis by retinal pigment epithelium via MerTK activation.
    Invest. Ophthalmol. Vis. Sci., 56, 2511-2518, 2015.
  11. Noda Y., Shimazawa M., Tanaka H., Tamura S., Inoue T., Tsuruma K. and Hara H.
    VGF and striatal cell damage in in vitro and in vivo models of Huntington's disease.
    Pharmacology Research & Perspectives, 3, e00140, 2015.
  12. Suzuki Y., Suzuki H., Umetsu R., Uranishi H., Abe J., Nishibata Y., Sekiya Y., Miyamura N., Hara H., Tsuchiya T., Kinosada Y. and Nakamura M.
    The analysis of the interaction between clopidogrel, aspirin and proton pump inhibitors using the FDA Adverse Event Reporting System database.
    Biological and Pharmaceutical Bulletin, 38, 680-686, 2015.
  13. Shimazawa M., Masuda T., Nakamura S., Miwa M., Nakamura K. and Hara H.
    An experimental model for exudative age-related macular degeneration with choroidal neovascularization using the common marmoset.
    Current Neurovascular Research, 12, 128-134, 2015.
  14. 柿野衛、田澤茂実、丸山広恵、荒木陽子、市原賢二、河野宏行、飯沼宗和、原英彰
    ジンチョウゲ科ジンコウ属（Aquilaria属）植物の葉部エキス含有食品の二重盲検クロスオーバーによる有効性試験ならびに安全性試験 A double-blinded, placebo-controlled, crossover trial and open-label safety trials of extract of Aquilaria sp (Thymelaeaceae) leaves.
    Jpn. Pharmacol. Ther.（薬理と治療）, 43, 209-229, 2015.
  15. Yoshino Y., Ishisaka M., Tsujii S., Shimazawa M. and Hara H.
    Glucagon-like peptide-1 protects the murine hippocampus against stressors via Akt and ERK1/2 signaling. Biochemical and Biophysical Research Communications, 458, 274-279, 2015.
  16. Shimazawa M., Sugitani S., Inoue Y., Tsuruma K. and Hara H.
    Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage.
    Experimental Eye Research, 132, 64-72, 2015.
  17. Abe J., Mataki K., Umetsu R., Ueda N., Kaato Y., Nakayama Y., Kinosada Y., Hara H., Inagaki N. and Nakamura M.
    Stevens-Johnson syndrome and toxic epidermal necrolysis: The Food and Drug Administration adverse event reporting system, 2004-2013.
    Allergol Int., 64(3), 277-279. 2015.
  18. Murata K., Yoshino Y., Tsuruma K., Moriguchi S., Oyagi A., Tanaka H., Ishisaka M., Shimazawa M., Fukunaga K., Hara H.
    The extracellular fragment of GPNMB improves memory and increases hippocampal GluA1 levels in mice. Journal of Neurochemistry, 132, 583-594, 2015.
  19. Hozumi Y., Kakefuda K., Yamasaki M., Watanabe M., Hara H. and Goto K.
    Involvement of diacylglycerol kinase β in the spine formation at distal dendrites of striatal medium spiny neurons. Brain Research, 1594, 36-45, 2015.
  20. Ishisaka M., Tsujii S., Mizoguchi T., Tsuruma K., Shimazawa M. and Hara H.
    The effects of valproate and olanzapine on the abnormal behavior of diacylglycerol kinase β knockout mice.
    Pharmacological Reports, 67, 2, 275-280, 2015.
  21. Tsujii S., Ishisaka M., Shimazawa M., Hashizume T. and Hara H.
    Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivo. European Journal of Pharmacology, 741, 301-307, 2015.
  22. Kaneko M., Noguchi T., Ikegami S., Sakurai T., Kakita A., Toyoshima Y., Kambe T., Yamada M., Inden M., Hara H., Oyanagi K., Inuzuka T., Takahashi H. and Hozumi I.
    Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis.
    J. Neurosci. Res., 93, 2, 370-379, 2015.

2014年（20報）

  1. Imamura T., Hirayama T., Tsuruma K., Shimazawa M., Nagasawa H. and Hara H. Hydroxyl radicals cause fluctuation in intracellular ferrous ion levels upon light exposure during photoreceptor cell death. Experimental Eye Research, 129, 24-30, 2014.
  2. Nakamura S., Shimazawa M., Inoue Y., Takata S., Ito Y., Tsuruma K., Ikeda T., Honda A., Satoh M. and Hara H. Role of metallothioneins 1 and 2 in ocular neovascularization. Invest. Ophthalmol. Vis. Sci., 55, 6851-6860, 2014.
  3. Takagi T., Mishiro K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. The phosphodiesterase III inhibitor cilostazol ameliorates ethanol-induced endothelial dysfunction. Current Neurovascular Research, 11, 302-311, 2014.
  4. Lin W., Lu Y., Xu Y., He W., Kawase K., Yamamoto T., Shimazawa M. and Hara H. Effect of anti-glaucoma ophthalmic solutions on cultured human conjunctival cells. Chin. J. Pract Ophthalmol, 32, 512-516, 2014.
  5. Mishiro K., Takahiko Imai T., Sugitani S., Kitashoji A., Suzuki Y., Takagi T., Chen H., Oumi Y., Tsuruma K., Shimazawa M. and Hara H. Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis. PLoS ONE, 9(8), e103818, 2014.
  6. Nakano Y., Suzuki Y., Takagi T., Kitashoji A., Ono Y., Tsuruma K., Yoshimura S., Shimazawa M., Iwama T. and Hara H. Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia reperfusion injury. Neuroscience, 277, 123-131, 2014.
  7. Akizawa T., Tsuruta Y., Okada Y., Miyauchi Y., Suda A., Kasahara H., Sasaki N., Maeda Y., Suzuki T., Matsui N., Niwayama J., Suzuki T., Hara H., Asano Y., Komemushi S. and Fukagawa M. Effect of chitosan chewing gum on reducing serum phosphorus in hemodialysis patients: a multi-center, randomized, double-blind, placebo-controlled trial. BMC Nephrology, 15:98, 2014.
  8. Omi T., Tanimukai H., Kanayama D., Sakagami Y., Tagami S., Okochi M., Morihara T., Sato M., Yanagida K., Kitashoji A., Hara H., Imaizumi K., Maurice T., Chevallier N., Marchal S., Takeda M. and Kudo T. Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor. Cell Death & Disease, 5, e1332, 2014.
  9. Kuse Y., Ogawa K., Tsuruma K., Shimazawa M., Hara H. Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light. Scientific Reports, 4: 5223, 2014.
  10. Masuda T., Shimazawa M., Ishizuka F., Nakamura S., Tsuruma K. and Hara H. Tissue kallikrein (kallidinogenase) protects against retinal ischemic damage in mice. European Journal of Pharmacology, 738, 74-82, 2014.
  11. Takagi T., Kitashoji A., Iwawaki T., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury. Free Radical Biology & Medicine, 72, 124-133, 2014.
  12. Ogawa K., Kuse Y., Tsuruma K., Kobayashi S., Shimazawa M. and Hara H. Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro. BMC Complementary and Alternative Medicine, 14:120, 2014.
  13. Umetsu R., Nishibata Y., Abe J., Suzuki Y., Hara H., Nagasawa H., Kinosada Y. and Nakamura M. Evaluation of the association between the use of oral anti-hyperglycemic agents and hypoglycemia in Japan by data mining of the Japanese adverse drug event report (JADER) database. Yakugaku Zasshi, 134, 299-304, 2014.
  14. Masuda T., Miyakubo H., Iinuma M. and Hara H. The antimicrobial effect of the extract of Canavalia gladiata on periodontal pathogen. Food Function, 13, 2-6, 2014.
  15. Ojino K., Shimazawa M., Ohno Y., Otsuka T., Tsuruma K. and Hara H. Protective effect of SUN N8075, a free radical scavenger, against excessive light-induced retinal damage in mice. Biological and Pharmaceutical Bulletin, 37, 424-430, 2014.
  16. Yoshino Y., Ishisaka M., Umigai N., Shimazawa M., Tsuruma K. and Hara H. Crocetin prevents amyloid β1-42-induced cell death in murine hippocampal cells. Pharmacology & Pharmacy, 5, 37-42, 2014.
  17. Inoue Y., Shimazawa M., Nakamura S., Imamura T., Sugitani S., Tsuruma K. and Hara H. Protective effects of placental growth factor on retinal neuronal cell damage. Journal of Neuroscience Research, 92, 329-337, 2014.
  18. Tsuruma K., Yamauchi M., Sugitani S., Otsuka T., Ohno Y., Nagahara Y., Ikegame Y., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Progranulin, a major secretedprotein of mouse adipose-derived stem cells, inhibits light-induced retinal degeneration. STEM CELLS Translational Medicine, 3:42-53, 2014.
  19. Ono Y., Tanaka H., Takata M., Nagahara Y., Noda Y., Tsuruma K., Shimazawa M., Hozumi I., Hara H. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neuroscience Letters, 559, 174-178, 2014.
  20. Morishita S., Oku H., Horie T., Tonari M., Kida T., Sugiyama T., Takai S., Hara H. and Ikeda T. Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of glial NF-κB activation. PLoS ONE, 9(1), e84387, 2014.

2013年（26報）

  1. Murase H., Shimazawa M., Kakino M., Ichihara K., Tsuruma K. and Hara H. The effects of Brazilian green propolis against excessive light-induced cell damage in retina and fibroblast cells. Evidence-Based Complementary and Alternative Medicine, 2013, Article ID 238279, 2013.
  2. Suzuki Y., Nakano Y., Mishiro K., Takagi T., Tsuruma K., Nakamura M., Yoshimura S., Shimazawa M. and Hara H. Involvements of Mincle and Syk on the changes in innate immune after ischemic stroke. Scientific Reports, 3: 3177, 2013.
  3. Ogawa K., Tsuruma K., Tanaka J., Kakino M., Kobayashi S., Shimazawa M. and Hara H. The protective effects of bilberry and lingonberry extracts against UV light-induced retinal photoreceptor cell damage in vitro. Journal of Agricultural and Food Chemistry, 61, 10345-10353, 2013.
  4. Otsuka T., Shimazawa M., Nakanishi T., Ohno Y., Inoue Y., Tsuruma K., Ishibashi T. and Hara H. The protective effects of a dietary carotenoid, astaxanthin, on light-induced retinal damage. Journal of Pharmacological Sciences, 123, 209-218, 2013.
  5. Sugitani S., Tsuruma K., Ohno Y., Kuse Y., Yamauchi M., Egashira Y., Yoshimura S., Shimazawa M., Iwama T. and Hara H. The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage. Experimental Eye Research, 116, 254-264, 2013.
  6. Egashira Y., Suzuki Y., Azuma Y., Takagi T., Mishiro K., Sugitani S., Tsuruma K., Shimazawa M., Yoshimura S., Kashimata M., Iwama T. and Hara H. The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment. J ournal of Neuroinflammation, 10: 105, 2013.
  7. Ishizuka F.#, Shimazawa M.#, Egashira Y., Ogishima H., Nakamura S., Tsuruma K. and Hara H. #: Contributed equally Cilostazol prevents retinal ischemic damage partly via inhibition of tumor necrosis factor-α-induced nuclear factor-kappa B/activator protein-1 signaling pathway. Pharmacology Research & Perspectives, 1, e00006, 2013.
  8. Ishizuka F.#, Shimazawa M.#, Inoue Y., Nakano Y., Ogishima H., Nakamura S., Tsuruma K., Tanaka H., Inagaki N. and Hara H. #: Contributed equally Toll-like receptor 4 mediates retinal ischemia/reperfusion injury through nuclear factor-kappa B and spleen tyrosine kinase activation. Invest. Ophthalmol. Vis. Sci., 54, 5807-5816, 2013.
  9. Takata M., Tanaka H., Kimura M., Nagahara Y., Tanaka K., Kawasaki K., Seto M., Tsuruma K., Shimazawa M. and Hara H. Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental amyotrophic lateral sclerosis models. British Journal of Pharmacology, 170, 341-351, 2013.
  10. Kasai H., Aoyama Y., Kurasawa T., Imamura T., Tsuruma K., Hara H., Hirata H. and Yamamoto T. Comparison of efficacy and safety evaluation of latanoprost formulations with and without benzalkonium chloride. Pharmacology & Pharmacy, 4, 377-384, 2013.
  11. Kitashoji A., Egashira Y., Mishiro K., Suzuki Y., Ito H., Tsuruma K., Shimazawa M. and Hara H. Cilostazol ameliorates warfarin-induced hemorrhagic transformation following cerebral ischemia in mice. Stroke, 44, 2862-2868, 2013.
  12. Ohno Y., Makita S., Shimazawa M., Tsuruma K., Yasuno Y. and Hara H. Thickness mapping of the inner retina by spectral-domain optical coherence tomography in an N-methyl-D-aspartate-induced retinal damage model. Experimental Eye Research, 113, 19-25, 2013.
  13. Inoue Y., Tsuruma K., Nakanishi T., Oyagi A., Ohno Y., Otsuka T., Shimazawa M. and Hara H. Role of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in light-induced photoreceptor degeneration in mouse retina. Invest. Ophthalmol. Vis. Sci., 54, 3815-3829, 2013.
  14. Ono Y., Tanaka H., Tsuruma K., Shimazawa M. and Hara H. A Sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochemical and Biophysical Research Communications, 434, 904-909, 2013.
  15. Shimazawa M., Nakamura S., Miwa M., Tsuruma K., Aihara M., Nakamura K. and Hara H. Establishment of the ocular hypertension model using the common marmoset. Experimental Eye Research, 111, 1-8, 2013.
  16. Ishisaka M., Tsuruma K., Shimazawa M., Shirai M., Saito N. and Hara H. Increased seizure susceptibility in a mouse with diacylglycerol kinase β deficiency. Neuroscience & Medicine, 4, 117-122, 2013.
  17. Nakamura S.#, Takizawa H.#, Shimazawa M.#, Hashimoto Y., Sugitani S., Tsuruma K. and Hara H. #: Contributed equally Mild endoplasmic reticulum stress promotes retinal neovascularization via induction of BiP/GRP78. PloS ONE, 8(3), e60517, 2013.
  18. Tanaka H., Shimazawa M., Takata M., Kaneko H., Tsuruma K., Ikeda T., Warita H., Aoki M., Yamada M., Takahashi H., Hozumi I., Minatsu H., Inuzuka T. and Hara H. ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis. Journal of Neurology, 260, 1782-1797, 2013.
  19. Ishizuka F., Shimazawa M., Umigai N., Ogishima H., Nakamura S., Tsuruma K. and Hara H. Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice. European Journal of Pharmacology, 703, 1-10, 2013.
  20. Takano N., Tsuruma K., Ohno Y., Shimazawa M. and Hara H. Bimatoprost protects retinal neuronal damage via Akt pathway. European Journal of Pharmacology, 702, 56-61, 2013.
  21. Tanaka J., Kadekaru T., Ogawa K., Hitoe S., Shimoda H. and Hara H. Maqui berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light. Food Chemistry, 139, 129-137, 2013.
  22. Hayashi T., Shimazawa M., Watabe H., Ose T., Inokuchi Y., Ito Y., Yamanaka H., Urayama S., Watanabe Y., Hara H. and Onoe H. Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma. Molecular Neurodegeneration, 8:4, 2013.
  23. Kasai, H., Imamura T., Tsuruma K., Takahashi Y., Kurasawa T., Hirata H., Shimazawa M. and Hara H. Effects of roscovitine, a cell cycling-dependent kinase inhibitor, on intraocular pressure of rabbit and retinal ganglion cell damage. Neuroscience Letters, 535, 95-99, 2013.
  24. Nakanishi T., Shimazawa M., Sugitani S., Kudo T., Imai S., Inokuchi Y., Tsuruma K. and Hara H. Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice. Journal of Neurochemistry, 125, 111-124, 2013.
  25. Tanaka J., Nakanishi T., Shimoda H., Nakamura S., Tsuruma K., Shimazawa M., Matsuda H., Yoshikawa M. and Hara H. Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo. Life Sciences, 92, 17-25, 2013.
  26. Mishiro K., Ishiguro M., Suzuki Y., Tsuruma K., Shimazawa M. and Hara H. Tissue plasminogen activator prevents restoration of tight junction proteins through upregulation of angiopoietin-2. Current Neurovascular Research, 10, 39-48, 2013.

2012年（27報）

  1. Tsuruma K., Shimazaki H., Ohno Y., Inoue Y., Honda A., Imai S., Lee J., Shimazawa M., Satoh M. and Hara H. Metallothionein-III deficiency exacerbates light-induced retinal degeneration. Invest. Ophthalmol. Vis. Sci., 53, 7896-7903, 2012.
  2. Morimoto N., Kita S., Shimazawa M., Namimatsu H., Tsuruma K., Hayakawa K., Mishima K., Egashira N., Iyoda T., Horie I., Gotoh Y., Iwasaki K., Fujiwara M., Matsuda T., Baba A., Komuro I., Horie K., Takeda J., Iwamoto T. and Hara H. Preferential involvement of Na+/Ca2+ exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice. Biochemical and Biophysical Research Communications, 429, 186-190, 2012.
  3. Suzuki Y., Hattori K., Hamanaka J., Murase T., Egashira Y., Mishiro K., Ishiguro M., Tsuruma K., Hirose Y., Tanaka H., Yoshimura S., Shimazawa M., Inagaki N., Nagasawa H., Iwama T. and Hara H. Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia. Scientific Reports, 2: 896, 2012.
  4. Kakino M., Izuta H., Tsuruma K., Araki Y., Shimazawa M., Ichihara K. and Hara H. Laxative effects and mechanism of action of Brazilian green propolis. BMC Complementary and Alternative Medicine, 12:192, 2012.
  5. Ono Y., Shimazawa M., Ishisaka M., Oyagi A., Tsuruma K. and Hara H. Imipramine protects mouse hippocampus against tunicamycin-induced cell death. European Journal of Pharmacology, 696, 83-88, 2012.
  6. Tsuruma K., Nishimura Y., Kishi S., Shimazawa M., Tanaka T. and Hara H. SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci., 53, 6729-6737, 2012.
  7. Tanaka H., Shimazawa M., Kimura M., Takata M., Tsuruma K., Yamada M., Takahashi H., Hozumi I., Niwa J., Iguchi Y., Nikawa T., Sobue G., Inuzuka T. and Hara H. The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis. Scientific Reports, 2: 573, 2012.
  8. Ohno Y., Nakanishi T., Umigai N., Tsuruma K., Shimazawa M. and Hara H. Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice. E uropean Journal of Pharmacology, 690, 84-89, 2012.
  9. Ito T., Kakino M., Tazawa S., Oyama M., Maruyama H., Araki Y., Hara H. and Iinuma M. Identification of phenolic compounds in Aquilaria crassna leaves via liquid chromatography-electrospray ionization mass spectroscopy. Food Science and Technology Research, 18, 259-262, 2012.
  10. Ishiguro M., Kawasaki K., Suzuki Y., Ishizuka F., Mishiro K., Egashira Y., Ikegaki I., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue prasminogen activator. Neuroscience, 220, 302-312, 2012.
  11. Kasai H., Ishisaka M., Shirasawa E. and Hara H. A three-dimensional collagen gel contraction monitoring system that uses a porcine trabecular meshwork for screening of anti-intraocular pressure agents. Pharmaceutica Analytica Acta, 3:154, 2012.
  12. Egashira Y., Sugitani S., Suzuki Y., Mishiro K., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. The conditioned medium of murine and human adipose-derived stem cells exerts neuroprotective effects against experimental stroke model. Brain Research, 1461, 87-95, 2012.
  13. Ishisaka M., Kakefuda K., Oyagi A., Ono Y., Tsuruma K., Shimazawa M., Kitaichi K. and Hara H. Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivity. PLoS ONE, 7(5), e37058, 2012.
  14. Nakamura S., Tsuruma K., Shimazawa M. and Hara H. Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression. European Journal of Pharmacology, 685, 8-14, 2012.
  15. Kakino M., Sugiyama T., Kunieda H., Tazawa S., Maruyama H., Tsuruma K., Araki Y., Shimazawa M., Ichihara K., Mori H. and Hara H. Agarwood (Aquilaria crassna) extracts decrease high-protein high-fat diet-induced intestinal putrefaction toxins in mice. Pharmaceutica Analytica Acta, 3:152, 2012.
  16. Shimazawa M., Miwa A., Ito Y., Tsuruma K., Aihara M. and Hara H. Involvement of endoplasmic reticulum stress in optic nerve degeneration following N-methyl-D-aspartate-induced retinal damage in mice. Journal of Neuroscience Research, 90, 1960-1969, 2012.
  17. Umigai N., Tanaka J., Tsuruma K., Shimazawa M. and Hara H. Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation. Current Neurovascular Research, 9, 102-109, 2012.
  18. Hong S., Hara H., Shimazawa M., Hyakkoku K., Kim C. Y., and Seong G. J. Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic artery. Brazilian Journal of Medical and Biological Research, 45, 212-215, 2012.
  19. Nakamura S., Imai S., Ogishima H., Tsuruma K., Shimazawa M. and Hara H. Morphological and functional changes in the retina after chronic oxygen-induced retinopathy. PLoS ONE, 7(2), e32167, 2012.
  20. Tsuruma K., Shimazaki H., Nakashima K., Yamauchi M., Sugitani S., Shimazawa M., Iinuma M. and Hara H. Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo. Molecular Nutrition & Food Research, 56, 713-724, 2012.
  21. Tsuruma K., Yamauchi M., Inokuchi Y., Sugitani S., Shimazawa M. and Hara H. Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice. Journal of Pharmacological Sciences, 118, 351-362, 2011.
  22. Mishiro K., Ishiguro M., Suzuki Y., Tsuruma K., Shimazawa M. and Hara H. A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice. Neuroscience, 205, 39-48, 2012.
  23. Shimazawa M., Ito Y., Inokuchi Y., Yamanaka H., Nakanishi T., Hayashi T., Ji B., Higuchi M., Suhara T., Imamura K., Araie M., Watanabe Y., Onoe H. and Hara H. An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: In vivo positron emission tomography imaging of glial activation. PLoS ONE, 7(1), e30526, 2012.
  24. Ito T., Kakino M., Tazawa S., Watarai T., Oyama M., Maruyama H., Araki Y., Hara H. and Iinuma M. Quantification of polyphenols and pharmacological analysis of water and ethanol-based extracts of cultivated agarwood leaves. Journal of Nutritional Science and Vitaminology, 58, 136-142, 2012.
  25. Murata K., Oyagi A., Takahira D., Tsuruma K., Shimazawa M., Ishibashi T., Hara H. Protective effects of astaxanthin from Paracoccus carotinifaciens on murine gastric ulcer models. Phytotherapy Research, 26, 1126-1132, 2012.
  26. Ito Y., Shimazawa M., Tsuruma K., Mayama C., Ishii K., Onoe H., Aihara M., Araie M. and Hara H. Induction of amyloid-β1-42 in the retina and optic nerve head of chronic ocular hypertensive monkeys. Molecular Vision, 18, 2647-2657, 2012.
  27. Tanaka J., Nakamura S., Tsuruma K., Shimazawa M., Shimoda H. and Hara H. Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis. Phytotherapy Research, 26, 214-222, 2012.

2011年（26報）

  1. Koumura A., Hamanaka J., Kawasaki K., Tsuruma K., Shimazawa M., Hozumi I., Inuzuka T. and Hara H. Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion. J. Pharmacol. Exp. Ther., 338, 337-344, 2011.
  2. Ogishima H., Nakamura S., Nakanishi T., Imai S., Kakino M., Ishizuka F., Tsuruma K., Shimazawa M. and Hara H. Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina. Invest. Ophthalmol. Vis. Sci., 52, 9710-9720, 2011.
  3. Tsuruma K., Tanaka Y., Shimazawa M., Mashima Y. and Hara H. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels. Molecular Vision, 17, 3556-3565, 2011.
  4. Hayashi E., Kobayashi T., Shiroshita Y., Kuratani K., Kinoshita M. and Hara H. An automated evaluation system for analyzing antinociceptive effects on intracolonic capsaicin-induced visceral pain-related licking behavior in mice. J. Pharmacol. Toxicol. Methods., 64, 119-123, 2011.
  5. Oyagi A., Moriguchi S., Nitta A., Murata K., Oida Y., Tsuruma K., Shimazawa M., Fukunaga K. and Hara H. Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation. Brain Res., 1419, 97-104, 2011.
  6. Shimazaki H., Hironaka K., Fujisawa T., Tsuruma K., Tozuka Y., Shimazawa M., Takeuchi H. and Hara H. Edaravone-loaded liposome eye drops protect against light-induced retinal damage in mice. Invest. Ophthalmol. Vis. Sci., 52, 7289-7297, 2011.
  7. Yoshikawa T., Ogata N., Izuta H., Shimazawa M., Hara H. and Takahashi K. Increased expression of tight junctions in APRE19 cells under endoplasmic reticulum stress. Current Eye Research, 36, 1153-1163, 2011.
  8. Ishisaka M., Kakefuda K., Yamauchi M., Tsuruma K., Shimazawa M., Tsuruta A. and Hara H. Luteolin shows an antidepressant-like effect via supressing endoplasmic reticulum stress. Biol. Pharm. Bull., 34, 1481-1486, 2011.
  9. Numajiri N., Takasawa K., Nishiya T., Tanaka H., Ohno K., Hayakawa W., Asada M., Matsuda H., Azumi K., Kamata H., Nakamura T., Hara H., Minami M., Lipton S. A. and Uehara T. On－off system for PI3-kinase－Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN). Proceedings of the National Academy of Sciences USA, 108, 10349-10354, 2011.
  10. Adachi T., Yasuda H., Nakamura S., Kamiya T., Hara H., Hara H. and Ikeda T. Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase. Free Radical Research, 45, 1083-1092, 2011.
  11. Uchibayashi R., Tsuruma K., Inokuchi Y., Shimazawa M. and Hara H. Involvement of Bid and caspase-2 in endoplasmic reticulum stress- and oxidative stress-induced retinal ganglion cell death. J. Neurosci. Res., 89, 1783-1794, 2011.
  12. Oyagi A., Morimoto N., Hamanaka J., Ishiguro M., Tsuruma K., Shimazawa M. and Hara H. Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury. Neuroscience, 185, 116-124, 2011.
  13. Ishiguro M., Suzuki Y., Mishiro K., Kakino M., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Blockade of phosphodiesterase-III protects against oxygen-glucose deprivation in endothelial cells by upregulation of VE-cadherin. Current Neurovascular Research, 8, 86-94, 2011.
  14. Hironaka K., Fujisawa T., Sasaki H., Tozuka Y., Tsuruma K., Shimazawa M., Hara H. and Takeuchi H. Fluorescence investigation of the retinal delivery of hydrophilic compounds via liposomal eyedrops. Biological and Pharmaceutical Bulletin, 34, 894-897, 2011.
  15. Hironaka K., Inokuchi Y., Fujisawa T., Shimazaki H., Akane M., Tozuka Y., Tsuruma K., Shimazawa M., Hara H. and Takeuchi H. Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage. European Journal of Pharmaceutics and Biopharmaceutics, 79, 119-125, 2011.
  16. Nakamura S., Morimoto N., Tsuruma K., Izuta H., Yasuda Y., Kato N., Ikeda T., Shimazawa M. and Hara H. Tissue kallikrein inhibits retinal neovascularization via the cleavage of vascular endothelial growth factor-165. Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 1041-1048, 2011.
  17. Hayashi E., Shimamura M., Kuratani K., Kinoshita M. and Hara H. Automated experimental system capturing three behavioral components during murine forced swim test. Life Sciences, 88, 411-417, 2011.
  18. Ogawa K., Oyagi A., Tanaka J., Kobayashi S. and Hara H. The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice. Phytotherapy Research, 25, 1160-1165, 2011.
  19. Nakamura S., Hayashi K., Takizawa H., Murase T., Tsuruma K., Shimazawa M., Kakuta H., Nagasawa H. and Hara H. An Arylidene-Thiazolidinedione Derivative, GPU-4, without PPARγ Activation, Reduces Retinal Neovascularization. Current Neurovascular Research, 8, 25-34, 2011.
  20. Ito Y., Shimazawa M., Inokuchi Y., Yamanaka H., Tsuruma K., Imamura K., Onoe H., Watanabe Y., Aihara M., Araie M. and Hara H. Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model. European Journal of Neuroscience, 33, 843-855, 2011.
  21. Tanaka J., Nakanishi T., Ogawa K., Tsuruma K., Shimazawa M., Shimoda H. and Hara H. Purple rice extract and anthocyanidins of the constituents protect light-induced retinal damage in vitro and in vivo. Journal of Agricultural and Food Chemistry, 59, 528-536, 2011.
  22. Ishisaka M., Kudo T., Shimazawa M., Kakefuda K., Oyagi A., Hyakkoku K., Tsuruma K. and Hara H. Restraint-induced expression of endoplasmic reticulum stress-related genes in the mouse brain. Pharmacology & Pharmacy, 2, 10-16, 2011.
  23. Nishioka Y., Oyagi A., Tsuruma K., Shimazawa M., Ishibashi T. and Hara H. The antianxiety-like effect of astaxanthin extracted from Paracoccus carotinifaciens. BioFactors, 37, 25-30, 2011.
  24. Tanaka H., Shimazaki H., Kimura M., Izuta H., Tsuruma K., Shimazawa M. and Hara H. Apoptosis-inducing factor and cyclophilin a cotranslocate to the motor neuronal nuclei in amyotrophic lateral sclerosis model mice. CNS Neuroscience and Therapeutics, 17, 294-304, 2011.
  25. Akane M., Shimazawa M., Inokuchi Y., Tsuruma K.and Hara H. SUN N8075, a novel radical scavenger, protects against retinal cell death in mice. Neurosci. Lett., 488, 87-91, 2011.
  26. Yamauchi M., Tsuruma K., Imai S., Nakanishi T., Umigai N., Shimazawa M. and Hara H. Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity. Eur. J. Pharmacol., 650, 110-119, 2011.

2010年（29報）

  1. Hayashi E., Kuratani K., Kinoshita M. and Hara H. Pharmacologically distinctive behaviors other than burying marbles during the marble burying test in mice. Pharmacology, 86, 293-296, 2010.
  2. Hyakkoku K., Hamanaka J., Tsuruma K., Shimazawa M. and Hara H. Proteomic approach with LCMS-IT-TOF identified an increase of Rab33B after transient focal cerebral ischemia in mice. Experimental & Translational Stroke Medicine, 2:29, 2010.
  3. Kakino M., Tazawa S., Maruyama H., Tsuruma K., Araki Y., Shimazawa M. and Hara H. Laxative effects of agarwood on low-fiber diet-induced constipation in rats. BMC Complementary and Alternative Medicine, 10: 68, 2010.
  4. Shimazawa M., Tanaka H., Ito Y., Morimoto N., Tsuruma K., Kadokura M., Tamura S., Inoue Y., Yamada M., Takahashi H., Warita H., Aoki M. and Hara H. An inducer of VGF protects cells from ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS. PLoS ONE, 5(12) : e15307, 2010.
  5. Ishiguro M., Mishiro K., Fujiwara Y., Chen H., Izuta H., Tsuruma K., Shimazawa M., Yoshimura S., Satoh M., Iwama T.and Hara H. Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tissue plasminogen activator. PLoS ONE, 5(12) : e15178, 2010.
  6. Kakefuda K,, Oyagi A., Ishisaka M., Tsuruma K., Shimazawa M., Yokota K., Shirai Y., Horie K., Saito N., Takeda J. and Hara H. Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS ONE, 5(10) : e13447, 2010.
  7. Honda A., Komuro H., Shimada A., Hasegawa T., Seko Y., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y. and Satoh M. Attenuation of cadmium-induced testicular injury in metallothionein-III null mice. Life Sciences, 87, 545-550, 2010.
  8. Imai S., Shimazawa M., Nakanishi T., Tsuruma K. and Hara H. Calpain inhibitor protects cells against light-induced retinal degeneration. J. Pharmacol. Exp. Ther., 335, 645-652, 2010.
  9. Hyakkoku K., Hamanaka J.,Tsuruma K., Shimazawa M., Tanaka H., Uematsu S., Akira S., Inagaki N., Nagai H. and Hara H. Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia. Neuroscience, 171, 258-267, 2010.
  10. Oida Y., Hamanaka J., Hyakkoku K., Shimazawa M., Kudo T., Imaizumi K., Yasuda T. and Hara H. Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice. Neurosci. Lett., 484, 43-46, 2010.
  11. Kawase K., Lin W., Aoyama Y., Yamamoto T., Shimazawa M. and Hara H. Effects of timolol-related ophthalmic solutions on cultured human conjunctival cells. Jpn. J. Ophthalmol., 54, 615-621, 2010.
  12. Oyagi A., Ogawa K., Kakino M. and Hara H. Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. BMC Complementary and Alternative Medicine, 10:45, 2010.
  13. Shirai Y., Kozuki T., Kakefuda K., Moriguchi S., Oyagi A., Horie K., Shimazawa M., Fukunaga K., Takeda J., Saito N. and Hara H. Essential role of diacylglycerol kinase beta (DGKβ) in neurite spine formation, cognitive function, and memory. PLoS ONE, 5(7) : e11602, 2010
  14. Maruyama H., Sakamoto T., Araki Y. and Hara H. Anti-inflammatory effect of bee pollen ethanol extract from Cistus sp. of Spanish on carrageenan-induced rat hind paw edema. BMC Complementary and Alternative Medicine, 10:30, 2010.
  15. Kakino M., Izuta H., Ito T., Tsuruma K., Araki Y., Shimazawa M., Oyama M., Iinuma M. and Hara H. Agarwood induces laxative effects via acetylcholine receptors on loperamide-induced constipation in mice. Biosci. Biotech. Biochem., 74, 1550-1555, 2010
  16. Imai S., Inokuchi Y., Nakamura S., Tsuruma K., Shimazawa M. and Hara H. Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina. Eur. J. Pharmacol., 642, 77-85, 2010
  17. Tsuruma K., Tanaka Y., Shimazawa M. and Hara H. Induction of amyloid precursor protein by the neurotoxic peptide, amyloid-beta 25-35, causes retinal ganglion cell death. Journal of Neurochemistry, 113, 1545-1554, 2010.
  18. Honda A., Komuro H., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y and Satoh M. Microarray analysis of the liver in metallothionein-III null mice treated with cadmium. The Journal of Toxicological Sciences, 35, 271-273, 2010.
  19. Honda A., Komuro H., Hasegawa T., Seko Y., Shimada A., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y and Satoh M. Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity. The Journal of Toxicological Sciences, 35, 209-215, 2010.
  20. Izuta H., Matsunaga N., Shimazawa M., Sugiyama T., Ikeda T. and Hara H. Proliferative diabetic retinopathy and relations among antioxidant activity, oxidative stress, and VEGF in the vitreous body. Mol. Vision, 16, 130-136, 2010.
  21. Inokuchi Y.,† Hironaka K.,† Fujisawa T., Tozuka Y., Tsuruma K., Shimazawa M., Takeuchi H. and Hara H, † contributed equally Physicochemical properties affecting retinal delivery of nanoparticulate systems via eyedrop administration. Invest. Ophthalmol. Vis. Sci., 51,3162-3170, 2010.
  22. Sato T., Oku H., Tsuruma K., Katsumura K., Shimazawa M., Hara H., Sugiyama T. and Ikeda T. Effect of Hypoxia on Susceptibility of RGC-5 Cells to Nitric Oxide. Invest. Ophthalmol. Vis. Sci., 51, 2575-258, 2010.
  23. Hino S., Kondo S., Yoshinaga K., Saito A., Murakami T., Kanemoto S., Sekiya H., Chihara K., Aikawa Y., Hara H., Kudo T., Sekimoto T., Funamoto T., Chosa E. and Imaizumi K. Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis. J. Bone and Mineral Metabolism, 28, 131-138, 2010.
  24. Chikaraishi Y., Izuta H., Shimazawa M., Mishima S. and Hara H. Angiostatic effects of Brazilian green propolis and its chemical constituents. Molecular Nutrition and Food Research, 54, 566-575, 2010.
  25. Matsunaga N., Tsuruma K., Shimazawa M., Yokota S. and Hara H. Inhibitory actions of Bilberry anthocyanidins on angiogenesis. Phytotherapy Research, 24, S42-S47, 2010.
  26. Ito Y., Nakamura S., Tanaka H., Tsuruma K., Shimazawa M., Araie M. and Hara H. Lomerizine, Ca2+-channel blocker, protects against neuronal degeneration within the visual center of the brain after retinal damage in mice. CNS Neuroscience and Therapeutics, 16, 103-114, 2010.
  27. Shimazawa M., Suemori S., Inokuchi Y., Matsunaga N., Nakajima Y., Oka T., Yamamoto T. and Hara H. A novel calpain inhibitor, ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945), reduces murine retinal cell death in vitro and in vivo. J. Pharmacol. Exp. Ther., 332, 380-387, 2010.
  28. Matsunaga N., Chikaraishi Y., Shimazawa M., Yokota S. and Hara H. Vaccinium myrtillus(Bilberry) extracts reduce angiogenesis in vitro and in vivo. eCAM, 7, 47-56, 2010. http://ecam.oxfordjournals.org/cgi/content/full/7/1/47
  29. Nakamura S., Chikaraishi Y., Tsuruma K., Shimazawa M. and Hara H. Ruboxistaurin, a PKCβ inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt. Exp. Eye Res., 90, 137-145, 2010.

2009年（27報）

  1. Izuta H.,Shimazawa M., Tsuruma K., Araki Y., Mishima S. and Hara H. Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells. BMC Complementary and Alternative Medicine, 9: 45, 2009. http://www.biomedcentral.com/1472-6882/9/45
  2. Izuta H., Chikaraishi Y., Adachi T., Shimazawa M., Sugiyama T., Ikeda T., and Hara H. Extracellular SOD and VEGF are increased in vitreous body from proliferative diabetic retinopathy patients. Mol. Vision, 15, 2663-2672, 2009. http://www.molvis.org/molvis/v15/a283/
  3. Oyagi A., Oida Y., Kakefuda K., Shimazawa M., Shioda N., Moriguchi S., Kitaichi K., Nanba D., Yamaguchi K., Furuta Y., Fukunag K., Higashiyama S. and Hara H. Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice. PLoS ONE, 4(10) : e7461, 2009.
  4. Koumura A., Kakefuda K., Honda A., Ito Y., Tsuruma K., Shimazawa M., Uchida Y., Hozumi I., Satoh M., Inuzuka T. and Hara H. Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors. Neurosci. Lett., 467, 11-14, 2009.
  5. Izuta H., Narahara Y., Shimazawa M., Mishima S., Kondo S. and Hara H. 1,1-Diphenyl-2-Picrylhydrazyl (DPPH) Radical Scavenging Activity of Bee Products and Their Constituents Determined by ESR Biol. Pharm. Bull., 32, 1947-1951, 2009.
  6. Ito Y., Yamada M., Tanaka H., Aida K., Tsuruma K., Shimazawa M., Hozumi I., Inuzuka T., Takahashi H. and Hara H. Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice. Neurobiology of Disease, 36, 470-476, 2009.
  7. Kakefuda K., Fujita Y., Oyagi A., Hyakkoku K., Kojima T., Umemura K., Tsuruma K., Shimazawa M., Ito M., Nozawa Y. and Hara H. Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection. Biochemical and Biophysical Research Communications, 387, 784-788, 2009.
  8. Koumura A., Hamanaka J., Shimazawa M., Honda A., Tsuruma K., Uchida Y., Hozumi I., Satoh M., Inuzuka T. and Hara H. Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia. Brain Res., 1292, 148-154, 2009.
  9. Maruyama H., Sumitou Y., Sakamoto T., Araki Y. and Hara H. Antihypertensive effects of flavonoids isolated from Brazilian green propolis in spontaneously hypertensive rats. Biol. Pharm. Bull., 32, 1244-1250, 2009.
  10. Chikaraishi Y., Shimazawa M., Yokota K., Yoshino K. and Hara H. CB-12181, a new azasugar-based matrix metalloproteinase/tumor necrosis factor-α converting enzyme inhibitor, inhibits vascular endothelial growth factor-induced angiogenesis in vitro and retinal neovascularization in vivo. Current Neurovascular Research, 6, 140-147, 2009.
  11. Nonaka Y., Koumura A., Hyakkoku K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Combination treatment with normobaric hyperoxia and cilostazol protects mice against focal cerebral ischemia-induced neuronal damage better than each treatment alone. J. Pharmacol. Exp. Ther., 330, 13-22, 2009.
  12. Ito Y., Shimazawa M., Chen Y. N., Tsuruma K., Yamashita T., Araie M. and Hara H. Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys. Exp. Eye Res., 89, 246-255, 2009.
  13. Tanaka H., Ito Y., Nakamura S., Shimazawa M. and Hara H. Involvement of brain-derived neurotrophic factor in time-dependent neurodegeneration in the murine superior colliculus after intravitreal injection of N-methyl-D-aspartate. Mol. Vision, 15, 662-669, 2009.
  14. Yamamoto T., Shibata N., Sukeguchi D., Takashima M., Nakamura S., Toru T., Matsunaga N., Hara H., Tanaka M., Obata T. and Sasaki T.Synthesis, configurational stability and stereochemical biological evaluations of (S)- and (R)-5-hydroxythalidomides. Bioorg. Med. Chem. Lett., 19, 3973-3976, 2009.
  15. Hironaka K., Inokuchi Y., Tozuka Y., Shimazawa M., Hara H. and Takeuchi H. Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye. J. Control. Release, 136, 247-253, 2009.
  16. Inokuchi Y., Imai S., Nakajima Y., Shimazawa M. and Hara H. Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo. J. Pharmacol. Exp. Ther., 329, 687-698, 2009.
  17. Nakajima Y., Tsuruma K., Shimazawa M., Mishima S. and Hara H. Comparison of bee products based on assays of antioxidant capacities. BMC Complement. Altern. Med., 9: 4, 2009. http://www.biomedcentral.com/1472-6882/9/4
  18. Nonaka Y., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage. Neurosci. Lett., 452, 156-161, 2009.
  19. Nakajima Y., Shimazawa M., Mishima S. and Hara H. Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis. Phytotherapy Research, 23, 1431-1438, 2009.
  20. Nakajima Y., Shimazawa M., Otsubo K., Ishibashi T. and Hara H. Zeaxanthin, a retinal carotenoid, protects retinal cells against oxidative stress. Curr. Eye Res., 34, 311-318, 2009.
  21. Hyakkoku K., NakajimaY., Izuta H., Shimazawa M., Yamamoto T., Shibata N. and Hara H. Thalidomide protects against ischemic neuronal damage induced by focal cerebral ischemia in mice. Neuroscience, 159, 760-769, 2009.
  22. Shimazawa M., Nakajima Y., Mashima Y. and Hara H. Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells Brain Res., 1251, 269-275, 2009.
  23. Matsunaga N., Imai S., Inokuchi Y., Shimazawa M., Yokota S., Araki Y. and Hara H. Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. Molecular Nutrition and Food Research, 53, 869-877, 2009.
  24. Imamura K., Onoe H., Shimazawa M., Nozaki S., Wada Y., Kato K., Nakajima H., Mizuma H., Onoe K., Taniguchi T., Sasaoka M., Hara H., Tanaka S., Araie M. and Watanabe Y. Molecular imaging reveals unique degenerative changes in experimental glaucoma. NeuroReport, 20, 139-144, 2009.
  25. Inokuchi Y., Shimazawa M., Nakajima Y., Komuro I., Matsuda T., Baba A., Araie M., Kita S., Iwamoto T. and Hara H. A Na+/Ca2+ exchanger isoform, NCX1, involves in retinal cell death after N-Methyl-D-aspartate and ischemia-reperfusion. J. Neurosci. Res., 87, 906-917, 2009.
  26. Izuta H., Chikaraishi Y., Shimazawa M., Mishima S. and Hara H. 10-Hydroxy-2-decenoic acid, a major fatty acid from Royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells. eCAM, 6, 489-494, 2009. http://ecam.oxfordjournals.org/cgi/content/abstract/6/4/489?etoc
  27. Inokuchi Y., Nakajima Y., Shimazawa M., Kurita T., Kubo M., Saito A., Sajiki H., Kudo T., Aihara M., Imaizumi K., Araie M. and Hara H. Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest. Ophthalmol. Vis. Sci., 50, 334-344, 2009.

2008年（20報）

  1. Koumura A., Nonaka Y., Hyakkoku K., Oka T., Shimazawa M., Hozumi I., InuzukaT. and Hara H. A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice. Neuroscience, 157, 309-318, 2008.
  2. Uchibayashi R., Yokoyama Y., Nakajima Y., Matsunaga N., Shimazawa M. and Hara H. Antiangiogenic effects of Chinese medicines (Hachimijiogan and Kogikujiogan) on vascular endothelial growth factor-A-induced tube formation in human umbilical vein endothelial cells co-cultured with fibroblasts. J. Complement. Integr. Med., 5, 1, 20, 2008.
  3. Izuta H., Shimazawa M., Tazawa S., Araki Y., Mishima S. and Hara H. Protective effects of Chinese propolis and its component, chrysin against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells. J. Agricul. Food Chem., 56, 8944-8953, 2008.
  4. Shimazawa M., Inokuchi Y., Okuno T., Nakajima Y., Sakaguchi G., Kato A., Oku H., Sugiyama T., Kudo T., Ikeda T., Takeda M. and Hara H. Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N- methyl-D-aspartate receptor signaling. J. Neurochem., 107, 279-290, 2008.
  5. Nakajima Y., Inokuchi Y., Shimazawa M., Otsubo K. Ishibashi T. and Hara H. Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in vitro and in vivo. J. Pharmacy & Pharmacology. 60, 1365-1374, 2008.
  6. Nakajima Y., Inokuchi Y., Nishi M., Shimazawa M., Otsubo K. and Hara H. Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo. Brain Res., 1226, 226-233, 2008.
  7. Nonaka Y., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice. Neurosci. Lett., 441, 224-228, 2008.
  8. Ito Y., Nakamura S., Tanaka H., Shimazawa M., Araie M. and Hara H. Memantine protects against secondary neuronal degeneration in lateral geniculate nucleus and superior colliculus after retinal damage in mice. CNS Neuroscience & Therapeutics, 14, 192-202, 2008.
  9. Matsunaga N., Chikaraishi Y., Izuta H., Ogata N., Shimazawa M., Matsumura M. and Hara H. Role of soluble vascular endothelial growth factor receptor-1 in the vitreous in proliferative diabetic retinopathy. Ophthalmology, 115, 1916-1922, 2008.
  10. Sasaoka M., Nakamura K., Shimazawa M., Ito Y., Araie M. and Hara H. Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model. Exp. Eye Res., 86, 770-782, 2008.
  11. Oida Y., Izuta H., Oyagi A., Shimazawa M., Kudo T., Imaizumi K. and Hara H. Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res., 1208, 217-224, 2008.
  12. Yamamoto T., Shibata N., Takashima M., Nakamura S., Toru T., Matsunaga N. and Hara H. Enzymatic resolution and evaluation of enantiomers of cis-5′-hydroxythalidomide. Org. Biomol. Chem., 6, 1540-1543, 2008.
  13. Ito Y., Shimazawa M., Inokuchi Y., Fukumitsu H., Furukawa S., Araie M. and Hara H. Degenerative alterations in the visual pathway after NMDA-induced retinal damage in mice. Brain Res., 1212, 89-101, 2008.
  14. Oyagi A., Oida Y., Hara H., Izuta H., Shimazawa M., Matsunaga N., Adachi T. and Hara H. Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease. Brain Res., 1214, 169-176, 2008.
  15. Hara H., Ise Y., Morimoto N., Shimazawa M., Ichihashi K., Ohyama M. and Iinuma M. Laxative effect of agarwood leaves and its mechanism. Biosci. Biotech. Biochem., 72, 335-345, 2008.
  16. Kotani Y., Nakajima Y., Hasegawa T., Satoh M., Nagase H., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Propofol exerts greater neuroprotection with disodium edetate than without it. J. Cereb. Blood Flow & Metabol., 28, 354-366, 2008.
  17. Matsunaga N., Shimazawa M., Otsubo K. and Hara H. Phosphatidylinositol inhibits vascular endothelial growth factor-A-induced migration of human umbilical vein endothelial cells. J. Pharmacol. Sci., 106, 128-135, 2008.
  18. Kudo T., Kanemoto S., Hara H., Morimoto N., Morihara T., Kimura R., Tabira T., Imaizumi K and Takeda M. A molecular chaperone inducer protects neurons from ER stress. Cell Death and Differentiation, 15, 364-375, 2008.
  19. Oida Y., Shimazawa M., Imaizumi K. and Hara H. Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil. Neuroscience, 151, 111-119, 2008.
  20. Chikaraishi Y., Matsunaga N., Shimazawa M. and Hara H. Rifampicin inhibits the retinal neovascularization in vitro and in vivo. Exp. Eye Res., 86, 131-137, 2008

2007年（9報）

  1. Kotani Y., Morimoto N., Oida Y., Tamura Y., Tamura S., Inoue T., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Prevention of in vitro and in vivo acute ischemic neuronal damage by (2S)-1-(4-Amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl) phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate (SUN N8075), a novel neuroprotective agent with antioxidant properties. Neuroscience, 149, 779-788, 2007.
  2. Wakida K., Shimazawa M., Satoh M., Nagase H., Imaizumi T. and Hara H. Neuroprotective effect of erythropoietin, and role of metallothionei-1 and -2, in permanent focal cerebral ischemia. Neuroscience, 148, 105-114, 2007.
  3. Morimoto N., Oida Y., Shimazawa M., Miura M., Kudo T., Imaizumi K. and Hara H. Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice. Neuroscience, 147, 957-967, 2007.
  4. Yamashita K., Kotani Y., Nakajima Y., Shimazawa M., Yoshimura S., Nakashima S., Iwama T. and Hara H. Fasudil, a Rho kinase(ROCK) inhibitor, protects against ischemic neuronai damage in vitro and in vivo by acting directly on neurons. Brain Res., 1154, 215-224, 2007.
  5. Shimazawa M., Ito Y., Inokuchi Y. and Hara H. Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage. Invest. Ophthalmol. Vis. Sci., 48, 3729-3736, 2007.
  6. Kondo S., Saito A., Hino S., Murakami T., Ogata M., Kanemoto S., Nara S., Yamashita A., Hara H. and Imaizumi K. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of ER stress transducer. Mol. Cell. Biol., 27, 1716-1729, 2007.
  7. Shimazawa M., Inokuchi Y., Ito Y., Murata H., Aihara M., Miura M., Araie M. and Hara H. Involvememt of ER stress in retinal cell death. Mol. Vision, 13, 578-587, 2007.
  8. Chikaraishi Y., Shimazawa M. and Hara H. New quantitative analysis, using high-resolution images, of oxygen-induced retinal neovascularization in mice. Exp. Eye Res., 84, 529-536, 2007.
  9. Nakajima Y., Shimazawa M., Mishima S. and Hara H. Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects vis antioxidant actions. Life Sci., 80, 370-377, 2007.

2006年（13報）

  1. Shimazawa M. amd Hara H. Inhibitor of double stranded RNA-dependent proteinkinase protects against cell damage induced by ER stress. Neurosci. Lett., 409, 192-195, 2006.
  2. Ito Y., Shimazawa M., Akao Y., Nakajima Y., Seki N., Nozawa Y. and Hara H. Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo. J. Pharmacol. Sci., 102, 196-204, 2006.
  3. Wakida K., Morimoto N., Shimazawa M., Hozumi I., Nagase H., Inuzuka T. and Hara H. Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2. Brain Res., 1116, 187-193, 2006.
  4. Suemori S., Shimazawa M., Kawase K., Satoh M., Nagase H., Yamamoto T. and Hara H. Metallothionein, an endogeneous antioxidant, protects against retinal neuron damage in mice. Invest. Ophthalmol. Vis. Sci., 47, 3975-3982, 2006.
  5. Hara H., Oh-hashi K., Yoneda S., Shimazawa M., Inatani M., Tanihara H. and Kiuchi K. Elevated neprilysin activity in vitreous of patients with proliferative diabetic retinopathy. Mol. Vision, 12, 977-982, 2006.
  6. Oida Y., Kitaichi K., Nakayama H., Ito Y., Fujimoto Y., Shimazawa M., Nagai H. and Hara H. Rifampicin attenuates the MPTP-induced neurotoxicity in mouse brain. Brain Res., 1082, 196-204, 2006.
  7. Inokuchi Y., Shimazawa M., Nakajima Y., Suemori S., Mishima S. and Hara H. Brazilian green propolis protects against retinal damage in vitro and in vivo. eCAM, 3, 71-77, 2006.
  8. Shimazawa M., Tomita G., Taniguchi T., Sasaoka M., Hara H., Kitazawa Y. and Araie M. Morphometric evaluation of changes with time in optic disc structure and thickness of retinal nerve fibre layer in chronic ocular hypertensive monkeys. Exp. Eye Res., 82, 427-440, 2006.
  9. Shimazawa M., Taniguchi T., Sasaoka M. and Hara H. Nerve fiber layer measurememt using scanning laser polarimetry with fixed corneal compensator in normal cycnomolgus monkey eyes. Ophthalmic Res., 38, 1-7, 2006.
  10. Taniguchi T., Shimazawa M., Sasaoka M. and Hara H. Endothelin-1 impairs retrograde axonal transport and leads to axonal injury in rat optic nerve. Curr. Neurovasc. Res., 3, 81-88, 2006.
  11. Sasaoka M., Taniguchi T., Shimazawa M., Ishida N., Shimazaki A. and Hara H. Intravitreal injection of endotheline-1 caused optic nerve damage following to ocular hypoperfusion in rabbits. Exp. Eye Res., 82, 427-440, 2006.
  12. Komine-Kobayashi M., Zhang N., Liu M., Tanaka R., Hara H., Osaka A., Mochizuki H., Mizuno Y. and Urabe T. Neuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of mice. J. Cereb. Blood Flow & Metabol., 26, 402-413, 2006.
  13. Tsuruma K., Nakagawa T., Morimoto N., Minami M., Hara H., Uehara T. and Nomura Y. Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury. J. Biol. Chem., 281, 11397-11404, 2006.

2005年（11報）

  1. Shimazawa M., Watanabe S., Kondo K., Hara H.., Nakashima M. and Umemura K. Neutrophil accumulation promotes intimal hyperplasia after photochemically induced arterial injury in mice. Eur. J. Pharmacol., 520, 156-163, 2005.
  2. Shimazawa M., Kondo K., Hara H., Nakashima M. and Umemura K. Sulfatides, L-and P-selectin ligands, exacerbate the intimal hyperplasia occurring after endothelial injury. Eur. J. Pharmacol., 520, 118-126, 2005.
  3. Akaishi T., Ishida N., Shimazaki A., Hara H. and Kuwayama Y. Continuous monitoring of circadian variations in intraocular pressure by telemetry system throughout 12 weeks' treatment with timolol maleate in rabbits. J. Ocul. Pharmacol. Ther., 21, 436-444, 2005.
  4. Shimazawa M., Yamashita T., Agarwal N. and Hara H. Neuroprotective effects minocycline against in vitro and in vivo retinal ganglion cell damage. Brain Res., 1053, 185-194, 2005.
  5. Taniguchi T., Shimazawa M., Araie M., Tomita G., Sasaoka M., Kitazawa Y. and Hara H. Optic disc topographic parameters measured in the normral cynomolgus monkey by confocal scanning laser tomography. Br. J. Ophthalmol., 89, 1058-1062, 2005.
  6. Shimazawa M., Chikamatsu S., Morimoto N., Mishima S., Nagai H. and Hara H. Neuroprotection by Brazilian green propolis in vitro and in vivo ishemic neuronal damage. eCAM, 2, 201-207, 2005.
  7. Sasaoka M., Hara H. and Nakamura K. Comparison between monkey and human visual fields using a personal computer system. Behavioral Brain Res., 161, 18-30, 2005.
  8. Shimazawa M., Miyake Y., Yamaguchi T., Yokota K., Sukamoto T. and Hara H. Effect of pamicogrel, a new antiplatelet drug, on the progression of sodium laurate-induced arterial occlusive in guinea pigs. Jpn. J. Thromb. Hemost., 16, 212-221, 2005.
  9. Yoneda S., Shimazawa M., Kato M., Nonoyama A., Torii Y., Nishino H., Sugimoto N., Kozaki S. and Hara H. Comparison of the therapeutic indexes of different molecular forms of botulinum toxin type A. Eur. J. Pharmacol., 508, 223-229, 2005.
  10. Morimoto N., Shimazawa M., Yamashita T., Nagai H. and Hara H. Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage. Brain Res., 1044, 8-15, 2005.
  11. Yoneda S., Hara H., Hirata A., Fukushima M., Inomata Y. and Tanihara H. Vitreous fluid levels of β-amyloid(1-42) and Tau in patients with retinal diseases. Jpn. J. Ophthalmol., 49, 106-108, 2005.

2004年（14報）

  1. Oku H.,Goto W., Kobayashi T., Okuno T., Hirano M., Sugiyama T., Yoneda S., Hara H. and Ikeda T. Adenosine protects cultured retinal neurons agonist NMDA-induced cell death through A1 receptors. Curr. Eye Res., 29, 449-488, 2004.
  2. Oku H., Goto W., Okuno T., Kobayashi T., Sugiyama T., Ota T., Yoneda S., Hara H. and Ikeda T. Effects of poly(ADP-ribose) polymerase inhibitor on NMDA-induced retinal injury. Curr. Eye Res., 29, 403-411, 2004.
  3. Matsugi T., Takagi Y., Nakajima T., Goto W., Kageyama M., Mori N., Matsunuma Y. and Hara H. Prostanoid FP-receptor agonistic activities and ocular hypotensive effects of 15,15-difluoro prostaglandin F2α derivatives. Jpn. J. Ocular Pharmacol., 18, 74-76, 2004.
  4. Taniguchi T., Shimazawa M. and Hara H. Change in phosphorylated neurofilament heavy chain in the rat kainite-induced optic nerve damage. J. Eye 21, 1101-1104, 2004.
  5. Matsumura Y., Mori N., Nakano T., Sasakura H., Matsugi T., Hara H. and Morizawa Y. Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168: a novel 15-deoxy15,15,-difluoroprostaglandin F2α derivative. Tetrahedron Lett., 45, 1527-1529, 2004.
  6. Shimazaki A., Ichikawa M., Rao P. O., Kirihara T., Konomi K., Epstein D. L. and Hara H. Effects of the new ethacrynic acid derivative SA9000 on intraocular pressure in cats and monkeys. Biol. Pharm. Bull., 27, 1019-1024, 2004.
  7. Shimazaki A., Suhara H., Ichikawa M., Matsugi T., Konomi K., Takagi Y., Hara H., Rao P. O. and Epstein D. L. New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells. Biol. Pharm. Bull., 27, 846-850, 2004.
  8. Goto W., Ichikawa M., Tanaka E., Hara H. and Araie M. Bunazosin hydrochloride reduces glutamate-induced neurotoxicity in rat primary retinal cultures. Brain Res., 1003, 130-137, 2004.
  9. Akashi T., Takagi Y., Matsugi T., Ishida N., Hara H. and Kashiwagi K. Effects of bunazosin hydrochloride on ciliary muscle constriction and matrix metalloproteinase activities. J. Glaucoma, 13, 312-318, 2004.
  10. Okada Y., Ichikawa M., Ishii K. and Hara H. Effects of topically instilled bunazosin hydrochloride and other ocular hypotensive drugs on endothelin-1-induced constriction in rabbit retinal arteries. Jpn. J. Ophthalmol., 48, 465-469, 2004.
  11. Takagi Y., Nakajima T., Shimazaki A., Kageyama M., Matsugi T., Matsumura Y., Gabelt B. T., Kaufman P. L. and Hara H. Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp. Eye Res., 78, 767-776, 2004.
  12. Yamamoto R., Yoneda S. and Hara H. Neuroprotective effects of β-secretase inhibitors against rat retinal ganglion cell death. Neurosci. Lett., 370, 61-64, 2004.
  13. Taniguchi T., Shimazawa M. and Hara H. Alterrations in neurofilament light in optic nerve in rat kainate and monkey ocular hypertension models. Brain Res., 1013, 241-248, 2004.
  14. Ichikawa M., Okada Y., Hara H., Ishii K. and Araie M. Effects of topically bunazosin, an α1-adrenoceptor antagonist, on constrictions induced by phenylephline and ET-1 in rabbit retinal arteries. Invest. Ophthalmol. Vis. Sci., 45, 4041-4048, 2004.

2003年以前（82報）

  1. Nakajima T., Matsugi T., Goto W., Kageyama M., Mori N., Matsumura Y. and Hara H. New fluoroprostaglandin F2α derivatives with prostanoid FP-receptor agonistic acivity as potent ocular-hypotensive agents. Biol. Pharm. Bull., 26, 1691-1695, 2003.
  2. Akaishi T., Shimazaki A., Matsugi T., Miyawaki N., Hara H. and Kuwayama Y. Effects of ocular hypotensive agents on the circadian rhythm in itraocular pressure in rabbits as measured by teremetry. Nippon Ganka Gakkai Zasshi, 107, 513-518, 2003.
  3. Yoneda S., Tanaka E., Goto W., Ota T. and Hara H. Topiramate reduces excitotoxic and ischemic injury in the rat retina. Brain Res., 967, 257-266, 2003.
  4. Goto W., Ota T., Morikawa N., Otori Y., Hara H., Kawazu K., Miyawaki N. and Tano Y. Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina. Brain Res., 958, 10-19, 2002.
  5. Ota T., Hara H. and Miyawaki N. Brain-derived neurotrophic factor inhibits changes in soma-size of retinal ganglion cells following optic nerve axotomy in rats. J. Ocul. Pharmacol. Ther., 18, 241-249, 2002.
  6. Yoneda S., Tanihara H., Kido N., Honda Y., Goto W., Hara H. and Miyawaki N. Interleukin-1β mediates ischemic injury in the rat retina. Exp. Eye Res., 73, 661-667, 2001.
  7. Kido N., Inatani M., Honjo M., Yoneda S., Hara H., Miyawaki N., Honda Y. and Tanihara H. Dual effects of interleukin-1β on N-methyl-D-aspartate-induced retinal neuronal death in rat eyes. Brain Res., 910, 153-162, 2001.
  8. Sugiyama T., Hara H., Oku H., Nakatsuji S., Okuno T., Sasaoka M., Ota T. and Ikeda T. Optic cup enlargement followed by reduced optic nerve head circulation after optic nerve stimulation. Invest. Ophthalmol. Vis. Sci., 42, 2843-2848, 2001.
  9. Ota T., Hara H. and Miyawaki N. Quantitative analysis of retinal ganglion cell damage following optic nerve axotomy in rats. Jpn. J. Ocular Pharmacol., 15, 29-30, 2001.
  10. Toriu N., Sasaoka M., Shimazawa M., Sugiyama T. and Hara H. Effects of Lomerizine, a novel Ca2+ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits. J. Ocul. Pharmacol. Ther., 17,131-149, 2001.
  11. Kang S., Wang S., Hara H., Peterson E. P., Namura S., Amin-Hanjani S., Huang Z., Srinivasan A., Tomaselli K. J., Thornberry N. A., Moskowitz M. A. and Yuan J. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J. Cell Biol., 149, 613-622, 2000.
  12. Shibata M., Hisahara S., Hara H., Yamawaki T., Fukuuchi Y., Yuan J., Okano H. and Miura M. Caspases determine the vulnerability of oligodendrocytes in the ischemic brain. J. Clin. Invest., 106, 643-653, 2000.
  13. Toriu N., Akaike A., Yasuyoshi H., Zhang S., Kashii S., Honda Y., Shimazawa M. and Hara H. Lomerizine, Ca2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rrat retina. Exp. Eye Res., 70, 475-484, 2000.
  14. Hara H., Shimazawa M., Sasaoka M., Yamada C., Iwakura Y., Sakai T., Maeda Y., YamaguchiT., Sukamoto T. and Hashimoto M. Selective effects of lomerizine, a novel diphenylmethylpiperazine Ca2+ channel blocker, on cerebral blood flow in rats and dogs. Clin. Exp. Pharmacol. Physiol., 26, 870-876, 1999.
  15. Shimazawa M., Sugiyama T., Azuma I., Araie M., Iwakura Y., Watari M., Sakai T. and Hara H. Effects of lomerizine, a new Ca2+ channel blocker, on the microcirculation of optic nerve head in conscious rabbits using a laser speckle technique. Exp. Eye Res., 69, 185-193, 1999.
  16. Hara H., Shimazawa M., Hashimoto M. and Sukamoto T. Anti-migraine effects of lomerizine. Folia Pharmacol. Japon, 112, 138-142, 1998.
  17. Bergeron L., Perez G. I., MacDonald G., Shi L., Sun Y., Jurisicova A., Varmuza S., Latham K. E., Flaws J. A., Salter J. C., Hara H., Moskowitz M. A., Li E., Greenberg A., Tilly J. L. and Yuan J. Defects in regulation of apoptosis in caspase-2-deficient mice. Genes and Development, 12, 1304-1314, 1998.
  18. Ofuji K., Hara H., Sukamoto T. and Yamashita S. Effects of an antidiarrhoeica containing an extract from Geranium Herb on astringent action and short-circuit current asross jejunal mucosa. Folia Pharmacol. Japon, 111, 265-275, 1998.
  19. Ayata C., Ayata G., Hara H., Mattews R. T., Beal M. F., Ferrante R. J., Endres M., Kim A., Christie R. H., Waeber C., Huang P. L., Hyman B. T. and Moskowitz M. A. Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice. J Neurosci., 17, 6908-6917, 1997.
  20. Friedlander R. M., Gagliardini V., Hara H., Fink K. B., Li W., MacDonald G., Fishman M. C., Greenberg A. H., Moskowitz M. A. and Yuan J. Expression of a dominant negative mutant of ICE in transgenic mice prevents neuronal cell death induced by trophic factotr withdrawal and ischemic brain injury. J. Exp. Med., 185, 933-940, 1997.
  21. Watano T., Hara H. and Sukamoto T. Inhibitory effect of lomerizine, a diphenylpiperazine Ca2+-channel blocker, on Ba2+ current through voltage-gated Ca2+ channels in PC12 calls. Jpn. J. Pharmacol., 75, 209-213, 1997.
  22. Fujii M., Hara H., Meng W., Vonsattel J. P., Huang Z. and Moskowitz M. A. Strain-related differences in susceptibility to transient forebrain ischemia in SV-129 and C57black/6 mice. Stroke, 28, 1805-1811, 1997.
  23. Zaharachuck G., Hara H., Huang P. L., Fishman M. C., Moskowitz M. A., Jenkins B. G. and Rosen B. R. Neuronal nitric oxide synthase mutant mice show smaller infarcts and attenuated apparent diffusion coefficient changes in the peri-infarct zone during focal cerebral ischemia. Mag. Reson. Imag., 37, 170-175, 1997.
  24. Hara H., Fink K., Endres M., Friedlander R. M., Gagliardini V., Yuan J. and Moskowitz M. A. Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein. J. Cereb. Blood Flow & Metabol., 17, 370-375, 1997.
  25. Hara H., Ayata G., Huang P. L. and Moskowitz M. A. Alteration of protein kinase C activity binding after transient focal cerebral ischemia in mice using in vitro [3H]phorbol-12,13-dibutyrate binding autoradiography. Brain Res., 774, 69-76, 1997.
  26. Hara H., Ayata C., Huang P. L., Waeber C., Ayata G., Fujii M. and Moskowitz M. A. [3H]L-NG-Nitro-arginine binding after transient focal ischemia and NMDA-induced excitotoxicity in type I and type III nitric oxide synthase null mice. J. Cereb. Blood Flow & Metabol., 17, 515-526, 1997.
  27. Hara H., Friedlander R. M., Gagliardini V., Ayata C., Fink K., Huang Z., Shimizu-Sasamata M., Yuan J. and Moskowitz M. A. Effects of inhibition of the ICE family proteases on ischemic and excitotoxic neuronal damage. Proc. Natl. Acd. Sci., U.S.A., 94, 2007-2012, 1997.
  28. Meng W., Ma J., Ayata C., Hara H., Huang P. L., Fishman M. C. and Moskowitz M. A. Ach dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms. Am J. Physiol., 271, H1145-H1150, 1996.
  29. Yamaguchi T., Hara H., Harada Y., sakita Y. and Sukamoto T. The effects of naftopidil on blood pressure, heart rate and plasma norepinephrine level in freely moving rabbits. Jpn. Pharmacological.Ther., 24, 49-53, 1996.
  30. Lo E., Hara H., Rogowska J., Trocha M., Pierce A. R., Huang P. L., Fishman M. V., Wolf G. L. and Moskowitz M. A. Temporal correlation mappping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression. Stroke, 27, 1381-1385, 1996.
  31. Shimazawa M. and Hara H. An experimental model of migraine with aura: cortical hypoperfusion following spreading depression in the awake and freely moving rat. Clin. Exp. Pharmacol. Physiol., 23, 890-892, 1996.
  32. Hara H., Waeber C., Huang P. L., Fujii M., Fishman M. C. and Moskowitz M. A. Brain distribution of nitric oxide synthase in neuronal or endothelial nitric oxide synthase mutant mice using [3H]L-NG-nitro-arginice autoradiography. Neuroscience, 75, 881-890, 1996.
  33. Hara H., Huang P. L., Panahian N., Fishman M. C. and Moskowitz M. A. Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J. Cereb. Blood Flow & Metabol., 16, 605-611, 1996.
  34. Watano T., Hara H., Yamashita A. and Sukamoto T. Effects of Dokkatsu-kakkon-to on the blood flow in the femoral skeletal muscle in anesthetized rats. J. Traditional Med., 12, 154-159, 1995.
  35. Shimazawa M., Hara H., Watano T. and Sukamoto T. Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats. Br. J. Pharmacol., 115, 1359-1368, 1995.
  36. Morimoto Y., Shimohara K., Tanaka K., Hara H. and Sukamoto T. 4-Methoxyphenyl 4-(3,4,5-trimethoxybenzyl) -1-piperazineacetate monofumarate monohydrate (KB-5492), a new anti-ulcer agent with a selective affinity for the sigma receptor,prevents cysteamine-induced duodenal ulcers in rats by a mechanism different from that of cimetidine. Jpn. J. Pharmacol., 64, 221-224, 1994.
  37. Morimoto Y., Shimohara K., Oshima S., Hara H. and Sukamoto T. Effects of KB-5492, a new anti-ulser agent with a selective affinity for the sigma-receptor, on aspirin-induced distribution of the rat gastric mucosal barrier. Jpn. J. Pharmacol., 64, 49-55, 1994.
  38. Morimoto Y., Oshima S., Hara H. and Sukamoto T. Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro. Jpn. J. Pharmacol., 64, 41-47, 1994.
  39. Kato H., Araki T., Hara H. and Kogure K. Regional changes in [3H]inositol 1,4,5-triphosphate binding in the gerbil brain following repeated sublethal ischemia. Brain Res. Bull., 33, 465-468, 1994.
  40. Watano T., Tanaka K., Hara H. and Sukamoto T. Analgesic effects of an antidepressant, trazodone hydrochloride (Reslin). J. Med. Pharmaceutical Sci., 32, 45-53, 1994.
  41. Fujishima Y., Hara H., Shimazawa M., Yokota K. and Sukamoto T. The effects of novel Ca2+ channel blocker, KB-2796, on 5-HT-induced responses. Folia Pharmacol. Jpn., 104, 19-29, 1994.
  42. Harada Y., Hara. and Sukamoto T. Binding properties of KB-5492, a novel anti-ulcer agent, at sigma receptors in porcine gastric fundic mucosa. Eur. J. Pharmacol., 261, 91-96, 1994.
  43. Harada Y., Hara H. and Sukamotoo T. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur. J. Pharmacol., 256, 321-328, 1994.
  44. Harada Y., Hara H. and Sukamoto T. Characterization of specific (+)-[3H]N-allylnormetazocine and [3H]1,3-di(2-tolyl)guanidine binding sites in porcine gastric fundic mucosa. J. Pharmacol. Exp. Ther., 269, 905-910, 1994.
  45. Hara H., Tanaka K., Harada Y. and Sukamoto T. Sigma receptor-mediated effects of a new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric alkaline secreation in rats. J. Pharmacol. Exp. Ther., 269, 799-805, 1994.
  46. Morita T., Yamashita A., Morimoto Y., Saito T., Nishimura N., Yokota K., Hara H., Ikegami K., Harada A., Imamura A., Sukamoto T., Ito K. and Nurimoto S. General pharmacology of a novel Ca2+ antagonist, 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796). Pharmacometrics, 46, 243-260, 1993.
  47. Yamashita A., Ozaki A., Ikegami A., Hayashi A., Hara H., Sukamoto T. and Ito K. Effects of a new diphenylpiperazine calcium antagonist, KB-2796, on cerebral ischemic neuronal damages in rats. Gen. Pharmacol. 24, 1473-1480, 1993.
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