岐阜薬科大学
生化学研究室

原著論文

原著論文
Original papers

2024年

  • Yoshino, Y., Teruya, T., Miyamoto, C., Hirose, M., Endo, S., Ikari, A., Unraveling the Mechanisms Involved in the Beneficial Effects of Magnesium Treatment on Skin Wound Healing. Int J Mol Sci., 25(9):4994 (2024)
  • Eguchi, H., Yu, Y., Matsunaga, T., Yoshino, Y., Ikari, A., Acrolein suppresses anticancer drug-induced toxicity mediated by activating claudin-1 and Nrf2 axis in a spheroid model of human lung squamous cell carcinoma cells. Toxicol Lett., 392, 46-55 (2024)
  • Himura, R., Kawano, S., Nagata, Y., Kawai, M., Ota, A., Kudo, Y., Yoshino, Y., Fujimoto, N., Miyamoto, H., Endo, S., Ikari, A., Inhibition of aldo-keto reductase 1C3 overcomes gemcitabine/cisplatin resistance in bladder cancer cells. Chem. Biol. Interact., 388, 110840 (2024)

2023年

  • Fujimoto, A., Koutake, Y., Hisamatsu, D., Ookubo, N., Yabuuchi, Y., Kamimura, G., Kai, T., Kozono, A., Ootsu, T., Suzuki, H., Matsuo, K., Kuwahara, K., Oiwane, Y., Nagata, Y., Tanimoto, K., Sato, E., Suenaga, M., Uehara, T., Ikari, A., Endo, S., Hiraki, Y., Kawamata, Y., Risk factors indicating immune-related adverse events with combination chemotherapy with immune checkpoint inhibitors and platinum agents in patients with non-small cell lung cancer: a multicenter retrospective study. Cancer Immunol. Immunother., 72, 2169-2178 (2023)
  • Okamoto, E., Matsuda, S., Yoshino, Y., Morikawa, Y., Suenami, K., Tabuchi, Y., Matsunaga, T., Ikari, A., Regulation of paracellular fluxes of amino acids by claudin-8 in normal mouse intestinal MCE301 cells. Nutrients., 15, 1346 (2023)
  • Nakamura, C., Ishizuka, N., Yokoyama, K., Yazaki, Y., Tatsumi, F., Ikumi, N., Hempstock, W., Ikari, A., Yoshino, Y., Hayashi, H., Regulatory mechanisms of glucose absorption in the mouse proximal small intestine during fasting and feeding. Sci. Rep., 13, 10838 (2023)
  • Okamoto, E., Matsuda, S., Yoshino, Y., Morikawa, Y., Suenami, K., Tabuchi, Y., Matsunaga, T., Hayashi, H, Ikari, A., Increase in paracellular leakage of amino acids mediated by aging-induced reduction of claudin-4 expression. J. Nutr., S0022-3166, 72621-72627 (2023)
  • Nagaoka, Y., Oshiro, K., Yoshino, Y., Matsunaga, T., Endo, S., Ikari, A., Activation of the TGF-β1/EMT signaling pathway by claudin-1 overexpression reduces doxorubicin sensitivity in small cell lung cancer SBC-3 cells. Arch. Biochem. Biophys., 751, 109824 (2023)
  • Sakai, Y., Egawa, D., Hattori, J., Morikawa, Y., Suenami, K., Takayama, T., Nagai, A., Michiue, T., Ikari, A., Matsunaga, T., α-Pyrrolidinononanophenone derivatives induce differentiated SH-SY5Y neuroblastoma cell apoptosis via reduction of antioxidant capacity: Involvement of NO depletion and inactivation of Nrf2/HO1 signaling pathway. Neurotoxicity., 100, 3-15 (2023)
  • Eguchi, H., Yu, Y., Yoshino, Y., Hara H, Tanaka, H., Ikari, A., Plasma-activated medium ameliorates the chemoresistance of human lung adenocarcinoma cells mediated via downregulation of claudin-2 expression. Arch. Biochem. Biophys., 109846 (2023)
  • Ota, A., Kawai, M., Kudo, Y., Segawa, J., Hoshi, M., Kawano, S., Yoshino, Y., Ichihara, K., Shiota, M., Fujimoto, N., Matsunaga, T., Endo, S., Ikari, A., Artepillin C overcomes apalutamide resistance through blocking androgen signaling in prostate cancer cells. Arch. Biochem. Biophys., 735, 109519 (2023)

2022年

  • Shu, S., Kobayashi, M., Marunaka, K., Yoshino, Y., Goto, M., Katsuta, Y., Ikari, A., Magnesium Supplementation Attenuates Ultraviolet-B-Induced Damage Mediated through Elevation of Polyamine Production in Human HaCaT Keratinocytes. Cells., 11, 2268 (2022)
  • Eguchi, H., Kimura, R., Matsunaga, H., Matsunaga, T., Yoshino, Y., Endo, S., Ikari, A., Increase in Anticancer Drug-Induced Toxicity by Fisetin in Lung Adenocarcinoma A549 Spheroid Cells Mediated by the Reduction of Claudin-2 Expression. Int J Mol Sci., 23, 7536 (2022)
  • Sakai, Y., Taguchi, M., Morikawa, Y., Suenami, K., Yanase, E., Takayama, T., Ikari, A., Matsunaga, T., Lowering of brain endothelial cell barrier function by exposure to 4'-iodo-α-pyrrolidinononanophenone. Chem Biol Interact., 364:110052 (2022)
  • Sakai, Y., Morikawa, Y., Nagao, Y., Hattori, J., Suenami, K., Yanase, E., Takayama, T., Ikari, A., Matsunaga, T., 4'-Iodo-α-Pyrrolidinononanophenone Provokes Differentiated SH-SY5Y Cell Apoptosis Through Downregulating Nitric Oxide Production and Bcl-2 Expression. Neurotox Res., doi: 10.1007/s12640-022-00546-y (2022)
  • Kobayashi, M., Yonezawa, A., Takasawa, H., Nagao, Y., Iguchi, K., Endo, S., Ikari, A., Matsunaga, T., Development of cisplatin resistance in breast cancer MCF7 cells by up-regulating aldo-keto reductase 1C3 expression, glutathione synthesis and proteasomal proteolysis. J Biochem., 171:97-108 (2022)
  • Kudo, Y., Endo, S., Fujita, M., Ota, A., Kamatari, Y.O., Tanaka, Y., Ishikawa, T., Ikeda, H., Okada, T., Toyooka, N., Fujimoto, N., Matsunaga, T., Ikari, A., Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer. J. Med. Chem., 65, 4878-4892 (2022)
  • Sakai, Y., Taguchi, M., Morikawa, Y., Miyazono, H., Suenami, K., Ochiai, Y., Yanase, E., Takayama, T., Ikari, A., Matsunaga, T., Apoptotic mechanism in human brain microvascular endothelial cells triggered by 4'-iodo-α-pyrrolidinononanophenone: Contribution of decrease in antioxidant properties. Toxicol. Lett., 355, 127-140 (2022)

2021年

  • Marunaka, K., Shu, S., Kobayashi, M., Goto, M., Katsuta, Y., Yoshino, Y., Ikari, A., Elevation of hyaluronan synthase by magnesium supplementation mediated through the activation of GSK3 and CREB in human keratinocyte-derived HaCaT cells. Int. J. Mol. Sci., 23, 71 (2021)
  • Kobayashi, M., Yonezawa, A., Takasawa, H., Nagao, Y., Iguchi, K., Endo, S., Ikari, A., Matsunaga, T.,
    Development of cisplatin resistance in breast cancer MCF7 cells by up-regulating aldo-keto reductase 1C3 expression, glutathione synthesis, and proteasomal proteolysis. J. Biochem., mvab117 (2021)
  • Yoshino, Y., Marunaka, K., Kobayashi, M., Matsunaga, H., Shu, S., Matsunaga, T., Ikari, A., Protective Effects of Ethanol Extract of Brazilian Green Propolis and Apigenin against Weak Ultraviolet Ray-B-Induced Barrier Dysfunction via Suppressing Nitric Oxide Production and Mislocalization of Claudin-1 in HaCaT Cells. Int. J. Mol. Sci., 22, 10326 (2021)
  • Endo, S., Nishiyama, T., Matuoka, T., Miura, T., Nishinaka, T., Matsunaga, T., Ikari, A.,Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells. Chem. Biol. Interact., 348, 109634 (2021)
  • Hirota, C., Takashina, Y., Yoshino, Y., Hasegawa, H., Okamoto, E., Matsunaga, T., Ikari, A., Reactive Oxygen Species Downregulate Transient Receptor Potential Melastatin 6 Expression Mediated by the Elevation of miR-24-3p in Renal Tubular Epithelial Cells. Cells., 10, 1893 (2021)
  • Kamase, K., Taguchi, M., Ikari, A., Endo, S., Matsunaga, T.,9,10-Phenanthrenequinone provokes dysfunction of brain endothelial barrier through down-regulating expression of claudin-5. Toxicol., 461, 152896 (2021)
  • Ito, A., Nasako, H., Akizuki, R., Takashina, Y., Eguchi, H., Matsunaga, T., Yoshino, Y., Endo, S., Ikari, A.,Elevation of chemosensitivity of lung adenocarcinoma A549 spheroid cells by claudin-2 knockdown through activation of glucose transport and inhibition of Nrf2 signal. Int. J. Mol. Sci., 22, 6582 (2021)
  • Onuma, S., Manabe, A., Yoshino, Y., Matsunaga, T., Asai, T., Ikari, A., Upregulation of chemoresistance by Mg 2+ deficiency through elevation of ATP binding cassette subfamily B member 1 expression in human lung adenocarcinoma A549 cells. Cells., 10, 1179 (2021)
  • Morikawa, Y., Miyazono, H., Kamase, K., Sasajima, Y., Sato, K., Endo, S., Monguchi, Y., Takekoshi, Y., Ikari, A., Matsunaga, T.,Protective effect of aldo-keto reductase 1B1 against neuronal cell damage elicited by 4'-Fluoro-α-pyrrolidinononanophenone. Neurotox Res., 10, 1007 (2021)
  • Endo, S., Kawai, M., Hoshi, M., Segawa, J., Fujita, M., Matsukawa, T., Fujimoto, N., Matsunaga, T., Ikari A., Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells. J Biochem., in press (2021)
  • Eguchi, H., Matsunaga, H., Onuma, S., Yoshino, Y., Matsunaga, T., Ikari, A., Down-regulation of claudin-2 expression by cyanidin-3-glucoside enhances sensitivity to anticancer drugs in the spheroid of human lung adenocarcinoma A549 cells. Int. J. Mol. Sci., 22, 499 (2021)
  • Hirota, C., Takashina, Y., Ikumi, N., Ishizuka, N., Hayashi, H., Tabuchi, Y., Yoshino, Y., Matsunaga, T., Ikari, A., Inverse regulation of claudin-2 and -7 expression by p53 and hepatocyte nuclear factor 4α in colonic MCE301 cells. Tissue Barriers., 9, 1860409 (2021)

2020年

  • Matsunaga, T., Okumura, N., Saito, H., Morikawa, Y., Suenami, K., Hisamatsu, A., Endo, S., Ikari, A., Significance of aldo-keto reductase 1C3 and ATP-binding cassette transporter B1 in gain of irinotecan resistance in colon cancer cells. Chem. Biol. Interact., 332, 109295 (2020)
  • Kobayashi, M., Shu, S., Marunaka, K., Matsunaga, T., Ikari, A., Weak ultraviolet B enhances the mislocalization of claudin-1 mediated by nitric oxide and peroxynitrite production in human keratinocyte-derived HaCaT cells. Int. J. Mol. Sci., 21, 7138 (2020)
  • Endo, S., Oguri, H., Segawa, J., Kawai, M., Hu, D., Xia, S., Okada, T., Irie, K., Fujii, S., Gouda, H., Iguchi, K., Matsukawa, T., Fujimoto, N., Nakayama, T., Toyooka, N., Matsunaga, T. and Ikari, A., Development of novel AKR1C3 inhibitors as new potential treatment for castration-resistant prostate cancer. J. Med. Chem., 63, 10396-10411 (2020)
  • Nasako, H., Takashina, Y., Eguchi, H., Ito, A., Ishikawa, Y., Matsunaga, T., Endo, S., Ikari, A,. Increase in toxicity of anticancer drugs by PMTPV, a claudin-1-binding peptide, mediated via down-regulation of claudin-1 in human lung adenocarcinoma A549 cells. Int. J. Mol. Sci., 21, 5909 (2020)
  • Eguchi, H., Matsunaga, T., Endo, S., Ichihara, K., Ikari, A., Kaempferide enhances chemosensitivity of human lung adenocarcinoma A549 cells mediated by the decrease in phosphorylation of Akt and claudin-2 expression. Nutrients., 12, E1190 (2020)
  • Takashina, Y., Ishizuka, N., Ikumi, N., Hayashi, H., Manabe, A., Hirota, C., Tabuchi, Y., Matsunaga, T., Ikari, A., Upregulation of claudin-7 expression by angiotensin II in colonic epithelial cells of mice fed with NaCl-depleted diets. Int. J. Mol. Sci., 21, E1442 (2020)
  • Nakayama, M., Ishizuka, N., Hempstock, W., Ikari, A. and Hayashi, H., Na+-coupled nutrient cotransport induced luminal negative potential and claudin-15 play an important role in paracellular Na+ recycling in mouse small intestine. Int. J. Mol. Sci., 21, E376 (2020)
  • Endo, S., Morikawa, Y., Kudo, Y., Suenami, K., Matsunaga, T., Ikari, A. and Hara, A., Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids. J. Steroid Biochem. Mol. Biol., 199, 105586 (2020)
  • Nasako, H., Akizuki, R., Takashina, Y., Ishikawa, Y., Shinoda, T., Shirouzu, M., Asai, T., Matsunaga, T., Endo, S. and Ikari, A., Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells. Biochim. Biophys. Acta., 1867, 118642 (2020)

2019年

  • Endo, S., Matsuoka, T., Nishiyama, T., Arai, Y., Kashiwagi, H., Abe, N., Oyama, M., Matsunaga, T. and Ikari, A., Transient decreases in intestinal barrier function by fravonol glycosides from Rosa multiflora. Nutr. Res., 72, 92-104 (2019)
  • Matsunaga, T., Kawabata, S., Yanagihara, Y., Kezuka, C., Kato, M., Morikawa, Y., Endo, S., Chen, H., Iguchi, K., Ikari, A., Pathophysiological roles of autophagy and aldo-keto reductases in development of doxorubicin resistance in gastrointestinal cancer cells. Chem. Biol. Interact., 314, 108839 (2019)
  • Maruhashi R, Eguchi H, Akizuki R, Hamada S, Furuta T, Matsunaga T, Endo S, Ichihara K, Ikari A.,Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells. Sci. Rep., 9, 13753 (2019)
  • Marunaka K, Kobayashi M, Shu S, Matsunaga T, Ikari A.,Brazilian green propolis rescues oxidative stress-induced mislocalization of claudin-1 in human keratinocyte-derived HaCaT cells. Int J Mol Sci., 20, pii: E3869 (2019)
  • Marunaka K, Fujii N, Kimura T, Furuta T, Hasegawa H, Matsunaga T, Endo S,Ikari A.,Rescue of tight junctional localization of a claudin-16 mutant D97S byantimalarial medicine primaquine in Madin-Darby canine kidney cells.Sci. Rep., 9, 9647 (2019)
  • Endo, S., Uchibori, M., Suyama, M., Arai, Y., Hu, D., Xia, S., Ma, B., Kabir, A., Kamatari, O.Y., Kuwata, K., Toyooka, N., Matsunaga T. and Ikari, A., Novel Atg4B inhibitors potentiate cisplatin therapy in lung cancer cells through blockade of autophagy. Comput. Toxicol., 12, 100095 (2019)
  • Endo, S., Miyagi, N., Matsunaga T. and Ikari, A., Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity. Chem. Biol. Interact., 305, 12-20 (2019)
  • Takashina, Y., Manabe, A., Tabuchi, Y. and Ikari, A., Cyanidin Increases the Expression of Mg2+ Transport Carriers Mediated by the Activation of PPARα in Colonic Epithelial MCE301 Cells. Nutrients, 11, E641 (2019)
  • Akizuki, R., Eguchi, H., Endo, S., Matsunaga, T. and Ikari A., ZO-2 suppresses cell migration mediated by a reduction in matrix metalloproteinase 2 in claudin-18-expressing lung adenocarcinoma A549 cells. Biol. Pharm. Bull, 42, 247-254 (2019)
  • Matsunaga, T., Tsuchimura, S., Azuma, N., Endo, S., Ichihara, K., Ikari, A., Caffeic acid phenethyl ester potentiates gastric cancer cell sensitivity to doxorubicin and cisplatin by decreasing proteasome function. Anticancer Drugs, 30, 251-259 (2019)
  • Manabe, A., Furukawa, C., Hasegawa, H., Matsunaga, T., Endo, S., Ikari, A., Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells.J. Cell. Physiol., 234, 8951-8962 (2019)

2018年

  • Morikawa, Y., Shibata, A., Sasajima, Y., Suenami, K., Sato, K., Takekoshi, Y., Endo, S., Ikari, A., Matsunaga, T., Sibutramine facilitates apoptosis and contraction of aortic smooth muscle cells through elevating production of reactive oxygen species., Eur. J. Pharmacol., 841, 113-121 (2018)
  • Fujii, T., Shimizu, T., Yamamoto, S., Funayama, K., Fujita, K., Tabuchi, Y., Ikari, A., Takeshima, H., Sakai, H., Crosstalk between Na(+),K(+)-ATPase and a volume-regulated anion channel in membrane microdomains of human cancer cells. Biochim. Biophys. Acta, 1864, 3792-3804 (2018)
  • Ishizuka, N., Nakayama, M., Watanabe, M., Tajima, H., Yamauchi, Y., Ikari, A., Hayashi, H., Luminal Na(+) homeostasis has an important role in intestinal peptide absorption in vivo.Am. J. Physiol. Gastrointest. Liver Physiol., 315, G799-G809 (2018)
  • Shimizu, T., Takayanagi, K., Iwashita, T., Ikari, A., Anzai, N., Okazaki, S., Hara, H., Hatano, M., Sano, T., Ogawa, T., Kanozawa, K., Hasegawa, H., Down-regulation of magnesium transporting molecule, claudin-16, as a possible cause of hypermagnesiuria with the development of tubulo-interstitial nephropathy. Magnes. Res., 31, 11-23 (2018)
  • Eguchi, H., Akizuki, R., Maruhashi, R., Tsukimoto, M., Furuta, T., Matsunaga, T., Endo, S. and Ikari, A., Increase in resistance to anticancer drugs involves occludin in spheroid culture model of human lung adenocarcinoma A549 cells. Sci. Rep., 8, 15157 (2018)
  • Takashina, Y., Manabe, A., Hasegawa, H., Matsunaga, T., Endo, S. and Ikari, A., Sodium citrate increases expression and flux of Mg2+ transport carriers mediated by activation of MEK/ERK/c-Fos pathway in renal tubular epithelial cells. Nutrients, 10, E1345 (2018)
  • Sonoki H, Tanimae A, Furuta T, Endo S, Matsunaga T, Ichihara K and Ikari A., Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells. J. Nutr. Biochem., 56, 205-214 (2018)
  • Akizuki R, Maruhashi R, Eguchi H, Kitabatake K, Tsukimoto M, Furuta T, Matsunaga T, Endo S and Ikari A., Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells. Biochem. Biophys. Acta., 1865, 769-780 (2018)
  • Endo, S., Hoshi, M., Matsunaga, T., Inoue, T., Ichihara, K. and Ikari, A., Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis. Biochem. Biophys. Res. Commun., 497, 437-443 (2018)
  • Maruhashi, R., Akizuki, R., Sato, T., Matsunaga, T., Endo, S., Yamaguchi, M., Yamazaki, Y., Sakai, H. and Ikari, A. Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models. Biochim. Biophys. Acta, 1865, 470-479 (2018)
  • Matsunaga, T., Kamase, K., Takasawa, H., Yamaji, Y., Endo, S., El-Kabbani, O., Ikari, A., Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1. Chem. Biol. Interact., 279, 10-20 (2017)

2017年

  • Endo, S., Xia, S., Suyama, M., Morikawa, Y., Oguri, H., Hu, D., Ao, Y., Takahara, S., Horino, Y., Hayakawa, Y., Watanabe, Y., Gouda, H., Hara, A., Kuwata, K., Toyooka, N., Matsunaga, T. and Ikari, A., Synthesis of potent and selective inhibitors of aldo-keto reductase 1B10 and their efficacy against proliferation, metastasis and cisplatin resistance of lung cancer cells, J. Med. Chem., 60, 8441-8455 (2017)
  • Furukawa, C., Ishizuka, N., Hayashi, H., Fujii, N., Manabe, A., Tabuchi, Y., Matsunaga, T., Endo, S. and Ikari, A., Up-regulation of claudin-2 expression by aldosterone in colonic epithelial cells of mice fed with NaCl-depleted diets. Sci. Rep., 7, 12223 (2017)
  • Matsunaga, T., Morikawa, Y., Kamase, K., Horinouchi, M., Sasajima, Y., Suenami, K., Sato, K., Takekoshi, Y., Endo, S., El-Kabbani, O. and Ikari, O., Enhancement of Endothelial Barrier Permeability by Mitragynine, Biol. Pharm. Bull., 40, 1779-1783 (2017)
  • Manabe, A., Furukawa, C., Endo, S., Marunaka, K., Nishiyama, T., Fujii, N., Tabuchi, Y., Matsunaga, T. and Ikari, A., Chlorpheniramine increases paracellular permeability to marker fluorescein lucifer yellow mediated by internalization of occludin in murine colonic epithelial cells, Biol. Pharm. Bull., 40, 1299-1305 (2017)
  • Marunaka, K., Furukawa, C., Fujii, N., Kimura, T., Furuta, T., Matsunaga, T., Endo, S.,
  • Hasegawa, H., Anzai, N., Yamazaki, Y., Yamaguchi, M. and Ikari A., The RING Finger- and PDZ Domain-Containing Protein PDZRN3 Controls Localization of the Mg2+ Regulator Claudin-16 in Renal Tube Epithelial Cells., J. Biol. Chem., 292, 13034-13044 (2017)
  • Sonoki, H., Tanimae, A., Endo, S., Matsunaga, T., Furuta, T., Ichihara, K. and Ikari, A., Kaempherol and chrysin decrease claudin-2 expression mediated by inhibition of STAT3 in lung adenocarcinoma A549 cells, Nutrients, 9, E597 (2017)
  • Matsunaga, T., Morikawa, Y., Kamata, K., Shibata, A., Miyazono, H., Sasajima, Y., Suenami, K., Sato, K., Takekoshi, Y., Endo, S., El-Kabbani, O. and Ikari, A., α-Pyrrolidinononanophenone provokes apoptosis of neuronal cells through alterations in antioxidant properties, Toxicology, 386, 93-102 (2017)
  • Matsunaga, T., Morikawa, Y., Tanigawa, M., Kamata, K., Shibata, A., Sasajima, Y., Suenami, K., Sato, K., Takekoshi ,Y., Endo, S., El-Kabbani, O. and Ikari, A., Structure-activity relationship for toxicity of α-pyrrolidinooctanophenone derivatives to endothelial cells, Forensic Toxicol., 35, 309-316 (2017)
  • Endo, S., Takada, S., Honda, R.P., Müller, K., Weishaupt, J.H., Andersend, P.M., Ludolph, A.C., Kamatari, Y.O., Matsunaga, T., Kuwata, K., El-Kabbani, O. and Ikari, A., Instability of C154Y variant of aldo-keto reductase 1C3, Chem. Biol. Interact., 276, 194-202 (2017)
  • Furukawa, C., Fujii, N., Manabe, A., Matsunaga, T., Endo, S., Hasegawa, H., Ito, Y., Yamaguchi, M., Yamazaki, Y. and Ikari, A., Up-regulation of transient receptor potential melastatin 6 channel expression by tumor necrosis factor-a in the presence of epidermal growth factor receptor tyrosine kinase inhibitor. J. Cell. Physiol., 232, 2841-2850 (2017)
  • Hichino, A., Okamoto, M., Taga, S., Akizuki, R., Endo, S., Matsunaga, T. and Ikari, A., Down-regulation of claudin-2 expression and proliferation by epigenetic inhibitors in human lung adenocarcinoma A549 cells, J. Biol. Chem., 292, 2411-2421. (2017)
  • Akizuki, R., Shimobaba, S., Matsunaga, T., Endo, S. and Ikari, A., Claudin-5, -7, and -18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma. Biochim. Biophys. Acta., 1864, 293-302 (2017)
  • Morikawa, Y., Shibata, A., Okumura, N., Ikari, A., Sasajima, Y., Suenami, K., Sato, K., Takekoshi, Y., El-Kabbani, O. and Matsunaga, T., Sibutramine provokes apoptosis of aortic endothelial cells through altered production of reactive oxygen and nitrogen species. Toxicol. Appl. Pharmacol., 314, 1-11 (2017)

2016年

  • Sugatani J, Noguchi Y, Hattori Y, Yamaguchi M, Yamazaki Y, Ikari A., Threonine-408 Regulates the Stability of Human Pregnane X Receptor through Its Phosphorylation and the CHIP/Chaperone-Autophagy Pathway. Drug Metab. Dispos., 44, 137-50 (2016)
  • Fujii, N., Matsuo, Y., Matsunaga, T., Endo, S., Sakai, H., Yamaguchi, M., Yamazaki, Y., Sugatani, J. and Ikari, A., Hypotonic stress-induced down-regulation of claudin-1 and -2 mediated by dephosphorylation and clathrin-dependent endocytosis in renal tubular epithelial cells. J. Biol. Chem., 291, 24787-24799 (2016)
  • Matsunaga, T., Saito, H., Endo, S., Iguchi, K., Soda, M., El-Kabbani, O., Hara, A. and Ikari, A., Roles of aldo-keto reductase 1B10 and 1C3 and ATP-binding cassette transporter in docetaxel tolerance. Free Radic. Res., 50, 1296-1308 (2016)
  • Matsunaga, T., Suzuki, A., Kezuka, C., Okumura, N., Iguchi, K., Inoue, I., Soda, M., Endo, S., El-Kabbani, O., Hara, A. and Ikari, A., Aldo-keto reductase 1B10 promotes development of cisplatin resistance in gastrointestinal cancer cells through down-regulating peroxisome proliferator-activated receptor-g-dependent mechanism. Chem. Biol. Interact., 256, 142-153 (2016)
  • Endo, S., Miyagi, N., Matsunaga, T., Hara, A. and Ikari, A. Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase. Biochem. Biophys. Res. Commun., 472, 231-236 (2016)
  • Shimobaba, S., Taga, S., Akizuki, R., Endo, S., Matsunaga, T., Watanabe, R., Yamaguchi, M., Yamazaki, Y., Sugatani, J. and Ikari, A. Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 in human lung adenocarcinoma A549 cells. Biochim. Biophys. Acta., 1863, 1170-1178 (2016)

2015年

  • Ikari, A., Taga, S., Watanabe, R., Sato, T., Shimobaba, S., Sonoki, H., Endo, S., Matsunaga, T., Sakai, H., Yamaguchi, M., Yamazaki, Y. and Sugatani, J. Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells. Biochim. Biophys. Acta., 1848, 2326-2336 (2015)
  • Matsunaga T, Kezuka C, Morikawa Y, Suzuki A, Endo S, Iguchi K, Miura T, Nishinaka T, Terada T, El-kabbani O, Hara A, Ikari A. Up-regulation of carbonyl reductase 1 renders development of doxorubicin resistance in human gastrointestinal cancers. Biol. Pharm. Bull., 13, 7487-7499 (2015)
  • Hu, D., Miyagi, N., Arai, Y., Oguri, H., Miura, T., Nishinaka, T., Terada, T., Gouda, H., El-Kabbani, O., Xia, S., Toyooka, N., Hara, A., Matsunaga, T., Ikari, A. and Endo, S., Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1. Org. Biomol. Chem., 13, 7487-7499 (2015)
  • Endo, S., Noda, M., Ikari, A., Tatematsu, K., El-Kabbani, O., Hara, A., Kitade, Y. and Matsunaga, T., Characterization of hamster NAD+-dependent 3(17)β-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily. J. Biochem., 158, 425-434. (2015)
  • Yamazaki Y, Yasui K, Hashizume T, Suto A, Mori A, Murata Y, Yamaguchi M, Ikari A, Sugatani J. Involvement of a cyclic AMP-dependent signal in the diet-induced canalicular trafficking of ATP-binding cassette transporter g5/g8. Hepatology, 62,1215-26 (2015)
  • Sonoki H, Sato T, Endo S, Matsunaga T, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A. Quercetin decreases claudin-2 expression mediated by up-regulation of microRNA miR-16 in lung adenocarcinoma A549 cells. Nutrients, 7, 4578-4592 (2015)
  • Ikari, A., Fujii, N., Hahakabe, S., Hayashi, H., Yamaguchi, M., Yamazaki, Y., Endo, S., Matsunaga, T. and Sugatani, J. Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKCβ-Dependent GATA-2 in MDCK Cells. J. Cell. Physiol., 230, 2776-2787 (2015)
  • Morikawa, Y., Kezuka, C., Endo, S., Ikari, A., Soda, M., Yamamura, K., Toyooka, N., El-Kabbani, O., Hara, A. and Matsunaga, T. Acquisition of doxorubicin resistance facilitates migrating and invasive potentials of gastric cancer MKN45 cells through up-regulating aldo-keto reductase 1B10, Chem. Biol. Interact., 250, 30-39 (2015)
  • Yamaguchi, M., Matsui, M., Higa, R., Yamazaki, Y., Ikari, A., Miyake, M., Miwa, M., Ishii, S., Sugatani, J. and Shimizu T.., A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation, Biochem. Pharmacol., 93, 482-495 (2015)
  • Endo, S., Matsunaga, T., Ikari, A., El-Kabbani, O., Hara A and Kitade, Y., Phenylalanine 217 of rabbit aldo-keto reductase (AKR1C33) is a determinant for its strict NADP(H)-specificity and high sensitivity to a mixed-type inhibitor deoxycorticosterone, Arch. Biochem. Biophys., 569, 19-25 (2015)
  • Takayanagi, K., Shimizu, T., Tayama, Y., Ikari, A., Anzai, N., Iwashita, T., Asakura, J., Hayashi, K., Mitarai, T. and Hasegawa, H., Down-regulation of transient receptor potential (TRP) M6 channel as a cause of hypermagnesiuric hypomagnesemia in obese type-2 diabetic rats, Am. J. Physiol. Renal. Physiol., 308, 1386-1397 (2015)
  • Arai, Y., Endo, S., Miyagi, N., Abe, N., Miura, T., Nishinaka, T., Terada, T., Oyama, M., Goda, H., El-Kabbani, O., Hara, A., Matsunaga, T. and Ikari, A., Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1), Fitoterapia,101, 51-56 (2015)
  • Endo, S., Nishiyama, A., Suyama, M., Takemura, M., Soda, M., Huayue, C., Tajima, K., El-Kabbani, O., Bunai, Y., Hara, A., Matsunaga, T. and Ikari, A., Protective roles of aldo-keto reductase 1B10 and autophagy against toxicity induced by p-quinone metabolites of tert-butylhydroquinone in lung cancer A549 cells, Chem. Biol. Interact., 234, 282-289 (2015)

2014年

  • Endo, S., Arai, Y., Matsunaga, T., Ikari, A., El-Kabbani, O., Hara, A. and Kitade, Y., AKR1C30 and AKR1C31 with Site-Directed Mutagenesis: Identifying the Roles of Residues 54 and 56 in the Binding of Substrates and Inhibitors, Biol. Pharm. Bull., 37, 1848-1852 (2014)
  • Matsunaga, T., Yamaji, Y., Tomokuni, T., Morita, H., Morikawa, Y., Suzuki, A., Yonezawa, A., Endo, S., Ikari, A., Iguchi, K., El-Kabbani, O., Tajima, K. and Hara, A., Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome, Free Radic. Res., 48, 1371-1385 (2014)
  • Endo, S., Hu, D., Matsunaga, T., Otsuji, Y., El-Kabbani, O., Kandeel, M., Ikari, A., Hara, A., Kitade, Y. and Toyooka, N., Synthesis of non-prenyl analogues of baccharin as selective and potent inhibitors for aldo-keto reductase 1C3, Bioorg. Med. Chem., 22, 5220-5233 (2014)
  • Sugatani, J., Hattori, Y., Noguchi, Y., Yamaguchi, M., Yamazaki, Y. and Ikari, A., Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1., Drug Metab. Dispos., 42, 1708-1718 (2014)
  • Ikari, A., Watanabe, R., Sato, T., Taga, S., Shimobaba, S., Yamaguchi, M., Yamazaki, Y., Endo, S., Matsunaga, T and Sugatani, J., Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cells, Biochim. Biophys. Acta, 1843, 2079-2088 (2014)
  • Matsunaga, T., Morikawa, Y., Haga, M., Endo, S., Soda, M., Yamamura K., El-Kabbani, O., Tajima, K., Ikari, A. and Hara, A., Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10, Toxicol. Appl. Pharmacol., 278, 180-189 (2014)
  • Matsunaga, T., Yamaguchi, A., Morikawa, Y., Kezuka, C., Takazawa, H., Endo, S., El-Kabbani, O., Tajima, K., Ikari, A. and Hara, A., Induction of aldo-keto reductases (AKR1C1 and AKR1C3) abolishes the efficacy of daunorubicin chemotherapy for leukemic U937 cells, Anticancer Drugs, 25, 868-877 (2014)
  • Ikari, A., Tonegawa, C., Sanada, A., Kimura, T., Sakai, H., Hayashi, H., Hasegawa, H., Yamaguchi, M., Yamazaki, Y., Endo, S., Matsunaga, T. and Sugatani, J., Tight Junctional Localization of Claudin-16 is Regulated by Syntaxin 8 in Renal Tubular Epithelial Cells, J. Biol. Chem., 289, 13112-13123 (2014)
  • Endo, S., Matsunaga, T., Arai, Y., Ikari, A., Tajima, K., El-Kabbani, O., Yamano, S., Bunai, Y., Hara, A. and Kitade, Y., Cloning and characterization of four rabbit aldo-keto reductases featuring broad substrate specificity for xenobiotic and endogenous carbonyl compounds: Their relationship with multiple forms of drug ketone reductases, Drug Metab. Dispos., 42, 803-812 (2014)
  • Sugatani, J., Sadamitsu, S., Yamaguchi, M., Yamazaki, Y., Higa, R., Hattori, Y., Uchida, T., Ikari, A., Sugiyama, W., Watanabe, T., Ishii, S., Miwa, M. and Shimizu, T., Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age, FASEB J., 28, 440-452 (2014)
  • Takahashi, Y., Fujii, T., Fujita, K., Shimizu, T., Higuchi, T., Tabuchi, Y., Sakamoto, H., Naito, I., Manabe, K., Uchida, S., Sasaki, S., Ikari, A., Tsukada, K. and Sakai, H., Functional coupling of chloride-proton exchanger ClC-5 to gastric H+,K+-ATPase, Biol. Open, 15, 12-21 (2014)

2013年

  • Yamazaki, Y., Yasuda, K., Matsuyama, T., Ishihara, T., Higa, R., Sawairi, T., Yamaguchi, M., Egi, M., Akai, S., Miyase, T., Ikari, A., Miwa, M. and Sugatani, J., A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice, Biochem. Pharmacol., 86, 632-644 (2013)
  • Ikari, A., Atomi, K., Yamazaki, Y., Sakai, H., Hayashi, H., Yamaguchi, M. and Sugatani, J., Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation, Biochim. Biophys, Acta., 1833, 2617-2627 (2013)
  • Endo, S., Hu, D., Suyama, M., Matsunaga, T., Sugimoto, K., Matsuya, Y., El-Kabbani, O., Kuwata, K., Hara, A., Kitade, Y. and Toyooka, N., Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10, Bioorg. Med. Chem., 21, 6378-6384 (2013)
  • Endo, S., Matsunaga, T., Matsumoto, A., Arai, Y., Ohno, S., El-Kabbani, O., Tajima, K., Bunai, Y., Yamano, S., Hara, A. and Kitade, Y., Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D2, and other endogenous and xenobiotic carbonyl compounds, Biochem. Pharmacol., 86, 1366-1375 (2013)
  • Endo, S., Arai, Y., Hara, A., Kitade, Y., Bunai, Y., El-Kabbani, O. and Matsunaga T., Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenase, Biol. Pharm. Bull., 36, 1514-1518 (2013)
  • Endo, S., Matsunaga, T., Fujimoto, A., Kumada, S., Arai, Y., Miura, Y., Mikamo, H., El-Kabbani, O., Yamano, S., Iinuma, M. and Hara, A., Characterization of a rabbit morphine 6-dehydrogenase and its two isoforms which function as NAD+-dependent 3α(17β)-hydroxysteroid dehydrogenases, Arch. Biochem. Biophys., 529, 131-139 (2013)
  • Endo, S., Fujimoto, A., Kumada, S., Matsunaga, T., Ohno, S., Mano, J., Tajima, K., El-Kabbani, O. and Akira Hara, Modulation of activity and inhibitor sensitivity of rabbit aldose reductase-like protein by oxidized glutathione and SH-reagents, Chem. Biol. Interact., 202, 146-152 (2013)
  • Matsunaga, T., Hojo, A., Yamane, Y., Endo, S., El-Kabbani, O. and Hara, A., Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers, Chem. Biol. Interact., 202, 234-242 (2013)

2012年

  • Ikari, A., Sato, T., Watanabe, R., Yamazaki, Y. and Sugatani, J., Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells, Biochim. Biophys, Acta., 1823, 1110-1118 (2012)
  • Ikari, A., Atomi, K., Takiguchi, A., Yamazaki, Y., Hayashi, H., Hirakawa, J. and Sugatani, J., Enhancement of cell-cell contact by claudin-4 in renal epithelial Madin-Darby canine kidney cells, J. Cell. Biochem., 113, 499-507 (2012)
  • Sugatani, J., Uchida, T., Kurosawa, M., Yamaguchi, M., Yamazaki, Y., Ikari, A. and Miwa, M., Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by post-translational modification of PXR protein, Drug Metab. Dispos., 40, 2031-2040 (2012)
  • Sugatani, J., Sadamitsu, S., Wada, T., Yamazaki, Y., Ikari, A. and Miwa, M., Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet, Nutr. Metabol., 9, 23 (2012)
  • Soda, M., Endo, S., Matsunaga, T., Zhao, H. T., El-Kabbani, O., Iinuma, M., Yamamura, K. and Hara, A., Inhibition of Human Aldose Reductase-like Protein (AKR1B10) by α- and γ-Mangostins, Major Components of Pericarps of Mangosteen, Biol. Pharm. Bull., 35, 2075-2080. (2012)
  • Endo, S., Matsunaga, T., Kumada, S., Fujimoto, A., Ohno, S., El-Kabbani, O., Hu, D., Toyooka, N., Mano, J., Tajima, K. and Hara, A., Characterization of rabbit aldose reductase-like protein with 3beta-hydroxysteroid dehydrogenase activity, Arch. Biochem. Biophys., 527, 23-30. (2012)
  • Matsunaga, T., Hosogai, M., Arakaki, M., Endo, S., El-Kabbani, O. and Hara, A., 9,10-Phenanthrenequinone Induces Monocytic Differentiation of U937 Cells through Regulating Expression of Aldo-Keto Reductase 1C3, Biol. Pharm. Bull., 35, 1598-1602. (2012)
  • Matsunaga, T., Endo, S., Takemura, M., Soda, M., Yamamura, K., Tajima, K., Miura, T., Terada, T., El-Kabbani, O. and Hara, A., Reduction of Cytotoxic p-Quinone Metabolites of tert-Butylhydroquinone by Human Aldo-keto Reductase (AKR) 1B10, Drug Metab. Pharmacokinet., 27, 553-558. (2012)
  • Osman, W., Endo, S., Oh-Hashi, K., Kitamura, Y. and Kitade, Y., Molecular characterization and mutational analysis of recombinant diadenosine 5′,5"-P(1),P(4)-tetraphosphate hydrolase from Plasmodium falciparum, Biol. Pharm. Bull., 35, 1191-1196. (2012)
  • Endo, S., Matsunaga, T., Kanamori, A., Otsuji, Y., Nagai, H., Sundaram, K., El-Kabbani, O., Toyooka, N., Ohta, S. and Hara, A., Selective inhibition of human type-5 17beta-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis, J. Nat. Prod., 75, 716-721. (2012)
  • Sundaram, K., Endo, S., Matsunaga, T., Tanaka, N., Hara, A. and El-Kabbani, O., Structure of the His269Arg mutant of the rat aldose reductase-like protein AKR1B14 complexed with NADPH, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 68, 400-403. (2012)
  • Matsunaga, T., Haga, M., Watanabe, G., Shinoda, Y., Endo, S., Kajiwara, Y., Tanaka, H., Inagaki, N., El-Kabbani, O. and Hara, A., 9,10-Phenanthrenequinone promotes secretion of pulmonary aldo-keto reductases with surfactant, Cell Tissue Res., 347, 407-417. (2012)
  • Soda, M., Hu, D., Endo, S., Takemura, M., Li, J., Wada, R., Ifuku, S., Zhao, H. T., El-Kabbani, O., Ohta, S., Yamamura, K., Toyooka, N., Hara, A. and Matsunaga, T., Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10, Eur. J. Med. Chem., 48, 321-329. (2012)
  • Minehira, D., Takeda, D., Urata, H., Kato, A., Adachi, I., Wang, X., Matsuya, Y., Sugimoto, K., Takemura, M., Endo, S., Matsunaga, T., Hara, A., Koseki, J., Narukawa, K., Hirono, S. and Toyooka, N., Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-beta-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1, Bioorg. Med. Chem., 20, 356-367. (2012)

2011年

  • Ikari, A., Sanada, A., Sawada, H., Okude, C., Tonegawa, C. and Sugatani, J., Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells, Biochim. Biophys. Acta., 1808, 1502-1508 (2011)
  • Ikari, A., Takiguchi, A., Atomi, K., Sato, T. and Sugatani, J., Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby canine kidney cells, J. Cell. Physiol., 226, 1471-1478 (2011)
  • Ikari, A., Takiguchi, A., Atomi, K. and Sugatani, J., Epidermal growth factor increases clathrin-dependent endocytosis and degradation of claudin-2 protein in MDCK II cells, J. Cell. Physiol., 226, 2448-2456 (2011)
  • Ikari, A., Sato, T., Takiguchi, A., Atomi, K., Yamazaki, Y. and Sugatani, J., Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cells, Life Sci., 88, 628-633 (2011)
  • Ikari, A., Sawada, H., Sanada, A., Tonegawa, C., Yamazaki, Y. and Sugatani, J., Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21Cip1 and p27Kip1 in renal epithelial NRK-52E cells, J. Cell. Biochem., 112, 3563-3572 (2011)
  • Yamazaki, Y., Hashizume, T., Morioka, H., Sadamitsu, S., Ikari, A., Miwa, M. and Sugatani, J., Diet-induced lipid accumulation in liver enhances ATP-binding cassette transporter g5/g8 expression in bile canaliculi, Drug Metab. Pharmacokinet., 26, 442-450 (2011)
  • Matsunaga, T., Shinoda, Y., Inoue, Y., Shimizu, Y., Haga, M., Endo, S., El-Kabbani, O. and Hara, A., Aldo-keto reductase 1C15 as a quinone reductase in rat endothelial cell: its involvement in redox cycling of 9,10-phenanthrenequinone, Free Radic. Res., 45, 848-857. (2011)
  • Endo, S., Matsunaga, T., Fujita, A., Kuragano, T., Soda, M., Sundaram, K., Dhagat, U., Tajima, K., El-Kabbani, O. and Hara, A., Activation of aldo-keto reductase family member 1B14 (AKR1B14) by bile acids: Activation mechanism and bile acid-binding site, Biochimie, 93, 1476-1486. (2011)
  • Takemura, M., Endo, S., Matsunaga, T., Soda, M., Zhao, H. T., El-Kabbani, O., Tajima, K., Iinuma, M. and Hara, A., Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid, J. Nat. Prod., 74, 1201-1206. (2011)
  • El-Kabbani, O., Dhagat, U., Soda, M., Endo, S., Matsunaga, T. and Hara, A., Probing the inhibitor selectivity pocket of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis, Bioorg. Med. Chem. Lett., 21, 2564-2567. (2011)
  • Matsunaga, T., Yamane, Y., Iida, K., Endo, S., Banno, Y., El-Kabbani, O. and Hara, A., Involvement of the aldo-keto reductase, AKR1B10, in mitomycin-c resistance through reactive oxygen species-dependent mechanisms, Anticancer Drugs, 22, 402-408. (2011)
  • Matsunaga, T., Shinoda, Y., Inoue, Y., Endo, S., El-Kabbani, O. and Hara, A., Protective effect of rat aldo-keto reductase (AKR1C15) on endothelial cell damage elicited by 4-hydroxy-2-nonenal, Chem. Biol. Interact., 191, 364-370. (2011)
  • Endo, S., Matsunaga, T., Ohta, C., Soda, M., Kanamori, A., Kitade, Y., Ohno, S., Tajima, K., El-Kabbani, O. and Hara, A., Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol, Chem. Biol. Interact., 191, 261-268. (2011)
  • Tabuchi, M., Seo, M., Inoue, T., Ikeda, T., Kogure, A., Inoue, I., Katayama, S., Matsunaga, T., Hara, A. and Komoda, T., Anal. Chem., 83, 1131-1136 (2011)

2010年

  • Sugatani, J., Sadamitsu, S., Kurosawa, M., Ikushiro, S., Sakaki, T., Ikari, A. and Miwa, M., Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats, Drug Metab. Dispos., 38, 1655-1664 (2010)
  • Ikari, A., Sanada, A., Okude, C., Sawada, H., Yamazaki, Y., Sugatani, J. and Miwa, M., Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells, J. Cell. Physiol., 222, 481-487 (2010)
  • Ikari, A., Kinjo, K., Atomi, K., Sasaki, Y., Yamazaki, Y. and Sugatani, J., Extracellular Mg2+ regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylation, Biochim. Biophys. Acta., 1798, 415-421 (2010)
  • Ikari, A., Atomi, K., Kinjo, K., Sasaki, Y. and Sugatani, J., Magnesium deprivation inhibits a MEK-ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells, Life Sci., 86, 766-773 (2010)
  • Sugatani, J., Osabe, M., Kurosawa, M., Kitamura, N., Ikari, A. and Miwa, M., Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: cell cycle-dependent expression, Drug Metab. Dispos., 38, 177-186 (2010)
  • Endo, S., Matsunaga, T., Fujita, A., Tajima, K., El-Kabbani, O. and Hara, A., Rat aldose reductase-like protein (AKR1B14) efficiently reduces the lipid peroxidation product 4-oxo-2-nonenal, Biol. Pharm. Bull., 33, 1886-1890. (2010)
  • El-Kabbani, O., Scammells, P. J., Day, T., Dhagat, U., Endo, S., Matsunaga, T., Soda, M. and Hara, A., Structure-based optimization and biological evaluation of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors, Eur. J. Med. Chem., 45, 5309-5317. (2010)
  • Endo, S., Matsunaga, T., Kuragano, T., Ohno, S., Kitade, Y., Tajima, K., El-Kabbani, O. and Hara, A., Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10), Arch. Biochem. Biophys., 503, 230-237. (2010)
  • Dhagat, U., Endo, S. (#Equal first author contribution), Soda, M., Hara, A. and El-Kabbani, O., Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme, Bioorg. Med. Chem. Lett., 20, 5274-5276. (2010)
  • Asada, Y., Kuroishi, C., Ukita, Y., Sumii, R., Endo, S., Matsunaga, T., Hara, A. and Kunishima, N., Dimeric crystal structure of rabbit L-gulonate 3-dehydrogenase/lambda-crystallin: insights into the catalytic mechanism, J. Mol. Biol., 401, 906-920. (2010)
  • Zhao, H. T., Soda, M., Endo, S., Hara, A. and El-Kabbani, O., Selectivity determinants of inhibitor binding to the tumour marker human aldose reductase-like protein (AKR1B10) discovered from molecular docking and database screening, Eur. J. Med. Chem., 45, 4354-4357. (2010)
  • Endo, S., Matsunaga, T., Soda, M., Tajima, K., Zhao, H. T., El-Kabbani, O. and Hara, A., Selective inhibition of the tumor marker AKR1B10 by antiinflammatory N-phenylanthranilic acids and glycyrrhetic acid, Biol. Pharm. Bull., 33, 886-890. (2010)
  • Endo, S., Matsunaga, T., Kuwata, K., Zhao, H. T., El-Kabbani, O., Kitade, Y. and Hara, A., Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10, Bioorg. Med. Chem., 18, 2485-2490. (2010)
  • Matsunaga, T., Arakaki, M., Kamiya, T., Haga, M., Endo, S., El-Kabbani, O. and Hara, A., Nitric oxide mitigates apoptosis in human endothelial cells induced by 9,10-phenanthrenequinone: role of proteasomal function, Toxicology, 268, 191-197. (2010)
  • Matsunaga, T., Tsuji, Y., Kaai, K., Kohno, S., Hirayama, R., Alpers, D., Komoda, T. and Hara, A., Cancer Chemother. Pharmacol., 66, 517-526 (2010)
  • Ikeda, T., Seo M., Inoue I., Katayama, S., Matsunaga, T., Hara, A. Komoda, T. and Tabuchi M., Anal. Chem., 82, 1128-1132 (2010)
  • Dhagat, U., Endo, S. (#Equal first author contribution), Mamiya, H., Hara, A. and El-Kabbani, O., Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme, Acta Crystallogr. D Biol. Crystallogr., 66, 198-204. (2010)