Field of Study

Clinical Pharmacy

Keywords

Clinical Pharmacy, Pharmaceutical care, Pharmacoepidemiology, Pharmacotherapy, Therapeutic drug monitoring

Lab URL

https://www.gifu-pu.ac.jp/lab/renkei/

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  特任教授　宇佐美 英績 Research Professor Usami Eiseki Ph.D.

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  教授（兼務）　吉村 知哲 Professor Yoshimura Tomoaki Ph.D. yoshimurat

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  教授（兼務）　北市 清幸 Professor Kitaichi Kiyoyuki Ph.D. kitaichi

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  准教授（兼務）　野口 義紘 Associate Professor Noguchi Yoshihiro Ph.D. noguchiy

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  講師（兼務）　種田 靖久 Associate Professor Oida Yasuhisa Ph.D. oida-ya

研究テーマ Research Subjects

　医療連携薬学研究室は、大垣市民病院との連携研究室であり、大垣市民病院薬剤部の薬剤師と共同で研究を行います。医療現場では、チーム医療の一員として様々な場面で薬剤師も医療に関わり、特に、安全・安心な薬物療法に貢献しています。しかし、医療現場では、さまざまな問題や疑問が生じます。そこで、臨床疑問（クリニカルクエスチョン）を研究課題として研究疑問（リサーチクエスチョン）に落とし込んで疑問を解決する研究を進めています。

　特に、医薬品の適正使用推進のために電子カルテの詳細な患者データおよび医療ビッグデータ（レセプトデータ、大規模副作用自発報告データベースなどのリアルワールドデータ）を活用して新たなエビデンスの構築を目指しています。また、薬物動態学的解析による薬物治療最適化に関する研究として、薬物血中濃度と薬効や有害事象との関連を検討して個々の患者に最適な薬物治療の提供を検討しています。

　The Laboratory of Medical Collaborative Pharmacy is a laboratory in partnership with Ogaki Municipal Hospital, and conducts research in association with pharmacists from the Department of Pharmacy of the Ogaki Municipal Hospital. Pharmacists play an important role in medical care settings, and in particular, help provide safe and secure drug therapy. The medical fraternity routinely encounters various problems and questions related to medical care. Therefore, we plan to investigate clinically important problems (clinical questions) by treating them as research questions.
In particular, we aim to generate new evidence through analysis of detailed patient data from electronic medical records and medical big data (real-world data such as medicine receipt data and large-scale spontaneous adverse drug reaction reporting databases) to promote the appropriate use of drugs. In addition, through our research on drug treatment optimization through pharmacokinetic analysis, we are examining the relationship between concentration of drug in the blood, its efficacy and occurrence of adverse events. This will enable the administration of optimal drug treatment for individual patients.

研究課題 Research Objectives

1. 病院薬剤師の業務に関連した課題の解決に関する研究
   Research on solving problems related to the work of clinical pharmacists
2. 薬剤疫学的手法による医療ビッグデータの解析と臨床への活用
   Analysis of medical big data by pharmacoepidemiologic approach and its practical use
3. 薬物血中濃度測定による医薬品の有効性・安全性に関する研究
   Research on efficacy and safety of drugs by measuring drug blood levels

最近の研究成果 Research Results

1. Noguchi Y, Asano H, Masuda R, Teshigawara Y, Go M, Kimura M, Usami E, Yoshimura T. Relationship between Anaplastic Lymphoma Kinase (ALK) Inhibitors and Epileptic Seizure Disorder: A Post-Marketing Surveillance Study. Oncology. 2024. doi: 10.1159/000539426.
2. Go M, Kimura M, Yamada S, Usami E, Noguchi Y, Yoshimura T. Comparison of Safety and Treatment Continuity of Palbociclib and Abemaciclib for Hormone Receptor-Positive, HER2-Negative Metastatic/Recurrent Breast Cancer. J Pharm Pract. 2024: 8971900241247653. doi: 10.1177/08971900241247653.
3. Go M, Noguchi Y, Masuda R, Asano H, Kimura M, Usami E, Yoshimura T. Association between CDK4/6 inhibitors and drug-related osteonecrosis of the jaw: A pharmacoepidemiological study using the FDA Adverse Events Reporting System. Int J Cancer. 2024. doi: 10.1002/ijc.34962.

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