• 教授 中村 光浩 Professor Nakamura Mitsuhiro Ph. D. mnakamura

研究テーマ Research Subjects


 この目的を達成するために、下記の Dry 研究および Wet 研究を行っている。
② LC-MS を利用した生体マトリックス中薬物濃度の高感度分析法およびその臨床応用

Our mission is to create a new "knowledge" for the proper use of pharmaceutical products through the basic and/or clinical research. We develop the collected data into information through evaluation and analysis.

From the "information", we find the universal "knowledge", which is useful in medicine, and transmit it to the world. We produce quality graduates/researchers who have a comprehensive, panoramic view in the data management process. We perform both of dry and wet research toward our goal as listed below.
1 . Research of regulatory science and translational research.
2 . Development and application of a new LC-MS method for drug molecules and/or metabolites in biological matrices.
3 . Discovery and validation of new disease biomarker, using lipidomics analysis.


研究課題 Research Objectives

  1. 医療情報データベースを用いたドラッグリポジショニング
    Drug repositioning research using real-world data and real-world evidence
  2. 有害事象自発報告ビッグデータを用いた医薬品適正使用に係る解析
    Evaluation of adverse event profile using a spontaneous reporting system
  3. リピドミクスによる新規白血病バイオマーカーの探索と臨床応用
    Lipidomics analysis for leukemia using LC-MS
  4. リピドミクスによる新規アトピー性皮膚炎バイオマーカーの探索と検証
    Lipidomics analysis for atopic dermatitis using LC-MS
  5. マイクロドーズ手法の TDM への応用
    Development of micro-dosing technique for therapeutic drug monitoring

最近の研究成果 Research Results

  1. Nakao S, Hasegawa S, Umetsu R, Shimada K, Mukai R, Tanaka M, Matsumoto K, Yoshida Y, Inoue M, Satake R, Nishibata Y, Liao J, Nakamura M. Pharmacovigilance study of anti-infective-related acute kidney injury using the Japanese Adverse Drug Event Report database. BMC Pharmacology and Toxicology, 2021. 22. 47.
  2. Tanaka M, Matsumoto K, Satake R, Yoshida Y, Inoue M, Hasegawa S, Suzuki T, Iwata M, Iguchi K, Nakamura M. Gentamicin-induced hearing loss: a retrospective study using the Food and Drug Administration Adverse Event Reporting System and a toxicological study using drug-gene network analysis. HELIYON, 2021. 7, e07429.
  3. Satake R, Matsumoto K, Tanaka M, Mukai R, Shimada K, Yoshida Y, Inoue M, Hasegawa S, Iguchi K, Ikesue H, Shimizu S, Nishida S, Suzuki A, Hashida T, Nakamura M. Analysis of drug-induced gastrointestinal obstruction and perforation using the Japanese Adverse Drug Event Report database. Frontiers in Pharmacology, 2021. 12. 692292.
  4. Fujimori M, Hasegawa S, Sasaoka S, Iguchi K, Nakamura M. A study of the association between seasonal influenza vaccines and the increased risk of Guillain-Barré syndrome using Vaccine Adverse Event Reporting System, 2018-2019. Die Pharmazie, 2021.76, 437-443.
  5. Inoue M, Matsumoto K, Tanaka M, Yoshida Y, Satake R, Goto F, Shimada K, Mukai R, Hasegawa S, Suzuki T, Ikesue H, Liao J, Hashida T, Nakamura M. Analysis of chemotherapy-induced peripheral neuropathy using the Japanese Adverse Drug Event Report database. Scientific Reports, 2021. 11, 11324.