At the Laboratory of Pharmaceutical Electron Transfer Chemistry, we aim to elucidate the electron transfer mechanisms of pharmaceuticals by integrating both electrochemical and computational approaches. Our research focuses on understanding how pharmaceuticals can control diseases at the molecular level and on uncovering the reaction mechanisms involved in biological processes and diseases. This is based on the idea that a wide range of physiological phenomena--from disease onset to pharmacological action--are energetically regulated by electron transfer associated with chemical reactions of biomolecules.
In addition, we are working on the development of electrochemically driven pharmaceutical manufacturing methods and modular production systems. Through the understanding and control of electron transfer mechanisms in pharmaceuticals, we aim to contribute to society.
研究課題 Research Objectives
薬物、天然物、および生体材料に対するスーパーオキシドの反応性に関する機構的研究 Mechanistic study on the reactivity of superoxide toward drugs, natural products, and biomaterials
プロトン電子共役移動反応の遷移状態理論とトンネル効果に関する電気化学的研究 Electrochemical study of transition state and tunnel effect via proton-coupled electron transfer
生体内低分解性の抗ウイルス薬の開発に関する研究 Study on the development of hypodegradable antiviral drugs in vivo
電気化学反応を利用したオンサイト型過酸化水素製造モジュールの開発 Development of an On-site Hydrogen Peroxide Production Module Driven by Electrochemistry
ポリフェノールのプロトン電子共役移動反応による Superoxide 消去に関する研究 Study of the superoxide elimination by polyphenols through proton-coupled electron transfer.
最近の研究成果 Research Results
Nakayama T., Effect of the phenyl substituent on two-proton-coupled electron transfer between hydroquinone and superoxide radical anion, Electrochemistry, 93, 6, p. 067001, (2025).
Nakayama, T., Uno B., Electronic inductive and resonance effects of substituents on concerted two-proton-coupled electron transfer between electrogenerated superoxide and hydroquinone derivatives in N,N-dimethylformamide, Chemical Engineering Journal, 491, 152201, (2024)
Nakayama, T., Reactivity of acetaminophen toward the superoxide radical anion electrogenerated in N,N-dimethylformamide, Journal of Electroanalytical Chemistry, 978, 118892, (2024)
Nakayama, T., Uno B., Concerted two-proton-coupled electron transfer from piceatannol to electrogenerated superoxide in N,N-dimethylformamid, ACS Omega, 9, 23, 24889-24898, (2024).
Nakayama, T., Electrochemical and digital simulation analyses of two-proton-coupled electron transfer between superoxide and hydroquinone: mechanistic insights and kinetic parameters, Chemistry Select, 9, 36,(2024).
