高分子を創る・視る・操る技術を活かした、次世代医療材料の開発を目指す。 Aiming to develop next-generation medical materials by utilizing its technologies for synthesizing, evaluating, and manipulating functional polymers.
The Laboratory of Pharmaceutical Physical Chemistry conducts applied pharmaceutical research from the perspectives of physical chemistry and polymer chemistry, focusing on the following areas:
1. Development of solid-state polymerization technology platform for the creation of innovative functional materials through the utilization of natural polymers, and its application to drug delivery system (DDS)
We are promoting the development of innovative scientific and technological approaches that utilize natural polymers produced by plants, animals, and bacteria in nature. Using solid-state polymerization technology rooted in green chemistry, we control molecular weight while simultaneously employing the free radicals generated during the process as initiators for the solid-state polymerization of functional monomers, thereby imparting novel functional polymer chains to the natural polymers.
2. Development of Stimulus-Responsive Functional Polymers and Their Application to DDS
We are developing functional polymers whose physical properties and higher-order structures change in response to external stimuli such as the pH of cancerous tissues, light, or heat, and are expanding our research into DDS using nanoparticle carriers to aid in cancer treatment. Pancreatic cancer, known as the solid tumor with the lowest survival rate, inhibits the delivery of anticancer drugs and nanoparticles to pancreatic cancer cells due to increased desmoplasia (fibrous stroma). Therefore, i) polymer-enzyme conjugates that degrade extracellular matrix components, and ii) DDS capable of penetrating the tumor stroma for new pancreatic cancer treatments, incorporating anticancer drugs to eliminate tumor stromal cells, are addressed.
3. Creation of New Functional Devices via Thin-Film Treatment Using Atmospheric Pressure Plasma and Application to Biocomponent Control Technology Using Plasma-Treated Water
We are developing methods for precise control of the adhesion of proteins and cells to plasma-treated devices, and are investigating the effects of plasma-treated water on promoting seed germination by controlling protein and enzyme expression levels in cells.
研究課題 Research Objectives
高分子化学を基盤とするがん治療に資する DDS の開発 Development of DDS for tumor therapy based on polymer chemistry
環境負荷低減型固相重合法の窮理 The Principles of Environmentally Friendly Solid-state Polymerization
外部刺激応答性を有する高次な機能性高分子材料の開発 Development of a highly functionalized polymer responsive to external stimuli
プラズマ技術を基盤とする機能性バイオマテリアル表面の創成 Development of functional biomaterial surface based on plasma technique
新たな膵がん治療に向けたがん間質を突破する高分子医薬の創出 Development of macromolecular drugs aiming to break through the pancreatic cancer stroma
最近の研究成果 Research Results
Naoki Doi, Yukinori Yamauchi, Yasushi Sasai, Ryosuke Nagai, Madoka Ikawa, Masayuki Kuzuya, Shin-ichi Kondo, Characterization of Mechanochemical Solid-State Polymerization for Development of Sulfobetaine Polymer-Drug Conjugates: Design and Synthesis of Artemisinin-Conjugated Novel Methacrylamide Derivatives, Chemical and Pharmaceutical Bulletin, 74(3), 260-268 (2026)
Naoki Doi, Yukinori Yamauchi, Yasushi Sasai, Tsukasa Ide, Hiroya Ishizuka, Taiyo Inagaki, Miyu Sato, Masayuki Kuzuya, Shin-ichi Kondo, Amphiphilic sulfobetaine copolymer for boosting internalization into cancer cells: Synthesis by green innovative solid-state copolymerization and characterization, Macromolecules, 58(22), 12163-12180 (2025)
Naoki Doi, Yukinori Yamauchi, Yasushi Sasai, Kaho Suzuki, Masayuki Kuzuya, Shin-ichi Kondo, Dextran-based nanoparticles with 5-FU-conjugated polymethacrylate segments for drug delivery: Synthesis of amphiphilic graft copolymers by mechanochemical solid-state polymerization and characterization, International Journal of Biological Macromolecules, 132950 (2024)
Naoki Doi, Yukinori Yamauchi, Yasushi Sasai, Naohiro Yuda, Masayuki Kuzuya, Shin-ichi Kondo, Characterization of well-defined PHEMA-based bottlebrushes with controlled chain length and grafting density, Journal of Polymer Science, 62(7), 1310-1322 (2024)
Naoki Doi, Kazuichi Araki, Yoichiro Fukuta, Yudai Kuwagaito, Yukinori Yamauchi, Yasushi Sasai, Shin-ichi Kondo, Masayuki Kuzuya, Anti-glycation and antioxidant effects of Chaga mushroom decoction extracted with a fermentation medium, Food Science and Technology Research, 29(2), 155-161 (2023)
