高分子を創る・視る・操る技術を活かした、次世代医療材料の開発を目指す。 Aiming to develop next-generation medical materials by utilizing its technologies for synthesizing, evaluating, and manipulating functional polymers.
We have worked on the fundamentals and applications of chemical reactions, chemical structure and characteristics of various materials, such as polymer material, in the view of pharmaceutical science. The following research fields are our primary research focus.
1 . Surface modification of polymer material and its bio-application. We have been developing original materials for medical use by the surface modification of polymer. The durable surface wettability on the hydrophobic polymer surface, on which carboxylic groups were introduced, was fabricated by plasma treatment, and then other functional groups or polymer graft chains were introduced on its surface. The polymer surface fabricated by this way is used for the immobilization of enzyme or antibody maintaining their high activity, and it is also suitable for the cell culture.
2 . Development of stimuli-responsive polymer and its application to DDS. Stimuli-responsive polymers as a nanocarrier are specialized nano-sized active delivery vehicles that evolve with an external signal, such as heat, pH, light and so on, and are equipped with load-and-release modalities within their constituting units. We have been investigating the development of stimuli-responsive polymer and its application to DDS.
3 . Development of macromolecular drugs to break through the pancreatic cancer stroma. Pancreatic cancer stroma prevents the delivery of anticancer drugs and DDS carrier into the pancreatic cancer cells. We have challenged the fabrication of polymer conjugates possessing extracellular matrix proteases to increase the stability of the proteases and to provide targeting ability for them, and developed the anticancer-loaded macromolecules for apoptosis-inducing of pancreatic cancer cells.
研究課題 Research Objectives
プラズマを利用した高分子基材表面へのリン脂質自己組織化膜の構築とその応用 Fabrication of self-assembled phospholipid layer onto the polymer surface by plasma-assisted method and its bio-application
固体プラズマ化学の基礎と高分子の自己組織化を利用した DDS 開発 Fundamentals of solid-state plasma chemistry and application to DDS by self-assembling of polymer
DDS への応用を目指した高次の機能性高分子開発 Development of highly functionalized polymer for DDS
プラズマ技術を基盤とする機能性バイオマテリアル表面の創成 Development of functional biomaterial surface based on plasma technique
新たな膵癌治療に向けたがん間質を突破する高分子医薬の創出 Development of macromolecular drugs aiming to break through the pancreatic cancer stroma
最近の研究成果 Research Results
Kondo S., Doi N., Sasai Y., Yamauchi Y., Kuzuya M., Characterization of Shape of Polymer Nano-Films Possessing Various Crosslinking Chain Length, J. Photopolym. Sci. Technol., 34, 533-536 (2021)
Yasuda M., Ikeoka M., Kondo S., Skin-related enzyme inhibitory activity by hydrolyzable polyphenols in water chestnut (Trapa natans) husk, Bioscience, Biotechnology, and Biochemistry, 85, 666-674 (2021)
Kondo S., Sasai Y., Doi N., Yamauchi Y., Kuzuya M., Characterization of pH-Responsible Polymer Nano-Film Synthesized on Self-Assembled Phospholipid Layer Fabricated by Plasma-Assisted Method, J. Photopolym. Sci. Technol., 33, 333-336 (2020)
Doi N., Yamauchi Y., Ikegami R., Kuzuya M., Sasai Y., Kondo S., Photo-responsive Polymer Micelles from o-Nitrobenzyl Ester-Based Amphiphilic Block Copolymers Synthesized by Mechanochemical Solid-State Copolymerization, Polym. J., 52, 1375-1385 (2020)
Kondo S., Sasai Y., Doi N., Yamauchi Y., Kuzuya M., Application to Nano Drug Carrier Using Polymer NanoFilm Synthesized on Self-Assembled Phospholipid Layer Fabricated by Plasma-Assisted Method , J. Photopolym. Sci. Technol., 32, 541-544 (2019)
