Since pharmaceutical sciences consist of a broad range of academic disciplines, a wide variety of instruments are absolutely imperative to achieve meaty education and research. However, all of the instruments possess own durable life and period of guarantee and the time-varying deterioration is an unavoidable problem. Therefore, the maintenance, management and update of instruments at an appropriate interval are crucially important. The Research Instruments Center is in charge of the management of chiefly large-size research instruments by the cooperation of highly professional faculty members and facility staffs in our university. Because there is a definite ceiling to maintain over-budgeted instruments for a single-department school in pharmaceutical sciences, the Research Instruments Center carves the number of instruments down to the minimum necessary. In the last 10 years, a cooperative framework between Gifu University and Gifu Pharmaceutical University is vigorously building to reduce overlap in research instruments via the mutual exploitation of both instruments. While it can take a certain level of adjustment to establish an attractive way because each university has different faculties, the Research Instruments Center plans to create a mutually beneficial system.
Our research activity focuses on the molecular control of disease applicable as pharmaceuticals with the scientific view of chemistry and informatics. These approaches are based on the following idea that various vital activities, including disease onset and pharmacology are energetically controlled by electron transfer induced by chemical reactions. Practically, we adopt some methods and theories, quantum theoretical chemistry, electrochemistry, and analytical chemistry, to clarify the mechanism of living phenomenon as electron transfer and energy conversion associated with the chemical reaction.
研究課題 Research Objectives
薬物、天然物、および生体材料に対するスーパーオキシドの反応性に関する機構的研究 Mechanistic study on the reactivity of superoxide toward drugs, natural products, and biomaterials
プロトン電子共役移動反応の遷移状態理論とトンネル効果に関する電気化学的研究 Electrochemical study of transition state and tunnel effect via proton-coupled electron transfer
生体内低分解性の抗ウイルス薬の開発に関する研究 Study on the development of hypodegradable antiviral drugs in vivo
分子鋳型高分子を用いた酸化触媒の開発に関する研究 Study of oxidation catalyst using molecular imprinted polymers
ポリフェノールのプロトン電子共役移動反応による Superoxide 消去に関する研究 Study of the superoxide elimination by polyphenols through proton-coupled electron transfer.
最近の研究成果 Research Results
Nakayama T., Honda R., Kuwata K., Usui S., Uno B., Electrochemical and Mechanistic Study of Reactivities of α-, β-, γ-, and δ-Tocopherol toward Electrogenerated Superoxide in N,N-Dimethylformamide through Proton-Coupled Electron Transfer, Antioxidants, 11(1), 9 (2022).
Nakayama T., Honda R., Kuwata K., Usui S., Uno B., Electrochemical and Mechanistic Study of Superoxide Scavenging by Pyrogallol in N,N-Dimethylformamide through Proton-Coupled Electron Transfer, Electrochem, 3, 1, 115-128 (2022).
Nakayama, T., Honda, R., Electrochemical and mechanistic study of oxidative degradation of favipiravir by electrogenerated superoxide through proton-coupled electron transfer, ACS Omega, 6, 33, 21730-21740 (2021).
Nakayama, T., Honda, R., Electrochemical and mechanistic study of superoxide elimination by mesalazine through proton-coupled electron transfer, Pharmaceuticals, 14(2), 120 (2021).
Nakayama, T., Okumura, N., and Uno, B., Complementary effect of intra- and intermolecular hydrogen bonds on electron transfer in b-hydroxy-anthraquinone derivatives, J. Phys. Chem.B, 124(5), 848-860 (2020).
