In our laboratory, we focus on the following research projects.
1 . The research to optimize the drug prescription for each patient based on pharmacokinetics analysis in collaboration with hospitals and other clinical facilities. Our combined analysis of pharmacokinetics using therapeutic drug monitoring by HPLC and LC-MS/MS could be applicable to investigate the relationship between these pharmacokinetic factors and clinical outcome during drug therapy.
2 . The research related to new psychoactive substrates (NPSs) in collaboration with several research facilities and local government, we try to establish the systems to monitor and identify NPSs and their metabolites in order to prevent their illegal use. We also plan to find out the mechanisms of actions of NPSs.
3 . The research to investigate the pharmacokinetic properties and the safety of drugs and functional food ingredients in collaboration with several companies. We investigate the pharmacokinetic properties, the drug-food interaction and the mechanisms of drug delivery system, and assess the controlled-release of drugs using novel materials in order to promote the appropriate use of drugs and to develop new functional foods.
研究課題 Research Objectives
各種薬物測定系の確立と能動的な薬物治療への関与を目指した基礎および臨床の統合的研究 To establish the systems of therapeutic drug monitoring and its application in clinical in order for clinical pharmacists to be positively involved in pharmacological therapy
危険ドラッグおよびその代謝物の検出 / 同定と作用メカニズムに関する研究 To establish the methods for monitoring and identifying NPSs and their metabolites and to elucidate their mechanisms of actions
薬剤および健康食品素材の生体内挙動と安全性評価に関する研究 To investigate the pharmacokinetic properties and the safety of drugs and functional food ingredients
最近の研究成果 Research Results
Nakatochi M, ... Kitaichi K., ... Ozaki N. (51 authors). Copy number variations in RNF216 and postsynaptic membrane-associated genes are associated with bipolar disorder: a case-control study in the Japanese population. Psychiatry Clin Neurosci., 79, 12-20 (2025).
Nakano T., Oida Y., Morimoto S., Muranishi K., Ushio S., Yamashina T., Uchiyama M., Mishima K., Kitaichi K., Nakamura Y., Matsuo K. Case report of pharmacokinetic analysis of continuous intravenous infusion of fentanyl in a patient with severe burn: burn shock stage complicates pain management. J Pharmaceu Health Care Sci., 10, 41 (2024).
Ohi K., Shimada M., Soda M., Nishizawa D., Fujikane D., Takai K., Kuramitsu A., Muto Y., Sugiyama S., Hasegawa J., Kitaichi K., Ikeda K., Shioiri T. Genome-wide DNA methylation risk scores for schizophrenia derived from blood and brain tissues further explain the genetic risk in patients stratified by polygenic risk scores for schizophrenia and bipolar disorder. BMJ Mental Health, 27, e300936 (2024).
Ariga M., Hagita J., Soda M., Oida Y., Teramachi H., Kitaichi K. Daily dose of metformin caused acute kidney injury with lactic acidosis: A case report. J Med Case Rep., 17, 393 (2023).
Tachi R., Ohi K., Nishizawa D., Soda M., Fujikane D., Hasegawa J., Kuramitsu A, Takai K., Muto Y., Sugiyama S., Kitaichi K., Hashimoto R., Ikeda K., Shioiri T. Mitochondrial Genetic Variants Associated with Bipolar Disorder and Schizophrenia in a Japanese Population. Int J Bipolar Disord., 11, 26 (2023).
