The purpose of our research is to develop new effective medicine for neurodegenerative diseases. They are amyotrophic lateral sclerosis disease (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD). Our research is focused primarily on idiopathic basal ganglia calcification (IBGC) that is traditionally called as'Fahr's disease (FD)'. We have been investigating neurodegenerative diseases from genomic studies, functional studies using iPS cells and qualitative research data based on personal interviews. In addition, we have been working on neurodegenerative diseases from the viewpoints of the regeneration and development of the nervous system. To achieve our goals, we promote domestic and international joint research and industry-academia collaboration across disciplines, and actively incorporate and utilize the latest technologies such as iPS cells, genome analysis and editing, imaging, and AI.
研究課題 Research Objectives
認知症、パーキンソン病、筋萎縮性側索硬化症（ALS）などの神経変性疾患に共通した発症機序解明と再生・創薬研究 The clarification of the pathophysiological mechanism and the development of new agents for neurodegenerative diseases such AD, PD and ALS based on the aspect of the neuronal death
特発性大脳基底核石灰化症（IBGC) の病態解明と治療薬開発 The research of the pathophysiology, the accurate diagnostic methods and the therapeutic strategies on idiopathic basal ganglia calcification (IBGC) which is also traditionally called 'Fahr's disease (FD)'
胎生期から生涯における環境要因によるエピジェネティクス撹乱の神経機能に及ぼす影響の解明 Elucidation of the effects of epigenetic disturbances caused by environmental factors on neural functions.
最近の研究成果 Research Results
Go, S., Kurita, H., Hatano, M., Matsumoto, K., Nogawa, H., Fujimura, M., Inden, M., Hozumi, I., DNA methyltransferase- and histone deacetylase-mediated epigenetic alterations induced by low-level methylmercury exposure disrupt neuronal development, Arch Toxicol, 95, 1227-1239 (2021).
Ito, T., Inden, M., Ueda, T., Asaka, Y., Kurita, H., Hozumi, I., The neuroprotective effects of activated a7 nicotinic acetylcholine receptor against mutant copper-zinc superoxide dismutase 1-mediated toxicity. Sci Rep, 10, 22157 (2020).
Takase, N., Inden, M., Hirai, S., Yamada, Y., Kurita, H., Takeda, M., Yamaguchi, E., Itoh, A., Hozumi, I., The Novel gem-Dihydroperoxide 12AC3O Suppresses High Phosphate-Induced Calcification via Antioxidant Effects in p53LMAco1 Smooth Muscle Cells, Int J Mol Sci, 21, 4628 (2020).
Kurita, H., Yabe, S., Ueda, T., Inden, M., Kakita, A., Hozumi, I.. MicroRNA-5572 Is a Novel MicroRNA-Regulating SLC30A3 in Sporadic Amyotrophic Lateral Sclerosis, Int J Mol Sci, 21, 4482 (2020).
Sekine, S.I., Kaneko, M., Tanaka, M., Ninomiya, Y., Kurita ,H., Inden, M., Yamada, M., Hayashi, Y., Inuzuka, T., Mitsui, J., Ishiura, H., Iwata, A., Fujigasaki, H., Tamaki, H., Tamaki, R., Kito, S., Taguchi, Y., Tanaka, K., Atsuta, N., Sobue, G., Kondo, T., Inoue, H., Tsuji, S., Hozumi, I., Functional evaluation of PDGFB-variants in idiopathic basal ganglia calcification, using patient-derived iPS cells, Sci Rep, 9, 5698 (2019)
