The purpose of our research is to develop new effective medicine for neurodegenerative diseases. They are amyotrophic lateral sclerosis disease (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD). Our research is focused primarily on primary brain calcification (PBC) that is traditionally called as'Fahr's disease (FD)'. We have been investigating neurodegenerative diseases from genomic studies, functional studies using iPS cells and qualitative research data based on personal interviews. In addition, we have been working on neurodegenerative diseases from the viewpoints of the regeneration and development of the nervous system. To achieve our goals, we promote domestic and international joint research and industry-academia collaboration across disciplines, and actively incorporate and utilize the latest technologies such as iPS cells, genome analysis and editing, imaging, and AI.
研究課題 Research Objectives
認知症、パーキンソン病、筋萎縮性側索硬化症（ALS）などの神経変性疾患に共通した発症機序解明と再生・創薬研究 The clarification of the pathophysiological mechanism and the development of new agents for neurodegenerative diseases such AD, PD and ALS based on the aspect of the neuronal death
特発性基底核石灰化症（PBC) の病態解明と治療薬開発 The research of the pathophysiology, the accurate diagnostic methods and the therapeutic strategies on primary brain calcification (PBC) which is also traditionally called 'Fahr's disease (FD)'
胎生期から生涯における環境要因によるエピジェネティクス撹乱の神経機能に及ぼす影響の解明 Elucidation of the effects of epigenetic disturbances caused by environmental factors on neural functions.
最近の研究成果 Research Results
Ito T, Ohuchi K, Kurita H, Oida Y, Murakami T, Takizawa S, Fujimaki A, Murata J, Hozumi I, Kitaichi K, Inden M. Neuroprotective effects of activated fibroblast growth factor receptor 1 via the suppression of p53 accumulation against poly-PR-mediated toxicity. Biochem Biophys Res Commun 743: 151181 (2025).
Sakamoto S, Riku Y, Teiko K Nomura, Kimura A, Yamahara N, Ohuchi K, Yoshida M, Iwasaki Y, Shimohata T, Inden M, Honda R. Ultrasensitive detection of TDP-43 and Amyloid-β protein aggregates using micelle-assisted seed amplification assay. Transl Neurodegener,13(1):51 (2024).
Fujimaki A., Ohuchi K., Takizawa S., Murakami T., Kurita H., Hozumi I., Wen X., Kitamura Y., Wu Z., Maekawa Y., Inden M., The neuroprotective effects of FG-4592, a hypoxia-inducible factor prolyl-hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells. Sci Rep, 13, 15629 (2023).
Ueda T., Ito T., Inden M., Kurita H., Yamamoto A., Hozumi I., Stem cells from human exfoliated deciduous teeth-conditioned medium (SHED-CM) is a promising treatment for amyotrophic lateral sclerosis. Front Pharmacol, 13, 805379 (2022).
Kawai K., Hirayama T., Imai H., Murakami T., Inden M., Hozumi I., Nagasawa H., Molecular imaging of labile heme in living cells using a small molecule fluorescent probe. J Am Chem Soc, 144, 3793-3803 (2022).
