"Chemoprospecting" is a core project in our laboratory aimed at discovering novel natural products that have the potential to become drug candidates and health enhancers. To this end, we select specific plants by considering modern phylogenetic classifications and the occurrence of the plant secondary metabolites. Gifu is rich in wild plants, allowing us access to a wide variety of plant resources. Recently, our staff and students discovered unique ceanothane-type triterpenes from the Japanese raisin tree, unusual zapotin-type flavones from white sapote, and rare norlignan-derived naphthophenones from palm grass. At the same time, our collaborators evaluate various bioactivities such as anticancer and anti-inflammatory properties. For example, drimane-type sesquiterpenes found in water pepper, an ingredient in Gifu's local cuisine, showed significant anti-inflammatory activity. We hope these findings will contribute academically to achieving the SDGs in our local community. Additionally, we conduct educational activities on herbal medicines and functional foods derived from plant materials.
研究課題 Research Objectives
有用植物の探索と化学系統分類に関する研究 Phylogeny-based chemoprospecting research of the vascular plants
植物二次代謝産物の分離と構造解析に関する研究 Isolation and elucidation of plant secondary metabolites
岐阜地域の植物資源の応用と保全に関する研究 Sustainable development of domestic plant resources in Gifu region
メタボロミクスを用いた生薬製剤および植物試料の多成分分析 Multicomponent analysis of plant materials using MS- and NMR-based metabolomics
最近の研究成果 Research Publications
Haba M., Oyama M. Study on isolation of standard compounds applicable to tests for crude drugs in the Japanese pharmacopoeia. Pharm. Med. Device Regul. Sci., 55(2), 157-162 (2024).
Kamiya T., Mizuno N., Hayashi K., Otsuka T., Haba M., Abe N., Oyama M., Hara H. Methoxylated flavones from Casimiroa edulis La Llave suppress MMP9 expression via inhibition of the JAK/STAT3 pathway and TNFα-dependent pathway. J. Agric. Food Chem., 72(26), 14678-14683 (2024).
Nakashima K., Abe N., Oyama M., Murata H., Inoue M. Sulfur-containing spiroketals from Breynia disticha and evaluations of their anti-inflammatory effect. Beilstein J. Org. Chem., 19, 1604-1614 (2023).
Jalmakhanbetova R.I., Suleimen Y.M., Abe N., Oyama M., Metwaly A.M., Eissa I.H., Ishumuratova M.Y., Ibatayev A.A. Isolation and in silico SARS-CoV-2 main protease inhibition potential of chrysoeriol from Chondrilla brevirostris Fisch. & C. A. Mey. Bull. Karaganda Univ., Chem. Ser., (1), 78-85 (2022).
Haba M., Abe N., Kamiya T., Mizuno N., Okubo S., Yamaura T., Hara H., Oyama M. Two new methoxylated flavones isolated from Casimiroa edulis La Llave and their MMP-9 inhibitory activity. Nat. Prod. Res., DOI: 10.1080/14786419.2022.2048300 (2022).
