Field of Study
Allergy, Immunopharmacology, Functional foods
Food allergy, hypersensitivity, atopic dermatitis, herbal medicines
  • 教授 田中 宏幸 Professor Tanaka Hiroyuki Ph.D. hirotnk

研究テーマ Research Subjects




The goal of our laboratory is to elucidate the pathogenic mechanism of allergies and to develop therapeutic agents. Allergy is a chronic condition involving an abnormal reaction to an ordinarily harmless substance called an allergen. What causes this over-reaction? Why are allergic diseases increasing in recent years? What kind of mechanism causes symptoms to occur due to abnormal immune response? There are still so many points to be clarified.

Therefore, we will try to establish a pathological model of allergic diseases using cells and animals, search for therapeutic targets by clarifying the cells and molecules involved in the pathogenesis of these chronic inflammatory diseases, and develop a therapeutic strategy.

Now, by conducting joint research with allergy specialists and pharmaceutical companies, we are searching for seeds of new therapeutic agents for allergic diseases and materials for functional foods.

研究課題 Research Objectives

  1. 医薬品等の含有成分によるアレルギー発症防止のための評価手法開発に関する研究(日本医療研究開発機構 分担研究)                               Research on the development of evaluation methods for preventing the onset of allergic reaction caused by ingredients in pharmaceuticals and other products
  2. 抗アレルギー活性を有する植物エキスによる機能性食品の開発(企業との共同研究)
    Development of functional foods using plant extracts with anti-allergic activity
  3. 食物アレルギーの根治を目指すペプチド療法の開発研究(企業との共同研究)
    Development research of peptide therapy aiming at curative therapy of food allergies

最近の研究成果 Research Results

  1. Yamashita H, Shigemori A, Murata M, Tanaka H, Inagaki N, Tsutsui M, Kimura M. Impact of orallyadministered oligosaccharides in a murine model of food allergy. J Funct Foods. 85, 104646 (2021).
  2. Takayama S., Kawanishi M., Yamauchi K., Tokumitsu D., Kojima H., Masutani T., Iddamalgoda A., Mitsunaga T., Tanaka H. Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes. J Nat Med. 75, 623-232 (2021).
  3. Yamada H., Kobayashi R., Shimizu S., Yamada Y., Ishida M., Shimoda H., Kato-Hayashi Hm Fujii H, Iihara H, Tanaka H, Suzuki A, Implementation of a standarised pharmacist check of medical orders prior to preparation of anticancer drugs to reduce drug wastage. Int J Clin Prac 74, e13464 (2020).
  4. Matsui T, Yamashita H, Saneyasu KI, Tanaka H, Ito K, Inagaki N. Vitamin D deficiency exacerbates sensitization and allergic diarrhea in a murine food allergy model. Allergol Int. 67, 89-291 (2018).
  5. Yagami A., Aihara M., Ikezawa Z., Hide M., Kishikawa R., Morita E., Chinuki Y., Fukutomi Y., Urisu A., Fukushima A., Itagaki Y., Sugiura S., Tanaka H., Teshima R., Kato Z., Noguchi E., Nakamura M., Saito H., Matsunaga K., Outbreak of immediate-type hydrolyzed wheat protein allergy due to a facial soap in Japan. J Allergy Clin Immunol, 140, 879-881.e7 (2017).