Taisei Ito, Kazuki Ohuchi, Hisaka Kurita, Takanori Murakami, Shinnosuke Takizawa, Ayaka Fujimaki, Junya Murata, Yasuhisa Oida, Isao Hozumi, Kiyoyuki Kitaichi, Masatoshi Inden. Activated fibroblast growth factor receptor 1 mitigated poly-PR-induced oxidative stress and protein translational impairment. Biol Pharm Bull. 2025;48:93-100.

Taisei Ito, Kazuki Ohuchi, Hisaka Kurita, Takanori Murakami, Shinnosuke Takizawa, Ayaka Fujimaki, Junya Murata, Yasuhisa Oida, Isao Hozumi, Kiyoyuki Kitaichi, Masatoshi Inden. Neuroprotective effects of activated fibroblast growth factor receptor 1 via the suppression of p53 accumulation against poly-PR-mediated toxicity. Biochem Biophys Res Commun. 2025;743:151181.

Mizuki Tsuru, Taisei Ito, Kazuki Komai, Fukuto Kunitomo, Yukie Nakayamaa, Takanori Murakami, Kazuki Ohuchi, Yasuhiro Shinkai, Tomoki Kimura, Nobuhiko Miura, Yoshito Kumagai, Isao Hozumi, Masatoshi Inden, Hisaka Kurita. Hypoxia-inducible factor prolyl hydroxylase inhibitor, FG4592, induces endogenous metallothionein3 expression in human neuronal cell line, ReNcell CX cells. Biol Pharm Bull. 2025;48:137-143.

Hisaka Kurita, Kazuki Ohuchi, Masatoshi Inden. Effects of Environmental Non-Essential Toxic Heavy Metals on Epigenetics During Development. Toxics. 2025;13:167. Review.

Kazuki Ohuchi, Ku Watanabe, Mutsuko Izutsu, Ayane Mishima, Junya Murata, Hisaka Kurita, Isao Hozumi, Yuichi Hayashi and Masatoshi Inden. Type III sodium-dependent inorganic phosphate transporters are required for the phenotypes in human brain microvascular endothelial cells. Exp Cell Res. 2025;448:114556.

Isao Hozumi, Hisaka Kurita, Fuminori Hyodo, Kazuhiro Ozawa, Yasuteru Inoue, Megumi Yamada, Yuichi Hayashi, Takayoshi Shimohata, Masayuki Matsuo, Kazuki Ohuchi, Masatoshi Inden. A patient with a MYORG variant in primary brain calcification shows rapid clinical course and increased volume of calcification in an image analyzer. Clin Neurol Neurosurg. 2025;254:108954.

Hisaka Kurita, Hiroki Kitaura, Kazuya Nishii, Tomohiko Masaka, Kazuki Ohuchi, Masatoshi Inden, Akiyoshi Kakita, Masatake Osawa, Isao Hozumi. Generation of a new Slc20a2 knockout mouse line as in vivo model for primary brain calcification. Mol Brain. In press.

Ayane Nakano, Shogo Maekawa, Takanori Murakami, Ayaka Fujimaki, Shinnosuke Takizawa, Junya Murata, Kazuki Ohuchi, Hisaka Kurita, Kazuyuki Takata, Masatoshi Inden. Role of ERM proteins in the regulation of inflammatory cytokine expression in activated microglia. J Alzheimer Dis. In press.

Hisaka Kurita, Misa Ueda, Miyu Kimura, Kazuki Ohuchi, Isao Hozumi, Masatoshi Inden. Zinc deficiency decreases neurite extension via CRMP2 signal pathway. Biol Pharm Bull. 2024;47:796-800.

Shinnosuke Takizawa, Kazuki Ohuchi, Ayaka Fujimaki, Taisei Ito, Takanori Murakami, Hisaka Kurita, Masatoshi Inden. Effects of α7 nicotinic acetylcholine receptor agonist against α-synuclein-induced neurotoxicity. Neurosci Lett. 2024;823:137654.

Hisaka Kurita, Haruka Masuda, Ayu Okuda, Suzuna Go, Kazuki Ohuchi, Hiroki Yoshioka, Masatake Fujimura, Isao Hozumi, Masatoshi Inden. Epigenetic alternations in the SYP and DLG4 genes due to low-level methylmercury exposure during neuronal differentiation in vitro. J Appl Toxicol. 2024;44:1986-1996.

Junya Murata, Kazuki Ohuchi, Yuto Murayama, Ayane Mishima, Hisaka Kurita, Isao Hozumi, Masatoshi Inden. ETIC10/ONC201 Enhances Phosphate Uptake in the Human Neuroblastoma Cell Line SH-SY5Y. BPB reports. 2024;7:96-100.

Sora Nozaki, Masanori Hijioka, Xiaopeng Wen, Natsumi Iwashita, Junya Namba, Yoshiaki Nomura, Aoi Nakanishi, Soichiro Kitazawa, Ryo Honda, Yuji O Kamatari, Ryo Kitahara, Kenji Suzuki, Masatoshi Inden, Yoshihisa Kitamura. Galantamine suppresses α-synuclein aggregation by inducing autophagy via the activation of α7 nicotinic acetylcholine receptors. J Pharmacol Sci. 2024;156:102-114.

Hisaka Kurita, Naoki Hirasawa, Saori Yabe, Ayu Okuda, Takanori Murakami, Kazuki Ohuchi, Aya Ogata, Hiroki Yoshioka, Akiyoshi Kakita, Isao Hozumi，Masatoshi Inden. MicroRNA-5572 is associated with endoplasmic reticulum stress responses in low zinc treated and SOD1 G85R-transfected HEK293 cells. Biol Pharm Bull. 2024;47:796-800.

Sora Sakamoto, Yuichi Riku, Teiko Komori Nomura, Akio Kimura, Naoki Yamahara, Kazuki Ohuchi, Mari Yoshida, Yasushi Iwasaki, Takayoshi Shimohata, Masatoshi Inden, Ryo Honda. Ultrasensitive detection of TDP-43 and Amyloid-β protein aggregates using micelle-assisted seed amplification assay. Translational Neurodegeneration. 2024;13:51.

Hijiri Shinagawa, Kazuki Ohuchi, Yuya Goto, Kohei Hashimoto, Hideki Kijima, Shogo Maekawa, Hisaka Kurita, Masatoshi Inden. Vacuolar protein-sorting proteins are reduced even before cognitive decline in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2023;96:1011-1017.

Inden M[a], Kimura Y, Nishii K, Masaka T, Takase N, Tsutsui M, Kurita H, Ohuchi K, Hozumi I. Role of phosphate transporter PiT-2 in the pathogenesis of primary brain calcification. Biochem Biophys Res Commun. 2023;640:21-25. ([a]Correspondence)

Ayaka Fujimaki, Kazuki Ohuchi, Shinnosuke Takizawa, Takanori Murakami, Hisaka Kurita, Isao Hozumi, Xiaopeng Wen, Yoshihisa Kitamura, Zhiliang Wu, Yoichi Maekawa and Masatoshi Inden. The neuroprotective effects of FG-4592, a hypoxia-inducible factor prolyl-hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells. Sci Rep. 2023;13:15629.

Go S, Masuda H, Tsuru M, Inden M, Hozumi I[a], Kurita H[a]. Exposure to a low concentration of methylmercury in neural differentiation downregulates NR4A1 expression with altered epigenetic modifications and inhibits neuronal spike activity in vitro. Toxicol Lett. 2023;374:68-76. ([a]Correspondence)

Kawai K, Hirayama T, Imai H, Murakami T, Inden M, Hozumi I, Nagasawa H. Molecular imaging of labile heme in living cells using a small molecule fluorescent probe. J Am Chem Soc. 2022;144:3793-3803.

Ueda T, Ito T, Inden M, Kurita H, Yamamoto A, Hozumi I. Stem cells from human exfoliated deciduous teeth-conditioned medium (SHED-CM) is a promising treatment for amyotrophic lateral sclerosis. Front Pharmacol. 2022;13:805379.

Inden M, Kurita H, Hozumi I. Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification. J Pharmacol Sci. 2022;148:152-155. review.

Takase N, Inden M[a], Murayama Y, Mishima A, Kurita H, Hozumi I[a]. PDGF-BB is involved in phosphate regulation via the phosphate transporters in human neuroblastoma SH-SY5Y cells. Biochem Biophys Res Commun. 2022;593:93-100. ([a]Correspondence)

Go S[a], Kurita H[a], Hatano M, Matsumoto K, Nogawa H, Fujimura M, Inden M, Hozumi I. DNA methyltransferase- and histone deacetylase-mediated epigenetic alterations induced by low-level methylmercury exposure disrupt neuronal development. Arch Toxicol. 2021;95:1227-1239. ([a]equally contributed)

Tanaka N, Kimura S, Kamatari Y, Nakata K, Kobatake Y, Inden M, Yamato O, Urushitani M, Maeda S, Kamishina H. In vitro evidence of propagation of superoxide dismutase-1 protein aggregation in canine degenerative myelopathy. The Veterinary Journal. 2021;274:105710.

Kurita H, Ozawa K, Yamada M, Inden M, Hirata K, Hozumi I. Evaluation of headaches in primary brain calcification in Japan. Neurol Clin Neurosci. 2021;9:459-465.

Inden M, Takagi A, Kitai H, Ito T, Kurita H, Honda R, Kamatari Y, Nozaki S, Wen X, Hijioka M, Kitamura Y, Hozumi I. Kaempferol has potent protective and antifibrillogenic effects for alpha-synuclein neurotoxicity in vitro. Int J Mol Sci. 2021;22:11484.

Umetsu R, Tanaka M, Nakayama Y, Kato Y, Ueda N, Nishibata Y, Hasegawa S, Matsumoto K, Takeyama N, Iguchi K, Tanaka H, Hinoi E, Inagaki N, Inden M, Muto Y, Nakamura M. Neuropsychiatric adverse events of montelukast: an analysis of real-world dataset and drug−gene interaction network. Front Pharmacol. 2021;12:764279.

Kurita H, Yabe S, Ueda T, Inden M, Kakita A, Hozumi I. MicroRNA-5572 Is a Novel MicroRNA-Regulating SLC30A3 in Sporadic Amyotrophic Lateral Sclerosis. Int J Mol Sci. 2020;21:4482.

Takase N, Inden M, Hirai S, Yamada Y, Kurita H, Takeda M, Yamaguchi E, Itoh A, Hozumi I. The Novel gem-Dihydroperoxide 12AC3O Suppresses High Phosphate-Induced Calcification via Antioxidant Effects in p53LMAco1 Smooth Muscle Cells. Int J Mol Sci. 2020;21:4628.

Hijioka M, Kitamura K, Yanagisawa D, Nishimura K, Takata K, Inden M, Kitamura Y. Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke. J Pharmacol Sci. 2020;144:183-187.

Okazaki T, Saito D, Inden M, Kawaguchi K, Wakimoto S, Nakahari T, Asano S. Moesin is involved in microglial activation accompanying morphological changes and reorganization of the actin cytoskeleton. J Physiol Sci. 2020;70:52.

Ito T[a], Inden M[a], Ueda T, Asaka Y, Kurita H, Hozumi I. The neuroprotective effects of activated α7 nicotinic acetylcholine receptor against mutant copper-zinc superoxide dismutase 1-mediated toxicity. Sci Rep. 2020;10:2215. ([a]equally contributed)

Uno A, Tamune H, Kurita H, Hozumi I, Yamamoto N. SLC20A2-Associated Idiopathic Basal Ganglia Calcification-Related Recurrent Psychosis Response to Low-Dose Antipsychotics: A Case Report and Literature Review. Cureus. 2020;12:e12407.

Ueda T, Inden M, Ito T, Kurita H, Hozumi I. Characteristics and Therapeutic Potential of Dental Pulp Stem Cells on Neurodegenerative Diseases. Front Neurosci. 2020;14:407. review.