論文・原著
論文・原著
2022 2021 2020 2019 2018 2017 2016
2026
2．Sugiyama Y,Koizumi J,Kondo H,Takahashi K,Tanaka R,Suzuki M,Suzuki T,Oshiro M,Sato Y,Hayakawa M, Ito Y,Torii Y,Koshizuka T.
Postnatal Cytomegalovirus Infection in Preterm Infants ≤28 Weeks: Maternal IgG Effector Function, Risk Factors, Viral Kinetics in Relation to Symptom Onset, and Clinical Outcomes in a Prospective Multicenter Study． J Infect Dis 2026 May: jiag259. doi：10.1093/infdis/jiag259
1．Kawashima S, Takahashi K, Yanagisawa D, Irikura C, Kondo H, Inoue N, Koizumi J, Koshizuka．
Immunogenicity and plasmid delivery pathways of non-invasive Lactococcus lactis-vectored mucosal DNA vaccination．Infection and Immunity
2026 94(1):e0046025. doi： 10.1128/iai.00460-25
2025
2．Takasu S, Nagasaki Y, Koizumi J, Koshizuka T, Esaka Y.
Simple and sensitive LC-MS analysis of short chain fatty acids in cecum content and feces in mice: A derivatization-free approach．J Chromatogr A 2025 Oct 1760:466263. doi: 10.1016/j.chroma.2025.466263.
1．Hiroki Kondo, Juri Koizumi, Keita Takahashi, Tetsuo Koshizuka.
Evaluation of the Antiherpes Simplex Virus Activities of Thiourea-Based Compounds. Microbiology and Immunology, 2025 Aug 03; doi:10.1111/1348-0421.70005
2024
2．Koshizuka T, Sasaki Y, Kondo H, Koizumi J, Takahashi K．
Downregulation of CD86 in HCMV-infected THP-1 cells. Microbiology and Immunology, 2024 Oct 09 68(12)):406-413； doi: 10.1111/1348-0421.13176.
1．Ayato Tsujii, Keita Takahashi, Haruki Harada, Sarana Kawashima, Hina Oikawa, Hiroki Fukushima, Yuta Hayakawa, Juri Koizumi, Naoki Inoue, Tetsuo Koshizuka．
Evaluation of the protective effect of the intranasal vaccines adjuvanted with bacterium-like particles against intestinal infection．Vaccine, 2024 May 9; doi:10.1016/j.vaccine.2024.05.023
2023
6．Juri Koizumi, Keisuke Nakase, Hidemasa Nakaminami.
Emergence of Cutibacterium avidum with erm(X) on a Mobile Genetic Element Identical to That of Cutibacterium acnes. Microbiol Resour Announc, 2023 Jun ;doi: 10.1128/mra.00178-23
5．Juri Koizumi, Keisuke Nakase, Norihisa Noguchi, Hidemasa Nakaminami.
Avidumicin, a novel cyclic bacteriocin, produced by Cutibacterium avidum shows anti-Cutibacterium acnes activity. J Antibiot, 2023 Jun ;DOI:10.1038/s41429-023-00635-w
4．Sahya Koyanagi, Juri Koizumi, Keisuke Nakase, Nobukazu Hayashi, Yuki Horiuchi, Kaoru Watanabe, Toshiya Asai, Akiko Yamazaki, Emi Nakazaki, Hidemasa Nakaminami.
Increased frequency of clindamycin-resistant Cutibacterium acnes strains isolated from Japanese patients with acne vulgaris caused by the prevalence of exogenous resistance genes. J Dermatol. 2023 Jun; 50(6):793-799. DOI：10.1111/1346-8138.16757
3．Keisuke Yamaguchi, Hiroyuki Shimizu, Keita Takahashi, Takamasa Nagatomo, Tomohiro Nishimura, Miyuki Matsumoto, Tetsuo Koshizuka, Hiroaki Mori, Naoki Inoue, Masaharu Torikai.
Characterization of epitopes of human monoclonal antibodies against cytomegalovirus glycoprotein B for neutralization and antibody-dependent phagocytosis．Vaccine, 2023 Jun, ; DOI:10.1016/j.vaccine.2023.06.003
2．Kazufumi Ikuta,Ryoko Kanno,Tomoaki Bessho,Tetsuo Koshizuka,Tatsuo Suzutani．
Evaluation of Toxoplasma gondii IgG avidity assays through a comparison of IgM serostatus．Diagnostic Microbiology & Infectious Disease, 2023 Jan, ; DOI:10.1016/j.diagmicrobio.2023.115901
1．Haruka Sudo, Nagisa Tokunoh, Ayato Tsujii, Sarana Kawashima, Yuta Hayakawa, Hiroki Fukushima, Keita Takahashi,Tetsuo Koshizuka and Naoki Inoue.
The adjuvant effect of bacterium-like particles (BLPs) depends on the route of administration. Frontiers in Immunology, 2023 Jan, ; DOI:10.3389/fimmu.2023.1082273
2022
2．Keisuke Satoh,Keita Takahashi,Kazuma Noguchi,Yuhki Kobayashi,Ryuichi Majima,Yoshihiko Iwase,Keisuke Yamaguchi,Yukina Masuda,Tetsuo Koshizuka,Naoki Inoue．
Characterization of the Second Apoptosis Inhibitor Encoded by Guinea Pig Cytomegalovirus．Jornal of Virology, 2022 Dec ; DOI: 10.1128/jvi.01622-22
1．Minegaki N, Koshizuka T, Hatasa K, Kondo H, Kato H, Tannaka M, Takahashi K, Tsuji M, Inoue N．
The C-terminal penta-peptide repeats of major royal jelly protein 3 ameliorate the progression of inflammation in vivo and in vitro.
Biol Pharm Bull, 45(5)：583-589,2022. DOI: 10.1248/bpb.b21-00922
2021
3．Kondo H, Koshizuka T, Majima R, Takahashi K, Ishioka K, Suzutani T, Inoue N.
Characterization of a thiourea derivative that targets viral transactivators of cytomegalovirus and herpes simplex virus type 1. Antiviral Research 2021, 2021 Dec；196:105207; DOI:10.1016/j.antiviral.2021.105207
2．Koshizuka T, Kondo H, Kato H, Takahashi K.
Human cytomegalovirus UL42 protein inhibits the degradation of glycoprotein B through inhibition of Nedd4 family ubiquitin E3 ligases. Microbiol Immunol. 2021 Nov;65(11):472-480 doi: 10.1111/1348-0421.12932.
1．Takahashi K, Sugiyama T, Tokunoh N, Tsurumi S, Koshizuka T and Inoue N.
Intimate Adhesion Is Essential for the Pathogen-Specific Inflammatory and Immune Responses in the Gut of Mice Infected with Citrobacter rodentium. Immuno Horizons 2021, 2021.Oct ; 5(10)870-883, :doi : 10.4049/immunohorizons.2100087
2020
7．Majima R, Koshizuka T, Inoue N.
The guinea pig cytomegalovirus GP119.1 gene encodes an IgG-binding glycoprotein that is incorporated into the virion. Microbiol. Immunol. 08 December 2020 doi: 10.1111/1348-0421.12867
6． Kanno R, Koshizuka T, Miyazaki N, Kobayashi T, Ishioka K, Ozaki C, Chiba H, Suzutani T.
Protection of Fatty Liver by the Intake of Fermented Soybean Paste, Miso, and Its Pre-Fermented Mixture. Foods, 2021. 10(2), 291. doi: 10.3390/foods10020291
5．Minegaki N, Koshizuka T, Nishina S, Kondo H, Takahashi K, Sugiyama T, Inoue N.
The carboxyl-terminal penta-peptide repeats of major royal jelly protein 3 enhance cell proliferation. Biol. Pharm. Bull. 2020;43(12):1911-1916. doi: 10.1248/bpb.b20-00607.
4．Kazuma Noguchi, Ryuichi Majima, Keita Takahashi, Yoshihiko Iwase, Souichi Yamada, Keisuke Satoh, Tetsuo Koshizuka, Naoki Inoue．
Identification and functional analyses of a cell-death inhibitor encoded by guinea pig cytomegalovirus gp38.1 in cell culture and in animals. J. Gen. Virol. 2020 Sep ; 101(12): doi: 10.1099/jgv.0.001493
3．Koshizuka T, Inoue N．
Activation of c-Jun by human cytomegalovirus UL42 through JNK activation. PLoS One. 2020 May;15(5):e0232635. doi: 10.1371/journal.pone.0232635
2．Okumura M, Matsuura-Miura M, Makino R, Miura T, Noguchi K, Majima R, Koshizuka T, Inoue N．
Enhancement of guinea pig cytomegalovirus infection by two endogenously expressed components of the pentameric glycoprotein complex in epithelial cells. Scientific Reports, 2020 May ; 10: 8530 (2020) doi: 10.1038/s41598-020-65545-5
1．Takahashi K, Orito N, Yanagisawa D, Yano A, Mori Y, Inoue N．
Eosinophils are the main cellular targets for oral gene delivery using Lactic acid bacteria. Vaccine, 2020 Mar ; 38:3330-3338, doi:10.1016/j.vaccine.2020.02.084
2019
4．Kotani H, Koshizuka T, Matsubara K, Nishiyama K, Sugiyama T, Suzutani T.
Relationship between Human β-defensin 2 and the vaginal environment. Jpn J Infect Dis. 2019 Dec . doi: 10.7883/yoken.JJID.2019.190.
3．Takahashi K, Orito N, Tokunoh N, Inoue N．
Current issues regarding the application of recombinant lactic acid bacteria to mucosal vaccine carriers. Applied Microbiology and Biotechnology. 2019 Aug; 103(15):5947-5955. doi: 10.1007/s00253-019-09912-x.
2．Ikuta K, Koshizuka T, Kanno R, Inoue N, Kubo T, Koyano S, Suzutani T.
Evaluation of the indirect and IgM-capture anti-human cytomegalovirus (CMV) IgM ELISA methods as confirmed by CMV IgG avidity. Microbiol Immunol. 2019 Apr ; 63(5):172-178. doi: 10.1111/1348-0421.12683.
1．Takahashi K, Hanamura Y, Tokunoh N, Kassai K, Matsunishi M, Watanabe S, Sugiyama T, Inoue N．
Protective effects of oral immunization with formalin-inactivated whole-cell Citrobacter rodentium on Citrobacter rodentium infection in mice. Journal of Microbiological Methods. 2019 Apr; 159:62-68. doi:10.1016/j.mimet.2019.02.016 .
2018
9．Kotani H, Matsubara K, Koshizuka T, Nishiyama K, Kaneko H, Tasaka M,Sugiyama T, Suzutani T.
Human β-defensin 2 as a biochemical indicator of vaginal environment in pregnant woman.Hypertension Reserch in Pregnancy. 2018,6:68-72 doi: 10.14390/jsshp.HRP2018-005
8．Koshizuka T, Matsuda Y, Suzuki H, Kanno R, Ikuta K, Kobayashi T, Kondo T, Okada Y, Suzutani T.
Detection of engraftment of donor-derived antibody producing cells in a lung transplant recipient by anti-cytomegalovirus IgG avidity test.Transplant Immunol, 2019 Apr; 53:34-37. doi: 10.1016/j.trim.2018.12.003.
7．Nishiyama K, Kobayashi T, Sato Y, Watanabe Y, Kikuchi R, Kanno R, Koshizuka T, Miyazaki N, Ishioka K, Suzutani T.
A Double-Blind Controlled Study to Evaluate the Effects of Yogurt Enriched with Lactococcus lactis 11/19-B1 and Bifidobacterium lactis on Serum Low-Density Lipoprotein Level and Antigen-Specific Interferon-γ Releasing Ability. Nutrients. 2018 Nov ;10(11). pii: E1778. doi: 10.3390/nu10111778.
6．Koshizuka T, Toriyabe K, Sato Y, Ikuta K, Ikeda T, Suzutani T.
Congenital cytomegalovirus infection via a re-infected mother with original antigenic sin: A case report. Int J Infect Dis. 2018 Oct ;77:87-89.doi: 10.1016/j.ijid.2018.10.006.
5．Takahashi K, Yano A, Watanabe S, Philippe Langella, Luis G. Bermúdez-Humarán, Inoue N．
M-cell targeting strategy enhances systemic and mucosal immune responses induced by oral administration of nuclease-producing L. lactis．Applied Microbiology and Biotechnology. 2018 Dec ;102(24):10703-10711. doi:10.1007/s00253-018-9427-1
4．Koshizuka T, Sato Y, Kobiyama S, Oshima M, Suzutani T.
A two-step culture method utilizing secreted luciferase recombinant virus for the detection of anti-cytomegalovirus compounds. Micorbiol. Immunol. 2018 Oct;62(10):651-658. doi: 10.1111/1348-0421.12645
3．Kobayashi R, Abe M, Oguri K, Torikai M, Nishimura T, Mori H, Koshizuka T, Inoue N.
Analysis of relationships between polymorphisms in the genes encoding the pentameric complex and neutralization of clinical cytomegalovirus isolates. Vaccine. 2018 Sep; 36(40):5983-5989. doi:10.1016/j.vaccine.2018.08.054
2．Yano A, Takahashi K, Mori Y, Watanabe S, Hanamura Y, Sugiyama T, Inoue N.
Peyer's patches as a portal for DNA delivery by Lactococcus lactis in vivo. Biol Pharm Bull, 41:1-9, 2018. doi: 10.1248/bpb.b17-00657 https://www.jstage.jst.go.jp/article/bpb/41/2/41_b17-00657/_pdf/-char/en
1．Koshizuka T, Kobayashi T, Ishioka K, Suzutani T.
Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases. Sci. Rep. 2018 volume 8, Article number: 4447
doi:10.1038/s41598-018-22682-2
2017
3．Minoura K, Yamada M, Mizoguchi T, Kaneko T, Nishiyama K, Ozminskyj M, Koshizuka T, Suzutani T.
Antibacterial Effect of Artificial Surface of Nanoimprinted Moth-eye Film.
PLoS One 2017 Sep 21;12(9):e0185366. DOI: 10.1371/journal.pone.0185366
2．Kobayashi T, Sato JI, Ikuta K, Kanno R, Nishiyama K, Koshizuka T, Ishioka K, Suzutani T.
Modification of the HCMV-specific IFN-γ release test (QuantiFERON-CMV) and a novel proposal for its application.
Fukushima J Med Sci. 2017 Aug 9;63(2):64-74. doi: 10.5387/fms.2017-01
1．Sato Y, Koshizuka T, Ishibashi K, Hashimoto K, Ishioka K, Ikuta K, Yokota S, Fujii N, Suzutani T.
Involvement of herpes simplex virus type 1 UL13 protein kinase in the induction of SOCS genes, the negative regulator of cytokine signaling.
Microbiol Immunol. 2017 May;61(5):159-167. doi: 10.1111/1348-0421.12483
2016
2．Koshizuka T, Ishioka K, Kobayashi T, Ikuta K, Suzutani T.
Protection from lethal herpes simplex virus type 1 infection by vaccination with a UL41-deficient recombinant strain.
Fukushima J Med Sci. 2016 Jun 8;62(1):36-42. doi: 10.5387/fms.2015-24
1．Koshizuka T, Tanaka K, Suzuani T.
Degradation of host ubiquitin E3 ligase Itch by human cytomegalovirus UL42.
J. Gen. Virol. 2016 Jan;97: 196-208. doi: 10.1099/jgv.0.000336