医療薬剤学大講座 臨床薬剤学研究室
Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University

論文等 発表(2008~)


  1. Kamiya T, Mizuno N, Hayashi K, Otsuka T, Haba M, Abe N, Oyama M, Hara H: Methoxylated Flavones from Casimiroa edulis La Llave Suppress MMP9 Expression via Inhibition of the JAK/STAT3 Pathway and TNFα-Dependent Pathways. J. Agric. Food Chem., 72(26), 14678-14683, 2024
  2. Tanaka S, Hayashi S, Otsuka T, Kamiya T, Ishikawa K, Hara H: Inhibition of glutamine metabolism increases sensitivity to plasma-activated medium-induced cytotoxicity. Free Radic. Res., 58(3), 170-179, 2024
  3. Hara H, Manome A, Kamiya T: Panobinostat, a Histone Deacetylase Inhibitor, Reduces LPS-Induced Expression of Inducible Nitric Oxide Synthase in Rat Immortalized Microglia HAPI Cells. Biol. Pharm. Bull., 47(6), 1196-1203, 2024
  4. Ogawa E, Suzuki N, Kamiya T, Hara H: Sebacic acid, a royal jelly-containing fatty acid, decreases LPS-induced IL-6 mRNA expression in differentiated human THP-1 macrophage-like cells. J. Clin. Biochem. Nutr., 74(3), 192-198, 2024


  1. Takahashi Y, Otsuka T, Arakawa R, Naito A: Inhibition of heat shock protein 90 lowered intraocular pressure without affecting the production of aqueous humor in rabbits. Ophthalmic Res. 67 (1), 23-28, 2023
  2. Tominaga S, Yoshioka H ,Yokota S ,Tsukiboshi Y, Suzui M, Nagai M, Hara H, Maeda T, Miura N: Copper-induced diurnal hepatic toxicity is associated 1 with Cry2 and Per1 in mice. Environ. Health Prev. Med., 28, 78, 2023
  3. Kamiya T, Kadowaki M, Atobe T, Kunieda K, Morimoto K, Hara H: Inhibition of N-glycosylation by glucosamine hydrochloride inhibits TGF-β1-induced LOXL2 secretion. J. Cell Biochem. doi: 10.1002/jcb.30404.
  4. Inoue Y, Kamiya T, Hara H:Increased expression of ELOVL7 contributes to production of inflammatory cytokines in THP-1 cell-derived M1-like macrophages. J. Clin. Biochem. Nutr., February 2023 DOI:10.3164/jcbn.22-69.


  1. Kamiya T: Copper in the tumor microenvironment and tumor metastasis. J Clin Biochem Nutr. 71, 22-28, 2022. doi: 10.3164/jcbn.22-9.
  2. Inoue Y, Ienaga M, Kamiya T, Adachi T, Ohta M, Hara H:Royal jelly fatty acids downregulate ANGPTL8 expression through the decrease in HNF4α protein in human hepatoma HepG2 cells. Biosci. Biotechnol Biochem. 24;86(6), 747-754,2022 doi: 10.1093/bbb/zbac043.
  3. Kamiya T, Yamaguchi Y, Oka M, Hara H: Combined action of FOXO1 and superoxide dismutase 3 promotes MDA-MB-231 cell migration, Free Radic Res. 56, 106-114,2022


  1. Kondo M, Hara H, Kamijo F, Kamiya T, Adachi T: 6-Hydroxydopamine disrupts cellular copper homeostasis in human neuroblastoma SH-SY5Y cells. Metallomics, 13(7), mfab041, 2021
  2. Takemoto R, Kamiya T, Atobe T, Hara H, Adachi T: Regulation of lysyl oxidase expression in THP-1 cell-derived M2-like macrophages. J. Cell. Biochem., 122(8), 777-786, 2021
  3. Hara H, Adachi T: Molecular mechanisms of non-thermal atmospheric pressure plasmainduced cellular responses.Jpn. J. Appl. Phys. 60, 020501,2021
  4. 原 宏和, 足立哲夫:大気圧低温プラズマに対する細胞応答とがん治療への展開:大気圧低温プラズマによる細胞のエネルギー産生障害の分子機構,プラズマ・核融合学会誌,97(3), 123-128, 2021


  1. Ishii R, Kamiya T, Hara H, Adachi T: Hyperthermia synergistically enhances cancer cell death by plasma-activated acetated Ringer’s solution. Arch. Biochem. Biophys. 693, 108565, 2020
  2. Hirata T, Arai Y, Yuasa S, Abe Y, Takayama M, Sasaki T, Kunitomi A, Inagaki H, Endo M, Morinaga J, Yoshimura K, Adachi T, Oike Y, Takebayashi T, Okano H, Hirose N: Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages. Nature Commun. 11, 3820, 2020
  3. Goto N, Hara H, Kondo M, Yasuda N, Kamiya T, Okuda K, Adachi T: Hydrogen sulfide increases copper-dependent neurotoxicity via intracellular copper accumulation. Metallomics. 12, 868-875, 2020
  4. Adachi T, Matsuda Y, Ishii R, Kamiya T, Hara H: Ability of plasma-activated acetated Ringer’s solution to induce A549 cell injury is enhanced by a pre-treatment with histone deacetylase inhibitors. J. Clin. Biochem. Nutr. 67 (3), 232-239, 2020
  5. Takemoto R, Kamiya T, Hara H, Adachi T: Lysyl oxidase expression is regulated by the H3K27 demethylase Jmjd3 in tumorassociated M2-like macrophages. J. Clin. Biochem. Nutr. 66(2), 110-115, 2020


  1. Nagaya M, Hara H, Kamiya T, Adachi T: Inhibition of NAMPT markedly enhances plasma-activated mediuminduced cell death in human breast cancer MDA-MB-231 cells. Arch. Biochem. Biophys. 676, 108155, 2019
  2. Kamiya T, Tanaka M, Hara H, Yamaguchi E, Itoh A, Adachi T: Inhibitory effects of 4-hydroperoxy-2-decenoic acid ethyl ester on phorbol ester- and TGF-β1-induced MMPs expression. Free Rad. Res. 53(11-12), 1051-1059, 2019
  3. Hara H, Kobayashi M, Shiiba M, Kamiya T, Adachi T: Sublethal treatment with plasma-activated medium induces senescence-like growth arrest of A549 cells: Involvement of intracellular mobile zinc. J. Clin. Biochem. Nutr. 65(1), 16-22, 2019


  1. Kamiya T, Watanabe M, Hara H, Mitsugi Y, Yamaguchi E, Itoh A, Adachi T: Induction of Human-Lung-Cancer-A549-Cell Apoptosis by 4-Hydroperoxy-2-decenoic Acid Ethyl Ester through Intracellular ROS Accumulation and the Induction of Proapoptotic CHOP Expression. J. Agric. Food Chem., 66, 10741-10747, 2018.
  2. Matsuzaki T, Kano A, Kamiya T, Hara H, Adachi T: Enhanced ability of plasma-activated lactated Ringer’s solution to induce A549 cell injury. Arch. Biochem. Biophys., 656, 19-30, 2018
  3. Adachi T: Molecular Mechanism of Cellular Responses to Nonthermal Plasma, Plasma Medical Science, Academic Press, 145-156, 2018
  4. Ichihara M, Kamiya T, Hara H, Adachi T: The MEF2A and MEF2D function as scaffold proteins that interact with HDAC1 or p300 in SOD3 expression in THP-1 cells. Free Rad. Res., 52, 799-807, 2018
  5. Hotta E, Hara H, Kamiya T, Adachi T: Non-thermal atmospheric pressure plasma-induced IL-8 expression is regulated via intracellular K+ loss and subsequent ERK activation in human keratinocyte HaCaT cells. Arch. Biochem. Biophys., 644, 64-71, 2018
  6. Nakashima K, Tomida J, Kamiya T, Hirai T, Morita Y, Hara H, Kawamura Y, Adachi T, Inoue M: Diaporthols A and B: Bioactive diphenyl ether derivatives from an endophytic fungus Diaporthe sp. Tetrahedron Lett., 59, 1212-1215, 2018
  7. Kamiya T, Takeuchi K, Fukudome S, Hara H, Adachi T: Copper chaperone antioxidant-1, Atox-1, is involved in the induction of SOD3 in THP-1 cells. BioMetals, 31(1) 61-68, 2018
  8. Inoue Y, Hara H, Mitsugi Y, Yamaguchi E, Kamiya T, Itoh A, Adachi T: 4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways. Neurochem. Int., 112, 288-296, 2018
  9. 神谷哲朗:レドックス制御機構としてのエピジェネティクス, 腎とフリーラジカル 第13集,東京医学社,40-45,2018
  10. 山田晴生,今井裕一,伊藤恭彦,足立哲夫:アナグリプチリン投与による脂質代謝改善が過酸化脂質に及ぼす影響,腎とフリーラジカル 第13集,東京医学社,113-117,2018
  11. 山田晴生,今井裕一,伊藤恭彦,足立哲夫:フェノフィブラートの抗炎症活性と腎機能への影響,腎とフリーラジカル 第13集,東京医学社,123-126,2018
  12. 山田晴生,今井裕一,伊藤恭彦,足立哲夫:血液透析で微細炎症がエリスロポエチンに及ぼす影響,腎とフリーラジカル 第13集,東京医学社,143-146,2018


  1. Mai Efdi, Antoni Pardede, Akinori Kakumu, Hirokazu Hara, Syafrizayanti, Dessy Arisanti, Masayuki Ninomiya and Mamoru Koketsu: Chemical constituents of Aglaia odorata leaves and their anti-inflammatory effects. Nat Prod Commun 12, 1717-1720, 2017
  2. Shimoji M, Hara H, Kamiya T, Okuda K, Adachi T: Hydrogen sulfide ameliorates zinc-induced cell death in neuroblastoma SH-SY5Y cells. Free Rad. Res., 51(11-12), 978-985, 2017.
  3. Doi N, Sasai Y, Yamauchi Y, Adachi T, Kuzuya M, Kondo Shin-ichi: Kinetic analysis of mechanoradical formation during the mechanolysis of dextran and glycogen. Beilstein J. Org. Chem., 13, 1174-1183, 2017
  4. Kamiya T, Nakahara R, Mori N, Hara H, Adachi T: Ten-eleven translocation 1 functions as a mediator of SOD3 expression in human lung cancer A549 cells.Free Rad. Res., 51(3), 329-336, 2017
  5. Hara H, Sueyoshi S, Taniguchi M, Kamiya T, Adachi T: Differences in intracellular mobile zinc levels affect susceptibility to plasma-activated medium-induced cytotoxicity. Free Rad. Res., 51(3), 306-315, 2017
  6. Ohashi A, Yasuda H, Kamiya T, Hara H, Adachi T: CAPE increases the expression of SOD3 through epigenetics in human retinal endothelial cells. J. Clin. Biochem. Nutr., 61(1), 6-13, 2017
  7. Doi N, Sasai Y, Yamauchi Y, Adachi T, Kuzuya M, Kondo Shin-ichi: A Novel polymeric prodrugs synthesized by mechanochemical solid-state copolymerization of glucose-based polysaccharides and vinyl monomers. Int. J. Pharm. Sci. Invent., 6(1), 38-46, 2017
  8. Horiba M, Kamiya T, Hara H, Adachi T: Cytoprotective effects of mild plasma-activated medium against oxidative stress in human skin fibroblasts.Sci. Rep., 7, 42208, 2017
  9. Morisawa S, Yasuda H, Kamiya T, Hara H, Adachi,T: TNF-α decreases EC-SOD expression through DNA methylation.J. Clin. Biochem. Nutr., 60(3), 169-175, 2017
  10. Adachi T: Introduction to serial reviews: Biomedical application of non-thermal atmospheric pressure plasma and its usefulness. J. Clin. Biochem. Nutr., 60(1), 1-2, 2017
  11. Hara H, Kimoto D, Kajita M, Takada C, Kamiya T, Adachi T: Apomorphine prevents LPS-induced IL-23 p19 mRNA expression via inhibition of JNK and ATF4 in HAPI cells. Eur. J. Pharmacol., 795, 108-114, 2017


  1. 神谷哲朗,安田浩之,原 宏和,山田晴生,足立哲夫: EC-SOD,腎と透析,81 (6), 964-970,2016
  2. 山田晴生,足立哲夫,今井裕一:腎炎,腎と透析,81 (6), 982-986,2016
  3. Ohta F, Kizuka Y, Kitazume S, Adachi T, Taniguchi N: N-Glycosylation is essential for secretion of extracellular superoxide dismutase. FEBS Lett., 590, 3357-3367, 2016
  4. Hattori S, Kamiya T, Hara H, Ninomiya M, Koketsu M, Adachi T: CoCl2 decreases EC-SOD expression through histone deacetylation in COS7 cells. Biol Pharm. Bull. 39, 2036-2041, 2016
  5. Adachi T, Kano A, Nonomura S, Kamiya T, Hara H: Histone deacetylase inhibitors stimulate the susceptibility of A549 cells to a plasma-activated medium treatment. Arch. Biochem. Biophys., 606, 120-127, 2016
  6. Yasuda H, Ohashi A, Nishida S, Kamiya T, Suwa T, Hara H, Takeda J, Itoh Y, Adachi T : Exendin-4 induces extracellular-superoxide dismutase through histone H3 acetylation in human retinal endothelial cells. J. Clin. Biochem. Nutr.  59, 174-181, 2016
  7. Makino J, Ogasawara R, Kamiya T, Hara H, Mitsugi Y, Yamaguchi E, Itoh A, Adachi T: Royal jelly constituents increase the expression of extracellular superoxide dismutase through histone acetylation in monocytic THP-1 Cells. J. Natl. Prod. 79(4), 1137-1143, 2016
  8. Kamiya T, Goto A, Kurokawa E, Hara H, Adachi T: Cross-talk mechanism among EMT, ROS, and histone acetylation in phorbol ester-treated human breast cancer MCF-7 cells. Oxid. Med. Cell. Longev. 2016 ID1284372, 2016
  9. Makino J, Asai R, Hashimoto M, Kamiya T, Hara H, Nimomiya M, Koketsu M, Adachi T: Suppression of EC-SOD by oxLDL During Vascular Smooth Muscle Cell Proliferation. J. Cell. Biochem. 117, 2496-2505, 2016
  10. Nakahara R, Makino J, Kamiya T, Hara H, Adachi T: Caffeic acid phenethylester suppresses monocyte adhesion to the endothelium by inhibiting NF-KB/NOX2-derived ROS signaling. J. Clin. Biochem. Nutr., 58(3) 174-179, 2016
  11. Adachi T, Nonomura S, Horiba M, Hirayama T, Kamiya T, Nagasawa H, HaraH: Iron stimulates plasma-activated medium-induced A549 cell injury. Sci. Reports 6, 20928, 2016
  12. Yasuda H, Mizukami K, Hayashi M, Kamiya T, Hara H, Adachi T: Exendin-4 promotes extracellular-superoxide dismutase expression in A549 cells through DNA demethylation. J. Clin. Biochem. Nutr. 58(1), 34-39, 2016


  1. 田中宏昌,水野正明,豊國伸哉,丸山彰一,小寺泰弘,足立哲夫,寺崎浩子,加藤昌志,吉川史隆,堀勝:プラズマが誘導する生体応答とそのバイオ・医療応用:プラズマ活性溶液の細胞影響.プラズマ・核融合学会誌,91(12),776-779, 2015
  2. Tanaka H, Mizuno M, Toyokuni S, Maruyama S, Kodera Y, Terasaki H,Adachi T, Kato M, Kikkawa F, Hori M: Cancer therapy using non-thermal atmospheric pressure plasma with ultra-high electron density. Physics of Plasma, 22, 122004, 2015.
  3. Maehata Y, Miyamoto C, Tsukinoki T, Takahashi S, Yoshino F, Wada-Takahashi S, Yoshida A, Tanaka A, Adachi T, Igoshi N, Shiba T, Kishikawa N, Imazato T, Suzuki I, Ihara H, Shumonura H, Okabe H, Yanagisaawa T, Hosho A, Maehata E: Foresight of physical development indicated by the national health and nutrition survey in Japan: An approach in terms of biomedical sciences. Int. J. Anal. Bio-Sci., 3, 63-72, 2015
  4. Tanaka H, Mizuno M, Ishikawa K, Kondo H, Takeda K, Hashizume H, Nakamura K, Utsumi F, Kajiyama H, Kano H, Okazaki Y, Toyokuni S, Akiyama S, Maruyama S, Yamada S, Kodera Y, Kaneko H, Terasaki H, Hara H, Adachi T, Iida M, Yajima I, Kato M, Kikkawa F, Hori M: Plasma with high electron density and plasma-activated medium for cancer treatment. Clinical Plasma Medicine, 3, 72-76, 2015
  5. Doi N, Sasai Y, Yamauchi Y, Adachi T, Kuzuya M, Kondo S: Development of novel polymeric prodrugs synthesized by mechanochemical solid-state copolymerization of hydroxyethylcellulose and vinyl monomers, Chem. Pharm. Bull., 63, 992-997, 2015
  6. Chen GF, Sudhahar V, Youn SW, Das A, Cho J, Kamiya T, Urao N, McKinney RD, Surenkhuu B, Hamakubo T, Iwanari H, Li S, Christman JW, Shantikumar S, Angelini GD, Emanueli C, Ushio-Fukai M, Fukai T: Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function, Sci Rep., 5, 14780, 2015
  7. Hara H, Taniguchi M, Kobayashi M, Kamiya T, Adachi T: Plasma-activated medium-induced intracellular zinc liberation causes death of SH-SY5Y cells, Arch. Biochem. Biophys., 584, 51-60, 2015
  8. Doi T, Hara H, Kajita M, Kamiya T, Adachi T: Zinc regulates expression of IL-23 p19 mRNA via activation of eIF2α/ATF4 axis in HAPI cells, BioMetals, 28(5), 891-902, 2015
  9. Makino J, Nii M, Kamiya T, Hara H, Adachi T: Oxidized low-density lipoprotein accelerates the destabilization of extracellular-superoxide dismutase mRNA during foam cell formation, Arch. Biochem. Biophys., 575, 54-60. 2015
  10. Adachi T, Tanaka H, Nonomura S, Hara H, Kondo S, Hori M: Plasma-activated medium induced A549 cell injury by a spiral apoptotic cascade involving the mitochondrial-nuclear network, Free Rad. Biol. Med., 79, 28-44, 2015


  1. Maehata Y, Maehata K, Adachi T, Tanaka A, Ikoshi N, Kuroda N, Kishikawa N, Shiba T, Matsushita M, Yanagisawa T, Maehata E, Shimomura H: EC-SOD levels in pre-dialysis sera and the relationship with HOMA-R, Int. J. Anal. Bio-Sci., 2(4), 155-162, 2014
  2. Kamezaki F, Tsutsui M, Takahashi M, Sonoda S, Kubo T, Fujino Y, Adachi T, Abe H, Takeuchi M, Mayumi T, Otsuji Y: Plasma levels of nitric oxide metabolites are markedly reduced in normotensive men with electrocardiographically determined left ventricular hypertrophy, Hypertension, 114, e03287, 2014
  3. Hara H, Ikeda R, Ninomiya M, Kamiya T, Koketsu M, Adachi T: Newly synthesized 'hidabeni' chalcone derivatives potently suppress LPS-induced NO production via inhibition of STAT1, but not NF-κB, JNK, and p38, pathways in microglia, Biol. Pharm. Bull., 37, 1042-1049, 2014
  4. Adachi T, Kaminaga T, Yasuda H, Kamiya T, Hara H: The involvement of endoplasmic reticulum stress in bile acid-induced hepatocellular injury, J. Clin. Biochem. Nutr., 54(1), 129-135, 2014
  5. 山田晴生,足立哲夫,山田裕一,今井裕一:腎性貧血にESA製剤の切り替え投与に伴う炎症指標の推移,腎とフリーラジカル 第12集, 東京医学社,58-61,2014
  6. 山田晴生,足立哲夫,山田裕一,今井裕一:Teriparatide投与による腎でのextracellular superoxide dismutase (EC-SOD)産生誘導,腎とフリーラジカル 第12集, 東京医学社,86-89,2014
  7. 神谷哲朗,服部脩平,原 宏和,山田晴生,足立哲夫:低酸素状態下のCOS7細胞におけるEC-SOD発現調節機構としてのエピジェネティクス,腎とフリーラジカル 第12集, 東京医学社,100-103,2014


  1. Makino J, Nakanishi R, Kamiya T, Hara H, Ninomiya M, Koketsu M, Adachi T: Luteolin suppresses the differentiation of THP-1 cells through the inhibition of NOX2 mRNA expression and the membrane translocation of p47phox, J. Nat. Prod., 76, 1285-1290, 2013
  2. Hara H, Takeda T, Yamamoto N, Furuya K, Hirose K, Kamiya T, Adachi T:Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS, FEBS J., 280, 3313-3327, 2013
  3. Kamiya T, Machiua M, Makino J, Hara H, Hozumi I, Adachi T: Epigenetic regulation of extracellular-superoxide dismutase in human monocytes, Free Rad. Biol. Med., 61, 197-205, 2013 [PubMed]
  4. Uto-Kondo H, Ayaori M, Kishimoto Y, Adachi T, Takiguchi S, Yakushuji E, Sasaki M, Komatsu T, Kondo K, Ikewaki K: Consumption of polyphenol-rich juar tea increases endothelium-bound extracellular superoxide dismutase levels in men with metabolic syndrome: link to LDL oxidizability, Int. J. Food Sci. Nutr., 64, 407-414, 2013
  5. Hara H, Maeda A, Kamiya T, Adachi T: Protective Effects of Apomorphine against Zinc-Induced Neurotoxicity in Cultured Cortical Neurons, Biol. Pharm. Bull., 36, 585-591, 2013
  6. Kamiya T, Hara H, Adachi T: Effect of ER stress inducer thapsigargin on the expression of extracellular-superoxide dismutase in mouse 3T3-L1 adipocytes, J. Clin. Biochem. Nutr., 52, 101-105, 2013
  7. Oyama M, Nakashima K, Kamiya T, Haba M, Ito T, Murata H, Tanaka T, Adachi T, Iinuma M, Kinoshita T: Flavonoids isolated from the leaves of Melicope triphylla and their extracellular-superoxide dismutase-inducing activity, Phytochemistry Lett., 6, 215-218 , 2013
  8. 阿久津和夫,森 宏之,柳沢昊永,芽原 紘,植木幸孝,平方尚之,今里孝宏,足立哲夫,下村弘治,前畑英介: 五穀玄米粉(湿式焙煎)に潜む栄養力と抗酸化能:高ORAC値に期する機能性.医学と生物学,157(1), 135-142, 2013
  9. 神谷哲朗,小原 彩,和泉美里,原 宏和,山田晴生,足立哲夫: カドミウム曝露下のCOS-7細胞におけるextracellular-superoxide dismutase発現変動,腎とフリーラジカル 第11集, 東京医学社,63-66,2013
  10. 山田晴生,山田裕一,足立哲夫,今井裕一: 塩酸ジラゼプの細胞周期・フリーラジカル産生に及ぼす影響,腎とフリーラジカル 第11集,127-133,2013
  11. 山田晴生,足立哲夫,山田裕一,今井裕一: プタバスタチンによるlow density lipoprotein (LDL)結合serum amyloid (SAA)を指標とした抗炎症効果と腎保護作用, 腎とフリーラジカル 第11集,170-175,2013


  1. 藤井友和,神谷恒行,足立哲夫:がん化学療法における薬剤師業務の拡大とその評価に関する研究.岐阜薬科大学紀要,61, 19-27, 2012
  2. Kamiya T, Nishihara H, Hara H, Adachi T: Ethanol extract of Brazilian red propolis induces apoptosis in human breast cancer MCF-7 cells through endoplasmic reticulum stress, J. Agr. Food Chem., 60, 11065-11070, 2012
  3. 今里孝宏,植木幸孝,平方尚之,黒田直敬,岸川直哉,矢野正生,柴 輝男,大西紀子, 井越尚子,下村弘治,足立哲夫,鈴木直季,谷山松雄,前畑英介:関節リウマチ(RA)患者の酸化度:ものさし“GAP比“の導入とその応用について-Sampled Studiesのアプローチ-.生物試料分析,35, 225-233, 2012
  4. Ozumi K, Tasaki H, Tanaka M, Harada T, Adachi T, Otsuji Y: Benefit of amlodipine/atorvastatin combination tablet in patients with hypertension, dyslipidemia and stable coronary artery disease. Ther. Res., 33, 905-909, 2012
  5. Kamiya T, Hara H, Inagaki N, Adachi T: Regulation of EC-SOD in hypoxic adipocyte, Medicicnal Chemistry and Drug Design, InTech, Published
  6. Kamiya T, Izumi M, Hara H, Adachi T: Propolis suppresses CdCl2-induced cytotoxicity of COS7 cells through the prevention of intracellular ROS accumulation, Biol. Pharm. Bull., 35, 1126-1131, 2012
  7. 藤井友和, 鈴木宏,澤柳直樹, 中村治彦, 塚本久之, 柴田孝太郎,足立哲夫, 神谷恒行: 糖尿病合併がん患者の血糖コントロールに及ぼすデキサメタゾンの影響について,日本病院薬剤師会雑誌, 48, 627-631, 2012
  8. Makino J, Kamiya T, Hara H, Adachi T: TPA induces the expression of EC-SOD in human monocytic THP-1 cells: Involvement of PKC, MEK/ERK and NOX-derived ROS, Free Radical Res., 46, 637-644, 2012 [PubMed]
  9. Adachi T, Teramachi M, Yasuda H, Kamiya T, Hara H: Contribution of p38 MAPK, NF-κB and glucocorticoid signaling pathways to ER stress-induced increase in retinal endothelial permeability, Arch. Biochem. Biophys., 520, 30-35, 2012


  1. 藤井友和, 野村賢一, 澤柳直樹, 中村治彦, 塚本久之, 足立哲夫, 神谷恒行:癌化学療法施行患者の使用薬剤を対象とした薬物相互作用の実態調査,医療薬学,37, 573-578, 2011
  2. Yamamoto A, Ashihara E, Nakagawa Y, Obayashi H, Ohta M, Hara H, Adachi T, Seno T, Kadoya M, Hamaguchi M, Ishino H, Kohno M, Maekawa T, Kawahito Y: Allograft inflammatory factor-1 is overexpressed and induces fibroblast chemotaxis in the skin of sclerodermatous GVHD in murine model. Immunol. Lett., 135, 144-50, 2011
  3. Hara H, Nakamura Y, Ninomiya M, Mochizuki R, Kamiya T, Aizenman E, Koketsu M, Adachi T: Inhibitory effects of chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives on LPS-induced NO production in microglia, Bioorg. Med. Chem., 2011 19, 5559-5568, 2011
  4. Obara A, Kamiya T, Izumi M, Hara H, Yamada H, Adachi T: Extracellular-superoxide dismutase expression in COS7 cells exposed to cadmium chloride, Biol. Pharm. Bull. ,34, 1443-1447, 2011
  5. Adachi T, Yasuda H, Nakamura S, Kamiya T, Hara H, Hara H, Ikeda T: Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase, Free Radical Res., 45, 1083-1092, 2011
  6. Adachi T, Aida K, Nishihara H, Kamiya T, Hara H: Effect of hypoxia mimetic cobalt chloride on the expression of extracellular-superoxide dismutase in retinal pericytes, Biol. Pharm. Bull., 34, 1297-1300, 2011
  7. 井越尚子,田中 明,前畑洋次郎,李 昌一,前畑英介,谷山松雄,今里孝宏,松本一成,石田紀子,中村 剛,下村弘治,柴 輝男,岸川直哉,黒田直敬,井上 穣,鈴木郁功,足立哲夫:直線回帰式法による識別検索を用いたアポEおよびTGリッチリポ蛋白に潜む病態の解明.生物試料分析,34,151-158, 2011
  8. Kamiya T, Obara A, Hara H, Inagaki N, Adachi T: ER stress inducer, thapsigargin, decreases extracellular-superoxide dismutase through MEK/ERK signaling cascades in COS7 cells, Free Radical Res., 45, 692-698, 2011
  9. Takiguchi S, Ayaori M, Uto-Kondo H, Iizuka M, Sasaki M, Komatsu T, Takase B, Adachi T, Ohsuzu F, Ikewaki K: Olmesartan improves endothelial function in hypertensive patients: link with extracellular superoxide dismutase, Hypertens. Res. 34, 686-692, 2011
  10. Fujii T, Nomura K, Sawayanagi N, Nakamura H, Iwase S, Adachi T, Kamiya T: A scheme for the safety management of cancer chemotherapy - effective use of aseptic preparation records of anticancer agents attached with pharmaceutical management information -, Jpn. J. Pharm. Health Sci., 37, 179-186, 2011
  11. Hara H, Kamiya T, Adachi T: Endoplasmic reticulum stress inducers provide protection against 6-hydroxydopamine-induced cytotoxicity. Neurochem. Int. 58, 35-43, 2011
  12. Kamiya T, Makino J, Hara H, Inagaki N, Adachi T: Extracellular-superoxide dismutase expression during monocytic differentiation of U937 cells. J. Cell. Biochem., 112, 244-255, 2011 [PubMed]
  13. 藤井友和,花村美帆,丸山康典,菅原志保,栗木玲子,中尾真隆,佐藤英和,笹尾武史,植村大志,伊藤誠一,山本倫久,神谷恒行,足立哲夫,斉藤寛子:外来がん化学療法における薬学的管理支援ワークシートを利用した薬剤師教育ツールの作成と評価.-愛知県病院薬剤師会オンコロジー研究会第5分科会の取り組み-.愛知県病院薬剤師会雑誌,38,12-21, 2011


  1. Adachi T, Yasuda H, Aida K, Kamiya T, Hara H, Hosoya K, Terasaki T,Ikeda T: Regulation of extracellular-superoxide dismutase in rat retina pericyte. Redox Rep., 15, 250-258, 2010
  2. 藤井友和,野村賢一,澤柳直樹,中村治彦,岩瀬定利,足立哲夫,神谷恒行: がん化学療法の安全管理に対する薬剤師の取り組みと評価.日本病院薬剤師会雑誌,46,1377-1380, 2010
  3. Kamiya T, Hara H, Inagaki N, Adachi T: The effect of hypoxia mimetic cobalt chloride on the expression of EC-SOD in 3T3-L1 adipocytes. Redox Rep., 15, 131-137, 2010
  4. Nakano K, Hasegawa G, Fukui M, Yamasaki M, Ishihara K, Takashima T, Kitagawa Y, Fujinami A, Ohta M, Hara H, Adachi T, Ogata M, Obayashi H, Nakamura N: Effect of pioglitazone on various parameters of insulin resistance including lipoprotein subclass according to particle size by a gel-permeation high-performance liquid chromatography in newly diagnosed patients with type 2 diabetes. Endocr. J., 2010 Feb 17 [Epub ahead of print]
  5. 中村光浩,寺町ひとみ,足立哲夫,土屋照雄: テキストマイニングによる薬学生実務実習レポートの分析.医療薬学,36, 25-30, 2010
  6. 山田晴生,北川 渡,鈴木信吉,河合浩寿,岸 泰子,上村裕子,木村行宏,宮本敢右,鈴木奈津子,前田邦博,青山龍平,山口 諭,鈴木啓介,菅 憲弘,渡辺一司,三浦直人,西川和裕,山村昌弘,今井裕一,山田裕一,足立哲夫:免疫抑制剤ミゾリビンの細胞周期・フリーラジカル産生に及ぼす影響,腎とフリーラジカル 第10集,51-55,2010
  7. 神谷哲朗,小原 彩,原 宏和,稲垣直樹,足立哲夫:小胞体ストレス下のCOS-7細胞におけるEC-SOD発現変動,腎とフリーラジカル 第10集,56-58,2010
  8. 山田晴生,北川 渡,鈴木信吉,河合浩寿,岸 泰子,上村裕子,木村行宏,宮本敢右,鈴木奈津子,前田邦博,青山龍平,山口 諭,鈴木啓介,菅 憲弘,渡辺一司, 三浦直人,西川和裕,山村昌弘,今井裕一,足立哲夫,山田裕一:血液透析患者におけるLDL結合型血清アミロイドA(SAA)蛋白の増加と栄養状態の関連,腎とフリーラジカル 第10集,176-180,2010


  1. Izuta H, Chikaraishi Y, Adachi T, Shimazawa M, Sugiyama T, Ikeda T, Hara H: Extracellular SOD and VEGF are increased in vitreous bodies from proliferative diabetic retinopathy patients. Mol. Vis., 15, 2663-2672, 2009
  2. 前畑英介,豊蔵康博,鶴﨑美徳,鈴木郁功,谷山松雄,今里孝宏,石田紀子,柴 輝男,矢野正生,井越尚子,田中 明,下村弘治,岸川直哉,黒田直敬,足立哲夫,工藤値英子,酒井香江,高橋なを子: 健診受診者の血清中酸化ストレス指標の工夫:GAP(抗酸化ギャップ)比によるメタボリックシンドロームの待ち状態の病態把握検査.医学と生物学,153, 611-619, 2009
  3. 寺町ひとみ,葛谷有美,足立哲夫,土屋照雄: 実務実習履修前学年でのコミュニケーション実習に対する評価.J. Pharmaceutical Communication, 7, 37-48, 2009
  4. Hara H, Kamiya T, Adachi T: Zinc induces expression of the BH3-only protein PUMA through p53 and ERK pathways in SH-SY5Y neuroblastoma cells. Neurochem. Res., 34, 1498-1506, 2009
  5. Adachi T, Toishi T, Wu H, Kamiya T, Hara H: Expression of extracellular superoxide dismutase during adipose differentiation in 3T3 cells. Redox Rep., 14, 34-40, 2009.
  6. Maehata Y, Lee M-C, Maehata E, Inoue M, Ishibasi F, Kudo C, Yamakado M, Shiba T, Shimomura H, Adachi T, Tsurusaki Y, Suzuki I, Hirosawa K, Imazato T, Ishida N, Kishikawa N, Kuroda N, Ikoshi N, Midorikawa Y, Ashikawa T:Pathologic background of abnormal serum amyloid A and interleukin-6 levels revealed by a piecewise linear regression model in the population of diabetic patients. Ningen Dock, 23, 7-13, 2009
  7. 足立哲夫,寺町ひとみ,原 宏和,臼井茂之,神谷哲朗,葛谷有美,土屋照雄,平野和行,永井博弌: 1年生「薬を使う薬学」PBLテュートリアルの実施とプロダクト発表に対する評価の分析.医療薬学,35, 193-199, 2009
  8. 足立哲夫,酒々井真澄,直井国子,神谷哲朗,原 宏和:アドバンストProblem-Based Learningテュートリアルの改善に向けた取り組み.薬学雑誌,129, 177-182, 2009


  1. Kamiya T, Hara H, Yamada H, Imai H, Inagaki N, Adachi T: Cobalt chloride decreases EC-SOD expression through intracellular ROS generation and p38-MAPK pathways in COS7 cells. Free Radical. Res., 42, 949-956, 2008
  2. 寺町ひとみ,足立哲夫,土屋照雄:医療心理学におけるコミュニケーション教育のためのPBLの導入とその評価.J. Pharmaceutical Communication,6, 13-22, 2008
  3. 酒井英二,寺町ひとみ,西田弘之,足立哲夫:早期体験学習としての救命講習並びに福祉体験学習の実施とその評価.薬学雑誌,128, 1227-1233,2008
  4. Kamezaki F, Yamashita K, Tasaki H, Kume N, Mitsuoka H, Kita T, Adachi T, Otsuji Y: Serum soluble lectin-like low-density lipoprotein receptor-1 correlates with oxidative stress markers in stable coronary artery disease. Int. J. Cardiol., 2008 Mar 24 [Epub ahead of print]
  5. Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, Adachi T, Obayashi H, Yoshikawa T: Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Res., 28, 137-143, 2008
  6. Maehata E, Maehata Y, Lee M-C, Kudo C, Takashiba S, Shimomura H, Yamakado M, Yano M, Shiba T, Hatakeyama I, Inoue M, Kouka K, Adachi T, Kishikawa N, Kuroda N, Sugimoto S, Watanabe H, Koga K, Ikoshi N, Shimizu K: Evaluation of immunoglobulin G antibody titer measurement in the simplified test for multiple bacteial infection in periodontal disease based on self-sampling of fingertip capillary blood -Focusing on Porphyromonas gingivalis antigen-. Ningen Dock, 22, 35-41, 2008
  7. Oyagi A, Oida Y, Hara H, Izuta H, Matsunaga N, Shimazawa M, Adachi T, Hara H: Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease. Brain Res., 1214, 169-176, 2008
  8. 寺町ひとみ,中村光浩,高島英滋,窪田傑文,足立哲夫,土屋照雄:4回生における病院実務実習の満足度調査から見えてきた改善点.医療薬学,34, 374-380, 2008
  9. 足立哲夫,酒々井真澄,直井国子,神谷哲朗,原 宏和:アドバンストPBLテュートリアルの実施とプロダクト発表に対する評価の分析.医療薬学,34, 311-319, 2008
  10. Kamezaki F, Tasaki H, Yamashita K, Tsutsui M, Koide S, Nakata S, Tanimoto A, Okazaki M, Sasaguri Y, Adachi T, Otsuji Y: Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats. Am. J. Respir. Crit. Care Med., 177, 219-226, 2008
  11. 足立哲夫,山田晴生,神谷哲朗,登石泰介,原 宏和,今井裕一:低酸素状態下でのCOS-7細胞におけるextracellular- superoxide dismutaseの発現.腎とフリーラジカル 第9集,64-66,2008
  12. 山田晴生,山田裕一,足立哲夫,宮本敢右,木村行宏,鹿島悠佳理,竹沢有美子,前田邦博,水野奈津子,青山龍平,森 由貴,若松 亮,山口 諭,菅 憲弘,渡辺一司,北川 渡,三浦直人,西川和裕,普天間新生,今井裕一:培養平滑筋細胞のextracellular-superoxide dismutase産生,腎とフリーラジカル 第9集,67-71,2008
  13. 山田晴生,足立哲夫,山田裕一,宮本敢右,木村行宏,鹿島悠佳理,竹沢有美子,前田邦博,水野奈津子,青山龍平,森 由貴,若松 亮,山口 諭,菅 憲弘,渡辺一司,北川 渡,三浦直人,西川和裕,普天間新生,今井裕一:腹腔内extracellular-superoxide dismutase産生誘導,腎とフリーラジカル 第9集,72-76,2008