一般論文
IF (Impact Factor) : 2008

＜2004　　2004　　2005　　2006　　2007　　2008　　2009　　2010　　2011　　2012　　2013　　2014


＜2004
1.Saito T., Fukuda T., Tajima S., Sukamoto T., Yamashita A., Kanazawa T., Morimoto Y., Shimohara K., Nishimura N., Yokota K., Ikegami A., Hara H. and Ito K.
General pharmacology of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate.
Arzneim. -Forch./Drg Res. (IF: 0.713), 38, 267-272, 1988.

2.Ikegami A., Maeda A., Hara H., Sukamoto T., Yamashita A. and Ito K.
Effect of trazodone (KB-831) and its metabolites on brain monoamines in rat.
Folia Pharmacol. Japon 93, 145-154, 1989.

3.Hara H. and Kogure K.
Prevention of hippocampus neuronal damage in ischemic gerbils by a novel lipid peroxidation inhibitor (Quinazoline derivative).
J. Pharmacol. Exp. Ther. (IF: 4.309), 255, 906-913, 1990.

4.Hara H., Kato H. and Kogure K.
Protective effect of α-tocopherol on ischemic neuronal damage in the gerbil hippocampus.
Brain Res. (IF: 2.623), 510, 335-338, 1990.

5.Hara H., Onodera H., Yoshidomi M., Matsuda Y. and Kogure K.
Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil ahd rat.
J. Cereb. Blood Flow & Metabol. (IF: 5.741), 10, 646-653, 1990.

6.Hara H., Onodera H., Kogure K. and Akaike N.
The regional difference of neuronal susceptibility in the dentate gyrus to hypoxia.
Neurosci. Lett. (IF: 2.026), 115, 189-194, 1990.

7.Hara H., Onodera H. and Kogure K.
Protein kinase C activity in the gerbil hippocampus after transient forebrain ischemia: morphological and autoradiographic analysis using [³H]phorbol12,13-dibutyrate.
Neurosci. Lett. (IF: 2.026), 120, 120-123, 1990.

8.Hara H., Ozaki A., Yoshidomi M. and Sukamoto T.
Protective effect of KB-2796, a new calcium antagonist, on cerebral hypoxia and ischemia.
Arch. Int. Pharmacodyn., 304, 206-218, 1990.

9.Hara H., Nagasawa H. and Kogure K.
Nimodipine prevents postischemic brain damage in the early phase of focal cerebral ischemia.
Stroke (IF: 7.041), 21, 102-104, 1990.

10.Hara H., Nagasawa H. and Kogure K.
Nimodipine attenuates both ischemia-induced brain oedema and mortality in a rat novel transient middle cerebral artery occlusion model.
Acta Neurochirugica. (IF: 1.634), 51, 251-253, 1990.

11.Hara H., Onodera H., Nagasawa H. and Kogure K.
Effect of nimodipine on ischemia-induced brain edema and mortality in a novel transient middle cerebral artery occlusion model.
Jpn. J. Pharmacol. (IF: 2.408), 53, 247-253, 1990.

12.Onodera H., Hara H., Kogure K., Fukunaga K., Ohta Y. and Miyamoto E.
Ca²⁺/calmoduline-dependent protein kinase II immunoreactivity in the rat hippocampus after forebrain ischemia.
Neurosci. Lett. (IF: 2.026), 113, 134-138, 1990.

13.Hori M., Iemura R., Hara H., Ozaki A., Sukamoto T. and Ohtaka H.
Novel 4-phenoxy-2-(1-piperazinyl)quinazolines as potent anticonvulsive and antihypoxic agents.
Chem. Pharm. Bull. (IF: 1.623), 38, 681-687, 1990.

14.Hori M., Iemura R., Hara H., Ozaki A., Sukamoto T. and Ohtaka H.
Novel 4-substituted 2-piperazinylquinazolines as potent anticonvulsive and antihypoxic agents.
Chem. Pharm. Bull. (IF: 1.623), 38, 1286-1291, 1990.

15.Hara H., Kato H., Araki T., Onodera H. and Kogure K.
Involvement of lipid peroxidation and inhibitory mechanisms on ischemic neuronal damage in the gerbil hippocampus: Quantitative autoradiographic studies on second messenger and neurotransmitter systems.
Neuroscience (IF: 3.556), 42, 159-169, 1991.

16.Hara H., Onodera H., Kato H., Araki T. and Kogure K.
Autoradiographic analysis of second messenger neurotransmitter system receptors in the gerbil hippocampus following transient forebrain ischemia.
Brain Res. (IF: 2.623), 545, 87-96, 1991.

17.Hara H., Kogure K., Kato H., Ozaki A. and Sukamoto T.
Amelioration of brain edema and neuronal damage from induced focal cerebral ischemia in the rat by a potential lipid peroxidation inhibitor.
Eur. J. Pharmacol. (IF: 2.737), 197, 75-82, 1991.

18.Hara H., Onodera H., Kawagoe J. and Kogure K.
Failure of basic fibroblast growth factor to prevent postischemic neuronal damage in the rat.
Eur. J. Pharmacol. (IF: 2.737), 209, 195-198, 1991.

19.Kawagoe J., Hara H. and Kogure K.
Distribution of protein kinase C activity in the hippocampus of the gerbil and rat: Autoradiographic analysis by [³H]phorbol 12,13-dibutyrate.
J. Pharm. Pharmacol.(IF: 1.847), 43, 758-761, 1991.

20.Hori M., Iemura R., Hara H., Sukamoto T., Ito K. and Ohtaka H.
Potential nootropic agents, 4-alkoxy-2-(1-piperazinyl)-quinazoline derivatives.
Chem. Pharm. Bull. (IF: 1.623), 39, 367-371, 1991.

21.Kato H., Araki T., Hara H. and Kogure K.
Sequential changes in muscarinic acetylcholine, adenosine A1 and calcium antagonist binding sites in the gerbil hippocampus following repeated brief ischemia.
Brain Res. (IF: 2.623), 553, 33-38, 1991.

22.Yamasaki Y., Kogure K., Hara H., Ban H. and Akaike N.
The possible involvement of tetrodotoxin-sensitive ion channels on ischemic neuronal damage in the rat hippocampus.
Neurosci. Lett. (IF: 2.026), 121, 251-254, 1991.

23.Araki T., Kato H., Hara H. and Kogure T.
Postischemic alteration of [³H]forskolin binding sites in selectively vulnerable areas: an autoradiographic study of gerbil brain.
Neurosci. Lett. (IF: 2.026), 125, 159-162, 1991.

24.Kato H., Araki T., Hara H. and Kogure K.
Autoradiographic analysis of second-messenger systems in the gerbil hippocampus following repeated brief ischemic insults.
Brain Res. Bull. (IF: 2.281), 27, 759-765, 1991.

25.Hara H., Onodera H., Kato H. and Kogure K.
Effects of aging on signal transmission and transduction systems in the gerbil brain: Morphological and autoradiographic study.
Neuroscience (IF: 3.556), 46, 475-488, 1992.

26.Hara H., Kato H., Onodera H., Kawagoe J. and Kogure K.
Redional variations in particulate cyclic AMP dependent-protein kinase bindiing activity in the gerbil hippocampus following transient forebrain ischemia by [³H]cyclic AMP binding.
Brain Res. (IF: 2.623), 574, 26-32, 1992.

27.Hara H., Sukamoto T., Abe K., Tatumi Y., Saito Y., Ohtaka H. and Tsukamoto G.
Effects of baicalein and α-tocopherol on lipid peroxidation, free radical scavenging activity and 12-o-tetradecanoylphorbol acetate-induced ear edema.
Eur. J. Pharmacol. (IF: 2.737), 221, 193-198, 1992.

28.Hara H., Onodera H. and Kogure K.
Effects of hyperthermia on the effectiveness of MK-801 treatment in the gerbil hippocampus following transient forebrain ischemia.
Brain Res. Bull. (IF: 2.281), 29, 659-665, 1992.

29.Ikegami A., Ozaki A., Hara H., Sukamoto T., Yamashita A. and Ito K.
Neurochemical investigation of a new diphenylpiperazine calcium antagonist, KB-2796, on the central dopaminergic system in rats.
Jpn. J. Pharmacol. (IF: 2.408), 58, 399-405, 1992.

30.Araki T., Kato H., Hara H. and Kogure K.
Postischemic binding of [³H]phorbol 12,13-dibutyrate and [³H]inositol 1,4,5-trisphosphate in the gerbil brain: an autoradiographic study.
Neuroscience (IF: 3.556), 46, 973-980, 1992.

31.Yamamoto K., Nishimura N., Yoshidomi M., Hara H., Harada K., Iwamoto T., Harada Y., Ogata T. and Sukamoto T.
General pharmacological studies on naftopidil (KT-611) and its main metabolites.
The Clinical Report, 26, 229-246, 1992.

32.Hara H., Harada K. and Sukamoto T.
Chronological atrophy after transient middle cerebral artery occlusion in rats.
Brain Res. (IF: 2.623), 618, 251-260, 1993.

33.Hara H., Yokota K., Shimazawa M. and Sukamoto T.
Effect of KB-2796, a new diphenylpiperazine Ca²⁺ antagonist, on glutamate-induced neurotoxicity in rat hippocampal primary cell cultures.
Jpn. J. Pharmacol. (IF: 2.408), 61, 361-365, 1993.

34.Akaike N., Ishibashi H., Hara H., Oyama Y. and Ueda T.
Effect of KB-2796, a new diphenylpiperazine Ca²⁺ antagonist, on voltage-dependent Ca²⁺ currents and oxidative metabolism in dissociated mammalian CNS neurons.
Brain Res. (IF: 2.623), 619, 263-270, 1993.

35.Morita T., Iwamoto T., Harada K., Hara H., Sukamoto T., Ito K. and Nurimoto S.
Effects of 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl) piperazine dihydochloride (KB-2796) on cerebral circulation in dogs.
Pharmacometrics, 45, 473-481, 1993.

36.Yamashita A., Ozaki A., Ikegami A., Hayashi A., Hara H., Sukamoto T. and Ito K.
Effects of a new diphenylpiperazine calcium antagonist, KB-2796, on cerebral ischemic neuronal damages in rats.
Gen. Pharmacol. 24, 1473-1480, 1993.

37.Morita T., Yamashita A., Morimoto Y., Saito T., Nishimura N., Yokota K., Hara H., Ikegami K., Harada A., Imamura A., Sukamoto T., Ito K. and Nurimoto S.
General pharmacology of a novel Ca²⁺ antagonist, 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796).
Pharmacometrics, 46, 243-260, 1993.

38.Hara H., Tanaka K., Harada Y. and Sukamoto T.
Sigma receptor-mediated effects of a new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric alkaline secreation in rats.
J. Pharmacol. Exp. Ther. (IF: 4.309), 269, 799-805, 1994.

39.Harada Y., Hara H. and Sukamoto T.
Characterization of specific (+)-[³H]N-allylnormetazocine and [³H]1,3-di(2-tolyl)guanidine binding sites in porcine gastric fundic mucosa.
J. Pharmacol. Exp. Ther. (IF: 4.309), 269, 905-910, 1994.

40.Harada Y., Hara H. and Sukamotoo T.
Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain.
Eur. J. Pharmacol. (IF: 2.737), 256, 321-328, 1994.

41.Harada Y., Hara. and Sukamoto T.
Binding properties of KB-5492, a novel anti-ulcer agent, at sigma receptors in porcine gastric fundic mucosa.
Eur. J. Pharmacol. (IF: 2.737), 261, 91-96, 1994.

42.Fujishima Y., Hara H., Shimazawa M., Yokota K. and Sukamoto T.
The effects of novel Ca²⁺ channel blocker, KB-2796, on 5-HT-induced responses.
Folia Pharmacol. Jpn., 104, 19-29, 1994.

43.Watano T., Tanaka K., Hara H. and Sukamoto T.
Analgesic effects of an antidepressant, trazodone hydrochloride (Reslin).
J. Med. Pharmaceutical Sci., 32, 45-53, 1994.

44.Kato H., Araki T., Hara H. and Kogure K.
Regional changes in [³H]inositol 1,4,5-triphosphate binding in the gerbil brain following repeated sublethal ischemia.
Brain Res. Bull. (IF: 2.281), 33, 465-468, 1994.

45.Morimoto Y., Oshima S., Hara H. and Sukamoto T.
Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro.
Jpn. J. Pharmacol. (IF: 2.408), 64, 41-47, 1994.

46.Morimoto Y., Shimohara K., Oshima S., Hara H. and Sukamoto T.
Effects of KB-5492, a new anti-ulser agent with a selective affinity for the sigma-receptor, on aspirin-induced distribution of the rat gastric mucosal barrier.
Jpn. J. Pharmacol (IF: 2.408)., 64, 49-55, 1994.

47.Morimoto Y., Shimohara K., Tanaka K., Hara H. and Sukamoto T.
4-Methoxyphenyl 4-(3,4,5-trimethoxybenzyl) -1-piperazineacetate monofumarate monohydrate (KB-5492), a new anti-ulcer agent with a selective affinity for the sigma receptor,prevents cysteamine-induced duodenal ulcers in rats by a mechanism different from that of cimetidine.
Jpn. J. Pharmacol. (IF: 2.408), 64, 221-224, 1994.

48.Shimazawa M., Hara H., Watano T. and Sukamoto T.
Effects of Ca²⁺ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats.
Br. J. Pharmacol. (IF: 4.902), 115, 1359-1368, 1995.

49.Watano T., Hara H., Yamashita A. and Sukamoto T.
Effects of Dokkatsu-kakkon-to on the blood flow in the femoral skeletal muscle in anesthetized rats.
J. Traditional Med., 12, 154-159, 1995.

50.Hara H., Huang P. L., Panahian N., Fishman M. C. and Moskowitz M. A.
Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion.
J. Cereb. Blood Flow & Metabol. (IF: 5.741), 16, 605-611, 1996.

51.Hara H., Waeber C., Huang P. L., Fujii M., Fishman M. C. and Moskowitz M. A.
Brain distribution of nitric oxide synthase in neuronal or endothelial nitric oxide synthase mutant mice using [³H]L-N^G-nitro-arginice autoradiography.
Neuroscience (IF: 3.556), 75, 881-890, 1996.

52.Shimazawa M. and Hara H.
An experimental model of migraine with aura: cortical hypoperfusion following spreading depression in the awake and freely moving rat.
Clin. Exp. Pharmacol. Physiol. (IF: 2.196), 23, 890-892, 1996.

53.Lo E., Hara H., Rogowska J., Trocha M., Pierce A. R., Huang P. L., Fishman M. V., Wolf G. L. and Moskowitz M. A.
Temporal correlation mappping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression.
Stroke (IF: 7.041), 27, 1381-1385, 1996.

54.Yamaguchi T., Hara H., Harada Y., sakita Y. and Sukamoto T.
The effects of naftopidil on blood pressure, heart rate and plasma norepinephrine level in freely moving rabbits.
Jpn. Pharmacological.Ther., 24, 49-53, 1996.

55.Meng W., Ma J., Ayata C., Hara H., Huang P. L., Fishman M. C. and Moskowitz M. A.
Ach dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms.
Am J. Physiol.(IF: 0.831), 271, H1145-H1150, 1996.

56.Hara H., Friedlander R. M., Gagliardini V., Ayata C., Fink K., Huang Z., Shimizu-Sasamata M., Yuan J. and Moskowitz M. A.
Effects of inhibition of the ICE family proteases on ischemic and excitotoxic neuronal damage.
Proc. Natl. Acd. Sci., U.S.A. (IF: 9.64), 94, 2007-2012, 1997.

57.Hara H., Ayata C., Huang P. L., Waeber C., Ayata G., Fujii M. and Moskowitz M. A.
[³H]L-NG-Nitro-arginine binding after transient focal ischemia and NMDA-induced excitotoxicity in type I and type III nitric oxide synthase null mice.
J. Cereb. Blood Flow & Metabol. (IF: 5.741), 17, 515-526, 1997.

58.Hara H., Ayata G., Huang P. L. and Moskowitz M. A.
Alteration of protein kinase C activity binding after transient focal cerebral ischemia in mice using in vitro [³H]phorbol-12,13-dibutyrate binding autoradiography.
Brain Res. (IF: 2.623), 774, 69-76, 1997.

59.Hara H., Fink K., Endres M., Friedlander R. M., Gagliardini V., Yuan J. and Moskowitz M. A.
Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein.
J. Cereb. Blood Flow & Metabol. (IF: 5.741), 17, 370-375, 1997.

60.Zaharachuck G., Hara H., Huang P. L., Fishman M. C., Moskowitz M. A., Jenkins B. G. and Rosen B. R.
Neuronal nitric oxide synthase mutant mice show smaller infarcts and attenuated apparent diffusion coefficient changes in the peri-infarct zone during focal cerebral ischemia.
Mag. Reson. Imag. (IF: 1.871), 37, 170-175, 1997.

61.Fujii M., Hara H., Meng W., Vonsattel J. P., Huang Z. and Moskowitz M. A.
Strain-related differences in susceptibility to transient forebrain ischemia in SV-129 and C57black/6 mice.
Stroke (IF: 7.041), 28, 1805-1811, 1997.

62.Watano T., Hara H. and Sukamoto T.
Inhibitory effect of lomerizine, a diphenylpiperazine Ca²⁺-channel blocker, on Ba2+ current through voltage-gated Ca²⁺ channels in PC12 calls.
Jpn. J. Pharmacol. (IF: 2.408), 75, 209-213, 1997.

63.Friedlander R. M., Gagliardini V., Hara H., Fink K. B., Li W., MacDonald G., Fishman M. C., Greenberg A. H., Moskowitz M. A. and Yuan J.
Expression of a dominant negative mutant of ICE in transgenic mice prevents neuronal cell death induced by trophic factotr withdrawal and ischemic brain injury.
J. Exp. Med. (IF: 15.219), 185, 933-940, 1997.

64.Ayata C., Ayata G., Hara H., Mattews R. T., Beal M. F., Ferrante R. J., Endres M., Kim A., Christie R. H., Waeber C., Huang P. L., Hyman B. T. and Moskowitz M. A.
Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.
J Neurosci. (IF: 7.506), 17, 6908-6917, 1997.

65.Ofuji K., Hara H., Sukamoto T. and Yamashita S.
Effects of an antidiarrhoeica containing an extract from Geranium Herb on astringent action and short-circuit current asross jejunal mucosa.
Folia Pharmacol. Japon, 111, 265-275, 1998.

66.Bergeron L., Perez G. I., MacDonald G., Shi L., Sun Y., Jurisicova A., Varmuza S., Latham K. E., Flaws J. A., Salter J. C., Hara H., Moskowitz M. A., Li E., Greenberg A., Tilly J. L. and Yuan J.
Defects in regulation of apoptosis in caspase-2-deficient mice.
Genes and Development (IF: 13.623), 12, 1304-1314, 1998.

67.Hara H., Shimazawa M., Hashimoto M. and Sukamoto T.
Anti-migraine effects of lomerizine.
Folia Pharmacol. Japon, 112, 138-142, 1998.

68.Shimazawa M., Sugiyama T., Azuma I., Araie M., Iwakura Y., Watari M., Sakai T. and Hara H.
Effects of lomerizine, a new Ca²⁺ channel blocker, on the microcirculation of optic nerve head in conscious rabbits using a laser speckle technique.
Exp. Eye Res. (IF: 3.259), 69, 185-193, 1999.

69.Hara H., Shimazawa M., Sasaoka M., Yamada C., Iwakura Y., Sakai T., Maeda Y., YamaguchiT., Sukamoto T. and Hashimoto M.
Selective effects of lomerizine, a novel diphenylmethylpiperazine Ca²⁺ channel blocker, on cerebral blood flow in rats and dogs.
Clin. Exp. Pharmacol. Physiol.(IF: 2.196), 26, 870-876, 1999.

70.Toriu N., Akaike A., Yasuyoshi H., Zhang S., Kashii S., Honda Y., Shimazawa M. and Hara H.
Lomerizine, Ca²⁺ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rrat retina.
Exp. Eye Res. (IF: 3.259), 70, 475-484, 2000.

71.Shibata M., Hisahara S., Hara H., Yamawaki T., Fukuuchi Y., Yuan J., Okano H. and Miura M.
Caspases determine the vulnerability of oligodendrocytes in the ischemic brain.
J. Clin. Invest. (IF: 16.559), 106, 643-653, 2000.

72.Kang S., Wang S., Hara H., Peterson E. P., Namura S., Amin-Hanjani S., Huang Z., Srinivasan A., Tomaselli K. J., Thornberry N. A., Moskowitz M. A. and Yuan J.
Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.
J. Cell Biol. (IF: 9.12), 149, 613-622, 2000.

73.Toriu N., Sasaoka M., Shimazawa M., Sugiyama T. and Hara H.
Effects of Lomerizine, a novel Ca²⁺ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits.
J. Ocul. Pharmacol. Ther. (IF: 1.37), 17,131-149, 2001.

74.Ota T., Hara H. and Miyawaki N.
Quantitative analysis of retinal ganglion cell damage following optic nerve axotomy in rats.
Jpn. J. Ocular Pharmacol., 15, 29-30, 2001.

75.Sugiyama T., Hara H., Oku H., Nakatsuji S., Okuno T., Sasaoka M., Ota T. and Ikeda T.
Optic cup enlargement followed by reduced optic nerve head circulation after optic nerve stimulation.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 42, 2843-2848, 2001.

76.Kido N., Inatani M., Honjo M., Yoneda S., Hara H., Miyawaki N., Honda Y. and Tanihara H.
Dual effects of interleukin-1β on N-methyl-D-aspartate-induced retinal neuronal death in rat eyes.
Brain Res. (IF: 2.623), 910, 153-162, 2001.

77.Yoneda S., Tanihara H., Kido N., Honda Y., Goto W., Hara H. and Miyawaki N.
Interleukin-1β mediates ischemic injury in the rat retina.
Exp. Eye Res. (IF: 3.259), 73, 661-667, 2001.

78.Ota T., Hara H. and Miyawaki N.
Brain-derived neurotrophic factor inhibits changes in soma-size of retinal ganglion cells following optic nerve axotomy in rats.
J. Ocul. Pharmacol. Ther. (IF: 1.37), 18, 241-249, 2002.

79.Goto W., Ota T., Morikawa N., Otori Y., Hara H., Kawazu K., Miyawaki N. and Tano Y.
Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina.
Brain Res. (IF: 2.623), 958, 10-19, 2002.

80.Yoneda S., Tanaka E., Goto W., Ota T. and Hara H.
Topiramate reduces excitotoxic and ischemic injury in the rat retina.
Brain Res. (IF: 2.623), 967, 257-266, 2003.

81.Akaishi T., Shimazaki A., Matsugi T., Miyawaki N., Hara H. and Kuwayama Y.
Effects of ocular hypotensive agents on the circadian rhythm in itraocular pressure in rabbits as measured by teremetry.
Nippon Ganka Gakkai Zasshi, 107, 513-518, 2003.

82.Nakajima T., Matsugi T., Goto W., Kageyama M., Mori N., Matsumura Y. and Hara H.
New fluoroprostaglandin F_2α derivatives with prostanoid FP-receptor agonistic acivity as potent ocular-hypotensive agents.
Biol. Pharm. Bull. (IF: 1.849), 26, 1691-1695, 2003.

ページ頭に戻る

2004
83-1.Ichikawa M., Okada Y., Hara H., Ishii K. and Araie M.
Effects of topically bunazosin, an α1-adrenoceptor antagonist, on constrictions induced by phenylephline and ET-1 in rabbit retinal arteries.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 45, 4041-4048, 2004.

84-2.Taniguchi T., Shimazawa M. and Hara H.
Alterrations in neurofilament light in optic nerve in rat kainate and monkey ocular hypertension models.
Brain Res. (IF: 2.623), 1013, 241-248, 2004.

85-3.Yamamoto R., Yoneda S. and Hara H.
Neuroprotective effects of β-secretase inhibitors against rat retinal ganglion cell death.
Neurosci. Lett. (IF: 2.026), 370, 61-64, 2004.

86-4.Takagi Y., Nakajima T., Shimazaki A., Kageyama M., Matsugi T., Matsumura Y., Gabelt B. T., Kaufman P. L. and Hara H.
Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug.
Exp. Eye Res. (IF: 3.259), 78, 767-776, 2004.

87-5.Okada Y., Ichikawa M., Ishii K. and Hara H.
Effects of topically instilled bunazosin hydrochloride and other ocular hypotensive drugs on endothelin-1-induced constriction in rabbit retinal arteries.
Jpn. J. Ophthalmol. (IF: 0.667), 48, 465-469, 2004.

88-6.Akashi T., Takagi Y., Matsugi T., Ishida N., Hara H. and Kashiwagi K.
Effects of bunazosin hydrochloride on ciliary muscle constriction and matrix metalloproteinase activities.
J. Glaucoma (IF: 2.078), 13, 312-318, 2004.

89-7.Goto W., Ichikawa M., Tanaka E., Hara H. and Araie M.
Bunazosin hydrochloride reduces glutamate-induced neurotoxicity in rat primary retinal cultures.
Brain Res. (IF: 2.623), 1003, 130-137, 2004.

90-8.Shimazaki A., Suhara H., Ichikawa M., Matsugi T., Konomi K., Takagi Y., Hara H., Rao P. O. and Epstein D. L.
New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells.
Biol. Pharm. Bull. (IF: 1.849), 27, 846-850, 2004.

91-9.Shimazaki A., Ichikawa M., Rao P. O., Kirihara T., Konomi K., Epstein D. L. and Hara H.
Effects of the new ethacrynic acid derivative SA9000 on intraocular pressure in cats and monkeys.
Biol. Pharm. Bull. (IF: 1.849), 27, 1019-1024, 2004.

92-10.Matsumura Y., Mori N., Nakano T., Sasakura H., Matsugi T., Hara H. and Morizawa Y.
Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168: a novel 15-deoxy15,15,-difluoroprostaglandin F_2α derivative.
Tetrahedron Lett. (IF: 2.538), 45, 1527-1529, 2004.

93-11.Taniguchi T., Shimazawa M. and Hara H.
Change in phosphorylated neurofilament heavy chain in the rat kainite-induced optic nerve damage.
J. Eye 21, 1101-1104, 2004.

94-12.Matsugi T., Takagi Y., Nakajima T., Goto W., Kageyama M., Mori N., Matsunuma Y. and Hara H.
Prostanoid FP-receptor agonistic activities and ocular hypotensive effects of 15,15-difluoro prostaglandin F_2α derivatives.
Jpn. J. Ocular Pharmacol., 18, 74-76, 2004.

95-13.Oku H., Goto W., Okuno T., Kobayashi T., Sugiyama T., Ota T., Yoneda S., Hara H. and Ikeda T.
Effects of poly(ADP-ribose) polymerase inhibitor on NMDA-induced retinal injury.
Curr. Eye Res. (IF: 1.519), 29, 403-411, 2004.

96-14.Oku H.,Goto W., Kobayashi T., Okuno T., Hirano M., Sugiyama T., Yoneda S., Hara H. and Ikeda T.
Adenosine protects cultured retinal neurons agonist NMDA-induced cell death through A1 receptors.
Curr. Eye Res. (IF: 1.519), 29, 449-488, 2004.

ページ頭に戻る

2005
97-1.Yoneda S., Hara H., Hirata A., Fukushima M., Inomata Y. and Tanihara H.
Vitreous fluid levels of β-amyloid(1-42) and Tau in patients with retinal diseases.
Jpn. J. Ophthalmol. (IF: 0.667), 49, 106-108, 2005.

98-2.Morimoto N., Shimazawa M., Yamashita T., Nagai H. and Hara H.
Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage.
Brain Res. (IF: 2.623), 1044, 8-15, 2005.

99-3.Yoneda S., Shimazawa M., Kato M., Nonoyama A., Torii Y., Nishino H., Sugimoto N., Kozaki S. and Hara H.
Comparison of the therapeutic indexes of different molecular forms of botulinum toxin type A.
Eur. J. Pharmacol. (IF: 2.737), 508, 223-229, 2005.

100-4.Shimazawa M., Miyake Y., Yamaguchi T., Yokota K., Sukamoto T. and Hara H.
Effect of pamicogrel, a new antiplatelet drug, on the progression of sodium laurate-induced arterial occlusive in guinea pigs.
Jpn. J. Thromb. Hemost., 16, 212-221, 2005.

101-5.Sasaoka M., Hara H. and Nakamura K.
Comparison between monkey and human visual fields using a personal computer system.
Behavioral Brain Res. (IF: 3.171), 161, 18-30, 2005.

102-6. Shimazawa M., Chikamatsu S., Morimoto N., Mishima S., Nagai H. and Hara H.
Neuroprotection by Brazilian green propolis in vitro and in vivo ishemic neuronal damage.
eCAM (IF: 2.535), 2, 201-207, 2005.

103-7.Taniguchi T., Shimazawa M., Araie M., Tomita G., Sasaoka M., Kitazawa Y. and Hara H.
Optic disc topographic parameters measured in the normral cynomolgus monkey by confocal scanning laser tomography.
Br. J. Ophthalmol. (IF: 2.859), 89, 1058-1062, 2005.

104-8.Shimazawa M., Yamashita T., Agarwal N. and Hara H.
Neuroprotective effects minocycline against in vitro and in vivo retinal ganglion cell damage.
Brain Res. (IF: 2.623), 1053, 185-194, 2005.

105-9.Akaishi T., Ishida N., Shimazaki A., Hara H. and Kuwayama Y.
Continuous monitoring of circadian variations in intraocular pressure by telemetry system throughout 12 weeks' treatment with timolol maleate in rabbits.
J. Ocul. Pharmacol. Ther. (IF: 1.37), 21, 436-444, 2005.

106-10.Shimazawa M., Kondo K., Hara H., Nakashima M. and Umemura K.
Sulfatides, L-and P-selectin ligands, exacerbate the intimal hyperplasia occurring after endothelial injury.
Eur. J. Pharmacol. (IF: 2.737), 520, 118-126, 2005.

107-11.Shimazawa M., Watanabe S., Kondo K., Hara H.., Nakashima M. and Umemura K.
Neutrophil accumulation promotes intimal hyperplasia after photochemically induced arterial injury in mice.
Eur. J. Pharmacol. (IF: 2.737), 520, 156-163, 2005.

ページ頭に戻る

2006
108-1.Tsuruma K., Nakagawa T., Morimoto N., Minami M., Hara H., Uehara T. and Nomura Y.
Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.
J. Biol. Chem. (IF: 5.52), 281, 11397-11404, 2006.

109-2.Komine-Kobayashi M., Zhang N., Liu M., Tanaka R., Hara H., Osaka A., Mochizuki H., Mizuno Y. and Urabe T.
Neuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of mice.
J. Cereb. Blood Flow & Metabol. (IF: 5.741), 26, 402-413, 2006.

110-3.Sasaoka M., Taniguchi T., Shimazawa M., Ishida N., Shimazaki A. and Hara H.
Intravitreal injection of endotheline-1 caused optic nerve damage following to ocular hypoperfusion in rabbits.
Exp. Eye Res. (IF: 3.259), 82, 427-440, 2006.

111-4.Taniguchi T., Shimazawa M., Sasaoka M. and Hara H.
Endothelin-1 impairs retrograde axonal transport and leads to axonal injury in rat optic nerve.
Curr. Neurovasc. Res. (IF: 3.571), 3, 81-88, 2006.

112-5.Shimazawa M., Taniguchi T., Sasaoka M. and Hara H.
Nerve fiber layer measurememt using scanning laser polarimetry with fixed corneal compensator in normal cycnomolgus monkey eyes.
Ophthalmic Res. (IF: 1.317), 38, 1-7, 2006.

113-6.Shimazawa M., Tomita G., Taniguchi T., Sasaoka M., Hara H., Kitazawa Y. and Araie M.
Morphometric evaluation of changes with time in optic disc structure and thickness of retinal nerve fibre layer in chronic ocular hypertensive monkeys.
Exp. Eye Res. (IF: 3.259), 82, 427-440, 2006.

114-7.Inokuchi Y., Shimazawa M., Nakajima Y., Suemori S., Mishima S. and Hara H.
Brazilian green propolis protects against retinal damage in vitro and in vivo.
eCAM (IF: 2.535), 3, 71-77, 2006.

115-8.Oida Y., Kitaichi K., Nakayama H., Ito Y., Fujimoto Y., Shimazawa M., Nagai H. and Hara H.
Rifampicin attenuates the MPTP-induced neurotoxicity in mouse brain.
Brain Res. (IF: 2.623), 1082, 196-204, 2006.

116-9.Hara H., Oh-hashi K., Yoneda S., Shimazawa M., Inatani M., Tanihara H. and Kiuchi K.
Elevated neprilysin activity in vitreous of patients with proliferative diabetic retinopathy.
Mol. Vision (IF: 2.464), 12, 977-982, 2006.

117-10.Suemori S., Shimazawa M., Kawase K., Satoh M., Nagase H., Yamamoto T. and Hara H.
Metallothionein, an endogeneous antioxidant, protects against retinal neuron damage in mice.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 47, 3975-3982, 2006.

118-11.Wakida K., Morimoto N., Shimazawa M., Hozumi I., Nagase H., Inuzuka T. and Hara H.
Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2.
Brain Res. (IF: 2.623), 1116, 187-193, 2006.

119-12.Ito Y., Shimazawa M., Akao Y., Nakajima Y., Seki N., Nozawa Y. and Hara H.
Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo.
J. Pharmacol. Sci. (IF: 2.150), 102, 196-204, 2006.

120-13.Shimazawa M. amd Hara H.
Inhibitor of double stranded RNA-dependent proteinkinase protects against cell damage induced by ER stress.
Neurosci. Lett. (IF: 2.026), 409, 192-195, 2006.

ページ頭に戻る

2007
121-1.Nakajima Y., Shimazawa M., Mishima S. and Hara H.
Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects vis antioxidant actions.
Life Sci. (IF: 2.583), 80, 370-377, 2007.

122-2.Chikaraishi Y., Shimazawa M. and Hara H.
New quantitative analysis, using high-resolution images, of oxygen-induced retinal neovascularization in mice.
Exp. Eye Res. (IF: 3.259), 84, 529-536, 2007.

123-3.Shimazawa M., Inokuchi Y., Ito Y., Murata H., Aihara M., Miura M., Araie M. and Hara H.
Involvememt of ER stress in retinal cell death.
Mol. Vision (IF: 2.464), 13, 578-587, 2007.

124-4.Kondo S., Saito A., Hino S., Murakami T., Ogata M., Kanemoto S., Nara S., Yamashita A., Hara H. and Imaizumi K.
BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of ER stress transducer.
Mol. Cell. Biol. (IF: 5.942), 27, 1716-1729, 2007.

125-5.Shimazawa M., Ito Y., Inokuchi Y. and Hara H.
Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 48, 3729-3736, 2007.

126-6.Yamashita K., Kotani Y., Nakajima Y., Shimazawa M., Yoshimura S., Nakashima S., Iwama T. and Hara H.
Fasudil, a Rho kinase(ROCK) inhibitor, protects against ischemic neuronai damage in vitro and in vivo by acting directly on neurons.
Brain Res. (IF: 2.623), 1154, 215-224, 2007.

127-7.Morimoto N., Oida Y., Shimazawa M., Miura M., Kudo T., Imaizumi K. and Hara H.
Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice.
Neuroscience (IF: 3.556), 147, 957-967, 2007.

128-8.Wakida K., Shimazawa M., Satoh M., Nagase H., Imaizumi T. and Hara H.
Neuroprotective effect of erythropoietin, and role of metallothionei-1 and -2, in permanent focal cerebral ischemia.
Neuroscience (IF: 3.556), 148, 105-114, 2007.

129-9.Kotani Y., Morimoto N., Oida Y., Tamura Y., Tamura S., Inoue T., Shimazawa M., Yoshimura S., Iwama T. and Hara H.
Prevention of in vitro and in vivo acute ischemic neuronal damage by (2S)-1-(4-Amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl) phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate (SUN N8075), a novel neuroprotective agent with antioxidant properties.
Neuroscience (IF: 3.556), 149, 779-788, 2007.

ページ頭に戻る

2008
130-1.Chikaraishi Y., Matsunaga N., Shimazawa M. and Hara H.
Rifampicin inhibits the retinal neovascularization in vitro and in vivo.
Exp. Eye Res. (IF: 3.259), 86, 131-137, 2008.

131-2.Oida Y., Shimazawa M., Imaizumi K. and Hara H.
Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil.
Neuroscience (IF: 3.556), 151, 111-119, 2008.

132-3.Kudo T., Kanemoto S., Hara H., Morimoto N., Morihara T., Kimura R., Tabira T., Imaizumi K and Takeda M.
A molecular chaperone inducer protects neurons from ER stress.
Cell Death and Differentiation (IF: 7.548), 15, 364-375, 2008.

133-4.Matsunaga N., Shimazawa M., Otsubo K. and Hara H.
Phosphatidylinositol inhibits vascular endothelial growth factor-A-induced migration of human umbilical vein endothelial cells.
J. Pharmacol. Sci. (IF: 2.150), 106, 128-135, 2008.

134-5.Kotani Y., Nakajima Y., Hasegawa T., Satoh M., Nagase H., Shimazawa M., Yoshimura S., Iwama T. and Hara H.
Propofol exerts greater neuroprotection with disodium edetate than without it.
J. Cereb. Blood Flow & Metabol. (IF: 5.741), 28, 354-366, 2008.

135-6.Hara H., Ise Y., Morimoto N., Shimazawa M., Ichihashi K., Ohyama M. and Iinuma M.
Laxative effect of agarwood leaves and its mechanism.
Biosci. Biotech. Biochem. (IF: 1.39), 72, 335-345, 2008.

136-7.Oyagi A., Oida Y., Hara H., Izuta H., Shimazawa M., Matsunaga N., Adachi T. and Hara H.
Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease.
Brain Res. (IF: 2.623), 1214, 169-176, 2008.

137-8.Ito Y., Shimazawa M., Inokuchi Y., Fukumitsu H., Furukawa S., Araie M. and Hara H.
Degenerative alterations in the visual pathway after NMDA-induced retinal damage in mice.
Brain Res. (IF: 2.623), 1212, 89-101, 2008.

138-9.Yamamoto T., Shibata N., Takashima M., Nakamura S., Toru T., Matsunaga N. and Hara H.
Enzymatic resolution and evaluation of enantiomers of cis-5'-hydroxythalidomide.
Org. Biomol. Chem. (IF: 3.550), 6, 1540-1543, 2008.

139-10.Oida Y., Izuta H., Oyagi A., Shimazawa M., Kudo T., Imaizumi K. and Hara H.
Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil.
Brain Res. (IF: 2.623), 1208, 217-224, 2008.

140-11.Sasaoka M., Nakamura K., Shimazawa M., Ito Y., Araie M. and Hara H.
Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model.
Exp. Eye Res. (IF: 3.259), 86, 770-782, 2008.

141-12.Matsunaga N., Chikaraishi Y., Izuta H., Ogata N., Shimazawa M., Matsumura M. and Hara H.
Role of soluble vascular endothelial growth factor receptor-1 in the vitreous in proliferative diabetic retinopathy.
Ophthalmology (IF: 5.296), 115, 1916-1922, 2008.

142-13.Ito Y., Nakamura S., Tanaka H., Shimazawa M., Araie M. and Hara H.
Memantine protects against secondary neuronal degeneration in lateral geniculate nucleus and superior colliculus after retinal damage in mice.
CNS Neuroscience & Therapeutics (IF: 4.432), 14, 192-202, 2008.

143-14.Nonaka Y., Shimazawa M., Yoshimura S., Iwama T. and Hara H.
Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice.
Neurosci. Lett. (IF: 2.026), 441, 224-228, 2008.

144-15.Nakajima Y., Inokuchi Y., Nishi M., Shimazawa M., Otsubo K. and Hara H.
Coenzyme Q_¹⁰ protects retinal cells against oxidative stress in vitro and in vivo.
Brain Res. (IF: 2.623), 1226, 226-233, 2008.

145-16.Nakajima Y., Inokuchi Y., Shimazawa M., Otsubo K. Ishibashi T. and Hara H.
Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in vitro and in vivo.
J. Pharmacy & Pharmacology (IF: 1.847). 60, 1365-1374, 2008.

146-17.Shimazawa M., Inokuchi Y., Okuno T., Nakajima Y., Sakaguchi G., Kato A., Oku H., Sugiyama T., Kudo T., Ikeda T., Takeda M. and Hara H.
Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N- methyl-D-aspartate receptor signaling.
J. Neurochem. (IF: 4.500), 107, 279-290, 2008.

147-18.Izuta H., Shimazawa M., Tazawa S., Araki Y., Mishima S. and Hara H.
Protective effects of Chinese propolis and its component, chrysin against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells.
J. Agricul. Food Chem. (IF: 2.562), 56, 8944-8953, 2008.

148-19.Uchibayashi R., Yokoyama Y., Nakajima Y., Matsunaga N., Shimazawa M. and Hara H.
Antiangiogenic effects of Chinese medicines (Hachimijiogan and Kogikujiogan) on vascular endothelial growth factor-A-induced tube formation in human umbilical vein endothelial cells co-cultured with fibroblasts.
J. Complement. Integr. Med., 5, 1, 20, 2008.

149-20.Koumura A., Nonaka Y., Hyakkoku K., Oka T., Shimazawa M., Hozumi I., InuzukaT. and Hara H.
A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice.
Neuroscience (IF: 3.556), 157, 309-318, 2008.

ページ頭に戻る

2009
150-1.Inokuchi Y., Nakajima Y., Shimazawa M., Kurita T., Kubo M., Saito A., Sajiki H., Kudo T., Aihara M., Imaizumi K., Araie M. and Hara H.
Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 50, 334-344, 2009.

151-2.Izuta H., Chikaraishi Y., Shimazawa M., Mishima S. and Hara H.
10-Hydroxy-2-decenoic acid, a major fatty acid from Royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells.
eCAM (IF: 2.535), 6, 489-494, 2009.
http://ecam.oxfordjournals.org/cgi/content/abstract/6/4/489?etoc

152-3.Inokuchi Y., Shimazawa M., Nakajima Y., Komuro I., Matsuda T., Baba A., Araie M., Kita S., Iwamoto T. and Hara H.
A Na⁺/Ca²⁺ exchanger isoform, NCX1, involves in retinal cell death after N-Methyl-D-aspartate and ischemia-reperfusion.
J. Neurosci. Res. (IF: 2.974), 87, 906-917, 2009.

153-4.Imamura K., Onoe H., Shimazawa M., Nozaki S., Wada Y., Kato K., Nakajima H., Mizuma H., Onoe K., Taniguchi T., Sasaoka M., Hara H., Tanaka S., Araie M. and Watanabe Y.
Molecular imaging reveals unique degenerative changes in experimental glaucoma.
NeuroReport (IF: 1.904), 20, 139-144, 2009.

154-5.Matsunaga N., Imai S., Inokuchi Y., Shimazawa M., Yokota S., Araki Y. and Hara H.
Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo.
Molecular Nutrition and Food Research (IF: 4.713), 53, 869-877, 2009.

155-6. Shimazawa M., Nakajima Y., Mashima Y. and Hara H.
Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells
Brain Res. (IF: 2.623), 1251, 269-275, 2009.

156-7.Hyakkoku K., NakajimaY., Izuta H., Shimazawa M., Yamamoto T., Shibata N. and Hara H.
Thalidomide protects against ischemic neuronal damage induced by
focal cerebral ischemia in mice.
Neuroscience (IF: 3.556), 159, 760-769, 2009.

157-8.Nakajima Y., Shimazawa M., Otsubo K., Ishibashi T. and Hara H.
Zeaxanthin, a retinal carotenoid, protects retinal cells against oxidative stress.
Curr. Eye Res. (IF: 1.519), 34, 311-318, 2009.

158-9.Nakajima Y., Shimazawa M., Mishima S. and Hara H.
Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis.
Phytotherapy Research (IF: 2.086), 23, 1431-1438, 2009.

159-10.Nonaka Y., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H.
Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage.
Neurosci. Lett. (IF: 2.026), 452, 156-161, 2009.

160-11.Nakajima Y., Tsuruma K., Shimazawa M., Mishima S. and Hara H.
Comparison of bee products based on assays of antioxidant capacities.
BMC Complement. Altern. Med. (IF: 2.082), 9: 4, 2009.
http://www.biomedcentral.com/1472-6882/9/4

161-12.Inokuchi Y., Imai S., Nakajima Y., Shimazawa M. and Hara H.
Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo.
J. Pharmacol. Exp. Ther. (IF: 4.309), 329, 687-698, 2009.

162-13.Hironaka K., Inokuchi Y., Tozuka Y., Shimazawa M., Hara H. and Takeuchi H.
Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye.
J. Control. Release (IF: 5.69), 136, 247-253, 2009.

163-14.Yamamoto T., Shibata N., Sukeguchi D., Takashima M., Nakamura S., Toru T., Matsunaga N., Hara H., Tanaka M., Obata T. and Sasaki T.
Synthesis, configurational stability and stereochemical biological evaluations of (S)- and (R)-5-hydroxythalidomides.
Bioorg. Med. Chem. Lett. (IF: 2.531), 19, 3973-3976, 2009.

164-15.Tanaka H., Ito Y., Nakamura S., Shimazawa M. and Hara H.
Involvement of brain-derived neurotrophic factor in time-dependent neurodegeneration in the murine superior colliculus after intravitreal injection of N-methyl-D-aspartate.
Mol. Vision (IF: 2.464), 15, 662-669, 2009.

165-16.Ito Y., Shimazawa M., Chen Y. N., Tsuruma K., Yamashita T., Araie M. and Hara H.
Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys.
Exp. Eye Res. (IF: 3.259), 89, 246-255, 2009.

166-17.Nonaka Y., Koumura A., Hyakkoku K., Shimazawa M., Yoshimura S., Iwama T. and Hara H.
Combination treatment with normobaric hyperoxia and cilostazol protects mice against focal cerebral ischemia-induced neuronal damage better than each treatment alone.
J. Pharmacol. Exp. Ther. (IF: 4.309), 330, 13-22, 2009.

167-18.Chikaraishi Y., Shimazawa M., Yokota K., Yoshino K. and Hara H.
CB-12181, a new azasugar-based matrix metalloproteinase/tumor necrosis factor-α converting enzyme inhibitor, inhibits vascular endothelial growth factor-induced angiogenesis in vitro and retinal neovascularization in vivo.
Current Neurovascular Research (IF: 3.571), 6, 140-147, 2009.

168-19.Maruyama H., Sumitou Y., Sakamoto T., Araki Y. and Hara H.
Antihypertensive effects of flavonoids isolated from Brazilian green propolis in spontaneously hypertensive rats.
Biol. Pharm. Bull. (IF: 1.849), 32, 1244-1250, 2009.

169-20.Koumura A., Hamanaka J., Shimazawa M., Honda A., Tsuruma K., Uchida Y., Hozumi I., Satoh M., Inuzuka T. and Hara H.
Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia.
Brain Res. (IF: 2.623), 1292, 148-154, 2009.

170-21.Kakefuda K., Fujita Y., Oyagi A., Hyakkoku K., Kojima T., Umemura K., Tsuruma K., Shimazawa M., Ito M., Nozawa Y. and Hara H.
Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.
Biochemical and Biophysical Research Communications (IF: 2.484), 387, 784-788, 2009.

171-22.Ito Y., Yamada M., Tanaka H., Aida K., Tsuruma K., Shimazawa M., Hozumi I., Inuzuka T., Takahashi H. and Hara H.
Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice.
Neurobiology of Disease (IF: 4.852), 36, 470-476, 2009.

172-23.Izuta H., Narahara Y., Shimazawa M., Mishima S., Kondo S. and Hara H.
1,1-Diphenyl-2-Picrylhydrazyl (DPPH) Radical Scavenging Activity of Bee Products and Their Constituents Determined by ESR
Biol. Pharm. Bull. (IF: 1.849), 32, 1947-1951, 2009.

173-24.Koumura A., Kakefuda K., Honda A., Ito Y., Tsuruma K., Shimazawa M., Uchida Y., Hozumi I., Satoh M., Inuzuka T. and Hara H.
Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors.
Neurosci. Lett. (IF: 2.026), 467, 11-14, 2009.

174-25.Oyagi A., Oida Y., Kakefuda K., Shimazawa M., Shioda N., Moriguchi S., Kitaichi K., Nanba D., Yamaguchi K., Furuta Y., Fukunag K., Higashiyama S. and Hara H.
Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice.
PLoS ONE (IF: 3.730), 4(10) : e7461, 2009.

175-26.Izuta H., Chikaraishi Y., Adachi T., Shimazawa M., Sugiyama T., Ikeda T., and Hara H.
Extracellular SOD and VEGF are increased in vitreous body from proliferative diabetic retinopathy patients.
Mol. Vision (IF: 2.464), 15, 2663-2672, 2009.
http://www.molvis.org/molvis/v15/a283/

176-27.Izuta H.,Shimazawa M., Tsuruma K., Araki Y., Mishima S. and Hara H.
Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells.
BMC Complementary and Alternative Medicine (IF: 2.082), 9: 45, 2009.
http://www.biomedcentral.com/1472-6882/9/45

ページ頭に戻る

2010
177-1.Nakamura S., Chikaraishi Y., Tsuruma K., Shimazawa M. and Hara H.
Ruboxistaurin, a PKCβ inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
Exp. Eye Res. (IF: 3.259), 90, 137-145, 2010.

178-2.Matsunaga N., Chikaraishi Y., Shimazawa M., Yokota S. and Hara H.
Vaccinium myrtillus(Bilberry) extracts reduce angiogenesis in vitro and in vivo.
eCAM (IF: 2.535), 7, 47-56, 2010.
http://ecam.oxfordjournals.org/cgi/content/full/7/1/47

179-3.Shimazawa M., Suemori S., Inokuchi Y., Matsunaga N., Nakajima Y., Oka T., Yamamoto T. and Hara H.
A novel calpain inhibitor, ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945), reduces murine retinal cell death in vitro and in vivo.
J. Pharmacol. Exp. Ther. (IF: 4.309), 332, 380-387, 2010.

180-4.Ito Y., Nakamura S., Tanaka H., Tsuruma K., Shimazawa M., Araie M. and Hara H.
Lomerizine, Ca²⁺-channel blocker, protects against neuronal degeneration within the visual center of the brain after retinal damage in mice.
CNS Neuroscience and Therapeutics (IF: 4.432), 16, 103-114, 2010.

181-5.Matsunaga N., Tsuruma K., Shimazawa M., Yokota S. and Hara H.
Inhibitory actions of Bilberry anthocyanidins on angiogenesis.
Phytotherapy Research (IF: 2.086), 24, S42-S47, 2010.

182-6.Chikaraishi Y., Izuta H., Shimazawa M., Mishima S. and Hara H.
Angiostatic effects of Brazilian green propolis and its chemical constituents.
Molecular Nutrition and Food Research (IF: 4.713), 54, 566-575, 2010.

183-7.Hino S., Kondo S., Yoshinaga K., Saito A., Murakami T., Kanemoto S., Sekiya H., Chihara K., Aikawa Y., Hara H., Kudo T., Sekimoto T., Funamoto T., Chosa E. and Imaizumi K.
Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis.
J. Bone and Mineral Metabolism (IF: 2.1), 28, 131-138, 2010.

184-8.Sato T., Oku H., Tsuruma K., Katsumura K., Shimazawa M., Hara H., Sugiyama T. and Ikeda T.
Effect of Hypoxia on Susceptibility of RGC-5 Cells to Nitric Oxide.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 51, 2575-258, 2010.

185-9.Inokuchi Y.,† Hironaka K.,† Fujisawa T., Tozuka Y., Tsuruma K., Shimazawa M., Takeuchi H. and Hara H, † contributed equally
Physicochemical properties affecting retinal delivery of nanoparticulate systems via eyedrop administration.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 51,3162-3170, 2010.

186-10.Izuta H., Matsunaga N., Shimazawa M., Sugiyama T., Ikeda T. and Hara H.
Proliferative diabetic retinopathy and relations among antioxidant activity, oxidative stress, and VEGF in the vitreous body.
Mol. Vision (IF: 2.464), 16, 130-136, 2010.

187-11.Honda A., Komuro H., Hasegawa T., Seko Y., Shimada A., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y and Satoh M.
Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity.
The Journal of Toxicological Sciences, 35, 209-215, 2010.

188-12.Honda A., Komuro H., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y and Satoh M.
Microarray analysis of the liver in metallothionein-III null mice treated with cadmium.
The Journal of Toxicological Sciences, 35, 271-273, 2010.

189-13.Tsuruma K., Tanaka Y., Shimazawa M. and Hara H.
Induction of amyloid precursor protein by the neurotoxic peptide, amyloid-beta 25-35, causes retinal ganglion cell death.
Journal of Neurochemistry (IF: 4.061), 113, 1545-1554, 2010.

190-14.Imai S., Inokuchi Y., Nakamura S., Tsuruma K., Shimazawa M. and Hara H.
Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina.
Eur. J. Pharmacol. (IF: 2.737), 642, 77-85, 2010

191-15.Kakino M., Izuta H., Ito T., Tsuruma K., Araki Y., Shimazawa M., Oyama M., Iinuma M. and Hara H.
Agarwood induces laxative effects via acetylcholine receptors on loperamide-induced constipation in mice.
Biosci. Biotech. Biochem. (IF: 1.39), 74, 1550-1555, 2010

192-16.Maruyama H., Sakamoto T., Araki Y. and Hara H.
Anti-inflammatory effect of bee pollen ethanol extract from Cistus sp. of Spanish on carrageenan-induced rat hind paw edema.
BMC Complementary and Alternative Medicine (IF: 2.082), 10:30, 2010.

193-17.Shirai Y., Kozuki T., Kakefuda K., Moriguchi S., Oyagi A., Horie K., Shimazawa M., Fukunaga K., Takeda J., Saito N. and Hara H.
Essential role of diacylglycerol kinase beta (DGKβ) in neurite spine formation, cognitive function, and memory.
PLoS ONE (IF: 3.730), 5(7) : e11602, 2010

194-18.Oyagi A., Ogawa K., Kakino M. and Hara H.
Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice.
BMC Complementary and Alternative Medicine (IF: 2.082), 10:45, 2010.

195-19.Kawase K., Lin W., Aoyama Y., Yamamoto T., Shimazawa M. and Hara H.
Effects of timolol-related ophthalmic solutions on cultured human conjunctival cells.
Jpn. J. Ophthalmol., 54, 615-621, 2010.

196-20.Oida Y., Hamanaka J., Hyakkoku K., Shimazawa M., Kudo T., Imaizumi K., Yasuda T. and Hara H.
Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice.
Neurosci. Lett. (IF: 2.026), 484, 43-46, 2010.

197-21.Hyakkoku K., Hamanaka J.,Tsuruma K., Shimazawa M., Tanaka H., Uematsu S., Akira S., Inagaki N., Nagai H. and Hara H.
Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia.
Neuroscience (IF: 3.556), 171, 258-267, 2010.

198-22.Imai S., Shimazawa M., Nakanishi T., Tsuruma K. and Hara H.
Calpain inhibitor protects cells against light-induced retinal degeneration.
J. Pharmacol. Exp. Ther. (IF: 4.309), 335, 645-652, 2010.

199-23.Honda A., Komuro H., Shimada A., Hasegawa T., Seko Y., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y. and Satoh M.
Attenuation of cadmium-induced testicular injury in metallothionein-III null mice.
Life Sciences (IF: 2.527), 87, 545-550, 2010.

200-24.Kakefuda K,, Oyagi A., Ishisaka M., Tsuruma K., Shimazawa M., Yokota K., Shirai Y., Horie K., Saito N., Takeda J. and Hara H.
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.
PLoS ONE (IF: 3.730), 5(10) : e13447, 2010.

201-25.Ishiguro M., Mishiro K., Fujiwara Y., Chen H., Izuta H., Tsuruma K., Shimazawa M., Yoshimura S., Satoh M., Iwama T.and Hara H.
Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tissue plasminogen activator.
PLoS ONE (IF:3.730), 5(12) : e15178, 2010.

202-26.Shimazawa M., Tanaka H., Ito Y., Morimoto N., Tsuruma K., Kadokura M., Tamura S., Inoue Y., Yamada M., Takahashi H., Warita H., Aoki M. and Hara H.
An inducer of VGF protects cells from ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS.
PLoS ONE (IF: 3.730), 5(12) : e15307, 2010.

203-27.Kakino M., Tazawa S., Maruyama H., Tsuruma K., Araki Y., Shimazawa M. and Hara H.
Laxative effects of agarwood on low-fiber diet-induced constipation in rats.
BMC Complementary and Alternative Medicine (IF: 2.082), 10: 68, 2010.

204-28.Hyakkoku K., Hamanaka J., Tsuruma K., Shimazawa M. and Hara H.
Proteomic approach with LCMS-IT-TOF identified an increase of Rab33B after transient focal cerebral ischemia in mice.
Experimental & Translational Stroke Medicine, 2:20, 2010.

205-29.Hayashi E., Kuratani K., Kinoshita M. and Hara H.
Pharmacologically distinctive behaviors other than burying marbles during the marble burying test in mice.
Pharmacology (IF: 1.833), 86, 293-296, 2010.

ページ頭に戻る

2011
206-1.Yamauchi M., Tsuruma K., Imai S., Nakanishi T., Umigai N., Shimazawa M. and Hara H.
Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity.
Eur. J. Pharmacol. (IF: 2.737), 650, 110-119, 2011.

207-2.Akane M., Shimazawa M., Inokuchi Y., Tsuruma K.and Hara H.
SUN N8075, a novel radical scavenger, protects against retinal cell death in mice.
Neurosci. Lett. (IF: 2.026), 488, 87-91, 2011.

208-3.Tanaka H., Shimazaki H., Kimura M., Izuta H., Tsuruma K., Shimazawa M. and Hara H.
Apoptosis-inducing factor and cyclophilin a cotranslocate to the motor neuronal nuclei in amyotrophic lateral sclerosis model mice.
CNS Neuroscience and Therapeutics (IF: 4.432), 17, 294-304, 2011.

209-4.Nishioka Y., Oyagi A., Tsuruma K., Shimazawa M., Ishibashi T. and Hara H.
The antianxiety-like effect of astaxanthin extracted from Paracoccus carotinifaciens.
BioFactors (IF: 1.23), 37, 25-30, 2011.

210-5.Ishisaka M., Kudo T., Shimazawa M., Kakefuda K., Oyagi A., Hyakkoku K., Tsuruma K. and Hara H.
Restraint-induced expression of endoplasmic reticulum stress-related genes in the mouse brain.
Pharmacology & Pharmacy, 2, 10-16, 2011.

211-6.Tanaka J., Nakanishi T., Ogawa K., Tsuruma K., Shimazawa M., Shimoda H. and Hara H.
Purple rice extract and anthocyanidins of the constituents protect light-induced retinal damage in vitro and in vivo.
Journal of Agricultural and Food Chemistry (IF: 2.906), 59, 528-536, 2011.

212-7.Ito Y., Shimazawa M., Inokuchi Y., Yamanaka H., Tsuruma K., Imamura K., Onoe H., Watanabe Y., Aihara M., Araie M. and Hara H.
Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model.
European Journal of Neuroscience (IF: 3.418), 33, 843-855, 2011.

213-8.Nakamura S., Hayashi K., Takizawa H., Murase T., Tsuruma K., Shimazawa M., Kakuta H., Nagasawa H. and Hara H.
An Arylidene-Thiazolidinedione Derivative, GPU-4, without PPARγ Activation, Reduces Retinal Neovascularization.
Current Neurovascular Research (IF: 3.571), 8, 25-34, 2011.

214-9.Ogawa K., Oyagi A., Tanaka J., Kobayashi S. and Hara H.
The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice.
Phytotherapy Research (IF: 2.086), 25, 1160-1165, 2011.

215-10.Hayashi E., Shimamura M., Kuratani K., Kinoshita M. and Hara H.
Automated experimental system capturing three behavioral components during murine forced swim test.
Life Sciences (IF: 2.527), 88, 411-417, 2011.

216-11.Nakamura S., Morimoto N., Tsuruma K., Izuta H., Yasuda Y., Kato N., Ikeda T., Shimazawa M. and Hara H.
Tissue kallikrein inhibits retinal neovascularization via the cleavage of vascular endothelial growth factor-165.
Arteriosclerosis, Thrombosis, and Vascular Biology (IF: 7.235), 31, 1041-1048, 2011.

217-12.Hironaka K., Inokuchi Y., Fujisawa T., Shimazaki H., Akane M., Tozuka Y., Tsuruma K., Shimazawa M., Hara H. and Takeuchi H.
Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage.
European Journal of Pharmaceutics and Biopharmaceutics (IF: 3.151), 79, 119-125, 2011.

218-13.Hironaka K., Fujisawa T., Sasaki H., Tozuka Y., Tsuruma K., Shimazawa M., Hara H. and Takeuchi H.
Fluorescence investigation of the retinal delivery of hydrophilic compounds via liposomal eyedrops.
Biological and Pharmaceutical Bulletin (IF: 1.849), 34, 894-897, 2011.

219-14.Ishiguro M., Suzuki Y., Mishiro K., Kakino M., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H.
Blockade of phosphodiesterase-III protects against oxygen-glucose deprivation in endothelial cells by upregulation of VE-cadherin.
Current Neurovascular Research (IF: 3.571), 8, 86-94, 2011.

220-15.Oyagi A., Morimoto N., Hamanaka J., Ishiguro M., Tsuruma K., Shimazawa M. and Hara H.
Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury.
Neuroscience (IF: 3.556), 185, 116-124, 2011.

221-16.Uchibayashi R., Tsuruma K., Inokuchi Y., Shimazawa M. and Hara H.
Involvement of Bid and caspase-2 in endoplasmic reticulum stress- and oxidative stress-induced retinal ganglion cell death.
J. Neurosci. Res. (IF: 2.974), 89, 1783-1794, 2011.

222-17.Adachi T., Yasuda H., Nakamura S., Kamiya T., Hara H., Hara H. and Ikeda T.
Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase.
Free Radical Research (IF: 2.215), 45, 1083-1092, 2011.

223-18.Numajiri N., Takasawa K., Nishiya T., Tanaka H., Ohno K., Hayakawa W., Asada M., Matsuda H., Azumi K., Kamata H., Nakamura T., Hara H., Minami M., Lipton S. A. and Uehara T.
On−off system for PI3-kinase−Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN).
Proceedings of the National Academy of Sciences USA (IF: 9.432), 108, 10349-10354, 2011.

224-19.Ishisaka M., Kakefuda K., Yamauchi M., Tsuruma K., Shimazawa M., Tsuruta A. and Hara H.
Luteolin shows an antidepressant-like effect via supressing endoplasmic reticulum stress.
Biol. Pharm. Bull. (IF: 1.849), 34, 1481-1486, 2011.

225-20.Yoshikawa T., Ogata N., Izuta H., Shimazawa M., Hara H. and Takahashi K.
Increased expression of tight junctions in APRE19 cells under endoplasmic reticulum stress.
Current Eye Research (IF: 1.519), 36, 1153-1163, 2011.

226-21.Shimazaki H., Hironaka K., Fujisawa T., Tsuruma K., Tozuka Y., Shimazawa M., Takeuchi H. and Hara H.
Edaravone-loaded liposome eye drops protect against light-induced retinal damage in mice.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 52, 7289-7297, 2011.

227-22.Oyagi A., Moriguchi S., Nitta A., Murata K., Oida Y., Tsuruma K., Shimazawa M., Fukunaga K. and Hara H.
Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation.
Brain Res. (IF: 2.623), 1419, 97-104, 2011.

228-23.Hayashi E., Kobayashi T., Shiroshita Y., Kuratani K., Kinoshita M. and Hara H.
An automated evaluation system for analyzing antinociceptive effects on intracolonic capsaicin-induced visceral pain-related licking behavior in mice.
J. Pharmacol. Toxicol. Methods., 64, 119-123, 2011.

229-24.Tsuruma K., Tanaka Y., Shimazawa M., Mashima Y. and Hara H.
Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels.
Molecular Vision (IF: 2.511), 17, 3556-3565, 2011.

230-25.Ogishima H., Nakamura S., Nakanishi T., Imai S., Kakino M., Ishizuka F., Tsuruma K., Shimazawa M. and Hara H.
Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 52, 9710-9720, 2011.

231-26.Koumura A., Hamanaka J., Kawasaki K., Tsuruma K., Shimazawa M., Hozumi I., Inuzuka T. and Hara H.
Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.
J. Pharmacol. Exp. Ther. (IF: 4.309), 338, 337-344, 2011.


ページ頭に戻る

2012
232-1.Tanaka J., Nakamura S., Tsuruma K., Shimazawa M., Shimoda H. and Hara H.
Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis.
Phytotherapy Research (IF: 2.086), 26, 214-222, 2012.

233-2.Ito Y., Shimazawa M., Tsuruma K., Mayama C., Ishii K., Onoe H., Aihara M., Araie M. and Hara H.
Induction of amyloid-β_1-42 in the retina and optic nerve head of chronic ocular hypertensive monkeys.
Molecular Vision (IF: 2.511), 18, 2647-2657, 2012.

234-3.Murata K., Oyagi A., Takahira D., Tsuruma K., Shimazawa M., Ishibashi T., Hara H.
Protective effects of astaxanthin from Paracoccus carotinifaciens on murine gastric ulcer models.
Phytotherapy Research (IF: 2.086), 26, 1126-1132, 2012.

235-4.Ito T., Kakino M., Tazawa S., Watarai T., Oyama M., Maruyama H., Araki Y., Hara H. and Iinuma M.
Quantification of polyphenols and pharmacological analysis of water and ethanol-based extracts of cultivated agarwood leaves.
Journal of Nutritional Science and Vitaminology (IF: 1.228), 58, 136-142, 2012.

236-5.Shimazawa M., Ito Y., Inokuchi Y., Yamanaka H., Nakanishi T., Hayashi T., Ji B., Higuchi M., Suhara T., Imamura K., Araie M., Watanabe Y., Onoe H. and Hara H.
An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: In vivo positron emission tomography imaging of glial activation.
PLoS ONE (IF: 3.730), 7(1), e30526, 2012.

237-6.Mishiro K., Ishiguro M., Suzuki Y., Tsuruma K., Shimazawa M. and Hara H.
A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice.
Neuroscience (IF: 3.556), 205, 39-48, 2012.

238-7.Tsuruma K., Yamauchi M., Inokuchi Y., Sugitani S., Shimazawa M. and Hara H.
Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice.
Journal of Pharmacological Sciences (IF: 2.260), 118, 351-362, 2011.

239-8.Tsuruma K., Shimazaki H., Nakashima K., Yamauchi M., Sugitani S., Shimazawa M., Iinuma M. and Hara H.
Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo.
Molecular Nutrition & Food Research (IF: 4.713), 56, 713-724, 2012.

240-9.Nakamura S., Imai S., Ogishima H., Tsuruma K., Shimazawa M. and Hara H.
Morphological and functional changes in the retina after chronic oxygen-induced retinopathy.
PLoS ONE (IF: 3.730), 7(2), e32167, 2012.

241-10.Hong S., Hara H., Shimazawa M., Hyakkoku K., Kim C. Y., and Seong G. J.
Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic artery.
Brazilian Journal of Medical and Biological Research (IF: 1.150), 45, 212-215, 2012.

242-11.Umigai N., Tanaka J., Tsuruma K., Shimazawa M. and Hara H.
Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation.
Current Neurovascular Research (IF: 3.571), 9, 102-109, 2012.

243-12.Shimazawa M., Miwa A., Ito Y., Tsuruma K., Aihara M. and Hara H.
Involvement of endoplasmic reticulum stress in optic nerve degeneration following N-methyl-D-aspartate-induced retinal damage in mice.
Journal of Neuroscience Research (IF: 2.974), 90, 1960-1969, 2012.

244-13.Kakino M., Sugiyama T., Kunieda H., Tazawa S., Maruyama H., Tsuruma K., Araki Y., Shimazawa M., Ichihara K., Mori H. and Hara H.
Agarwood (Aquilaria crassna) extracts decrease high-protein high-fat diet-induced intestinal putrefaction toxins in mice.
Pharmaceutica Analytica Acta (IF: 1.4), 3:152, 2012.

245-14. Nakamura S., Tsuruma K., Shimazawa M. and Hara H.
Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression.
European Journal of Pharmacology (IF:2.737), 685, 8-14, 2012.

246-15.Ishisaka M., Kakefuda K., Oyagi A., Ono Y., Tsuruma K., Shimazawa M., Kitaichi K. and Hara H.
Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivity.
PLoS ONE (IF: 3.730), 7(5), e37058, 2012.

247-16.Egashira Y., Sugitani S., Suzuki Y., Mishiro K., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H.
The conditioned medium of murine and human adipose-derived stem cells exerts neuroprotective effects against experimental stroke model.
Brain Research (IF: 2.623), 1461, 87-95, 2012.

248-17.Kasai H., Ishisaka M., Shirasawa E. and Hara H.
A three-dimensional collagen gel contraction monitoring system that uses a porcine trabecular meshwork for screening of anti-intraocular pressure agents.
Pharmaceutica Analytica Acta (IF: 1.4), 3:154, 2012.

249-18.Ishiguro M., Kawasaki K., Suzuki Y., Ishizuka F., Mishiro K., Egashira Y., Ikegaki I., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H.
A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue prasminogen activator.
Neuroscience (IF: 3.556), 220, 302-312, 2012.

250-19.Ito T., Kakino M., Tazawa S., Oyama M., Maruyama H., Araki Y., Hara H. and Iinuma M.
Identification of phenolic compounds in Aquilaria crassna leaves via liquid chromatography-electrospray ionization mass spectroscopy.
Food Science and Technology Research (IF: 0.439), 18, 259-262, 2012.

251-20.Ohno Y., Nakanishi T., Umigai N., Tsuruma K., Shimazawa M. and Hara H.
Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice.
European Journal of Pharmacology (IF: 2.737), 690, 84-89, 2012.

252-21.Tanaka H., Shimazawa M., Kimura M., Takata M., Tsuruma K., Yamada M., Takahashi H., Hozumi I., Niwa J., Iguchi Y., Nikawa T., Sobue G., Inuzuka T. and Hara H.
The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis.
Scientific Reports (IF: 2.972), 2: 573, 2012.

253-22.Tsuruma K., Nishimura Y., Kishi S., Shimazawa M., Tanaka T. and Hara H.
SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 53, 6729-6737, 2012.

254-23.Ono Y., Shimazawa M., Ishisaka M., Oyagi A., Tsuruma K. and Hara H.
Imipramine protects mouse hippocampus against tunicamycin-induced cell death.
European Journal of Pharmacology (IF: 2.737), 696, 83-88, 2012.

255-24.Kakino M., Izuta H., Tsuruma K., Araki Y., Shimazawa M., Ichihara K. and Hara H.
Laxative effects and mechanism of action of Brazilian green propolis.
BMC Complementary and Alternative Medicine (IF: 2.082), 12:192, 2012.

256-25.Suzuki Y., Hattori K., Hamanaka J., Murase T., Egashira Y., Mishiro K., Ishiguro M., Tsuruma K., Hirose Y., Tanaka H., Yoshimura S., Shimazawa M., Inagaki N., Nagasawa H., Iwama T. and Hara H.
Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia.
Scientific Reports (IF: 2.972), 2: 896, 2012.

257-26.Morimoto N., Kita S., Shimazawa M., Namimatsu H., Tsuruma K., Hayakawa K., Mishima K., Egashira N., Iyoda T., Horie I., Gotoh Y., Iwasaki K., Fujiwara M., Matsuda T., Baba A., Komuro I., Horie K., Takeda J., Iwamoto T. and Hara H.
Preferential involvement of Na⁺/Ca²⁺ exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice.
Biochemical and Biophysical Research Communications (IF: 2.484), 429, 186-190, 2012.

258-27.Tsuruma K., Shimazaki H., Ohno Y., Inoue Y., Honda A., Imai S., Lee J., Shimazawa M., Satoh M. and Hara H.
Metallothionein-III deficiency exacerbates light-induced retinal degeneration.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 53, 7896-7903, 2012.

ページ頭に戻る

2013
259-1.Mishiro K., Ishiguro M., Suzuki Y., Tsuruma K., Shimazawa M. and Hara H.
Tissue plasminogen activator prevents restoration of tight junction proteins through upregulation of angiopoietin-2.
Current Neurovascular Research (IF: 3.571), 10, 39-48, 2013.

260-2.Tanaka J., Nakanishi T., Shimoda H., Nakamura S., Tsuruma K., Shimazawa M., Matsuda H., Yoshikawa M. and Hara H.
Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo.
Life Sciences (IF: 2.527), 92, 17-25, 2013.

261-3.Nakanishi T., Shimazawa M., Sugitani S., Kudo T., Imai S., Inokuchi Y., Tsuruma K. and Hara H.
Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice.
Journal of Neurochemistry (IF: 4.061), 125, 111-124, 2013.

262-4.Kasai, H., Imamura T., Tsuruma K., Takahashi Y., Kurasawa T., Hirata H., Shimazawa M. and Hara H.
Effects of roscovitine, a cell cycling-dependent kinase inhibitor, on intraocular pressure of rabbit and retinal ganglion cell damage.
Neuroscience Letters (IF: 2.026), 535, 95-99, 2013.

263-5.Hayashi T., Shimazawa M., Watabe H., Ose T., Inokuchi Y., Ito Y., Yamanaka H., Urayama S., Watanabe Y., Hara H. and Onoe H.
Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma.
Molecular Neurodegeneration (IF: 4.28), 8:4, 2013.

264-6.Tanaka J., Kadekaru T., Ogawa K., Hitoe S., Shimoda H. and Hara H.
Maqui berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light.
Food Chemistry (IF: 3.655), 139, 129-137, 2013.

265-7.Takano N., Tsuruma K., Ohno Y., Shimazawa M. and Hara H.
Bimatoprost protects retinal neuronal damage via Akt pathway.
European Journal of Pharmacology (IF: 2.737), 702, 56-61, 2013.

266-8.Ishizuka F., Shimazawa M., Umigai N., Ogishima H., Nakamura S., Tsuruma K. and Hara H.
Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice.
European Journal of Pharmacology (IF: 2.737), 703, 1-10, 2012.

267-9.Tanaka H., Shimazawa M., Takata M., Kaneko H., Tsuruma K., Ikeda T., Warita H., Aoki M., Yamada M., Takahashi H., Hozumi I., Minatsu H., Inuzuka T. and Hara H.
ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis.
Journal of Neurology (IF:3.473), 260, 1782-1797, 2013.

268-10.Nakamura S.^#, Takizawa H.^#, Shimazawa M.^#, Hashimoto Y., Sugitani S., Tsuruma K. and Hara H. ^#: Contributed equally
Mild endoplasmic reticulum stress promotes retinal neovascularization via induction of BiP/GRP78.
PloS ONE (IF: 3.730), 8(3), e60517, 2013.

269-11.Ishisaka M., Tsuruma K., Shimazawa M., Shirai Y., Saito N. and Hara H.
Increased seizure susceptibility in a mouse with diacylglycerol kinase β deficiency.
Neuroscience & Medicine, 4, 117-122, 2013.

270-12.Shimazawa M., Nakamura S., Miwa M., Tsuruma K., Aihara M., Nakamura K. and Hara H.
Establishment of the ocular hypertension model using the common marmoset.
Experimental Eye Research (IF: 3.259), 111, 1-8, 2013.

271-13.Ono Y., Tanaka H., Tsuruma K., Shimazawa M. and Hara H.
A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells.
Biochemical and Biophysical Research Communications (IF: 2.484), 434, 904-909, 2013.

272-14.Inoue Y., Tsuruma K., Nakanishi T., Oyagi A., Ohno Y., Otsuka T., Shimazawa M. and Hara H.
Role of heparin-binding epidermal growth factor-like growth factor in light-induced photoreceptor degeneration in mouse retina.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 54, 3815-3829, 2013.

273-15.Ohno Y., Makita S., Shimazawa M., Tsuruma K., Yasuno Y. and Hara H.
Thickness mapping of the inner retina by spectral-domain optical coherence tomography in an N-methyl-D-aspartate-induced retinal damage model.
Experimental Eye Research (IF: 3.259), 113, 19-25, 2013.

274-16.Kitashoji A., Egashira Y., Mishiro K., Suzuki Y., Ito H., Tsuruma K., Shimazawa M. and Hara H.
Cilostazol ameliorates warfarin-induced hemorrhagic transformation after cerebral ischemia in mice.
Stroke (IF: 7.041), 44, 2862-2868, 2013.

275-17.Kasai H., Aoyama Y., Kurasawa T., Imamura T., Tsuruma K., Hara H., Hirata H. and Yamamoto T.
Comparison of efficacy and safety evaluation of latanoprost formulations with and without benzalkonium chloride.
Pharmacology & Pharmacy, 4, 377-384, 2013.

276-18.Takata M., Tanaka H., Kimura M., Nagahara Y., Tanaka K., Kawasaki K., Seto M., Tsuruma K., Shimazawa M. and Hara H.
Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis.
British Journal of Pharmacology (IF: 4.409), 170, 341-351, 2013.

277-19.Ishizuka F.^#, Shimazawa M.^#, Inoue Y., Nakano Y., Ogishima H., Nakamura S., Tsuruma K., Tanaka H., Inagaki N. and Hara H. ^#: Contributed equally
Toll-like receptor 4 mediates retinal ischemia/reperfusion injury through nuclear factor-κB and spleen tyrosine kinase activation.
Invest. Ophthalmol. Vis. Sci. (IF: 3.466), 54, 5807-5816, 2013.

278-20.Ishizuka F.^#, Shimazawa M.^#, Egashira Y., Ogishima H., Nakamura S., Tsuruma K. and Hara H. ^#: Contributed equally
Cilostazol prevents retinal ischemic damage partly via inhibition of tumor necrosis factor-α-induced nuclear factor-kappa B/activator protein-1 signaling pathway.
Pharmacology Research & Perspectives, 1, e00006, 2013.

279-21.Egashira Y., Suzuki Y., Azuma Y., Takagi T., Mishiro K., Sugitani S., Tsuruma K., Shimazawa M., Yoshimura S., Kashimata M., Iwama T. and Hara H.
The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment.
Journal of Neuroinflammation (IF: 4.351), 10: 105, 2013.

280-22.Sugitani S., Tsuruma K., Ohno Y., Kuse Y., Yamauchi M., Egashira Y., Yoshimura S., Shimazawa M., Iwama T. and Hara H.
The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage.
Experimental Eye Research (IF: 3.259), 116, 254-264, 2013.

281-23.Ogawa K., Tsuruma K., Tanaka J., Kakino M., Kobayashi S., Shimazawa M. and Hara H.
The protective effects of bilberry and lingonberry extracts against UV light-induced retinal photoreceptor cell damage in vitro.
Journal of Agricultural and Food Chemistry (IF: 2.906), 61, 10345-10353, 2013.

282-24.Suzuki Y., Nakano Y., Mishiro K., Takagi T., Tsuruma K., Nakamura M., Yoshimura S., Shimazawa M. and Hara H.
Involvements of Mincle and Syk on the changes to innate immune after ischemic stroke.
Scientific Reports (IF: 2.972), 3: 3177, 2013.


ページ頭に戻る

2014
283-1.Morishita S., Oku H., Horie T., Tonari M., Kida T., Sugiyama T., Takai S., Hara H. and Ikeda T.
Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of glial NF-κB activation.
PLoS ONE (IF: 3.730), 9(1), e84387, 2014.

284-2.Ono Y., Tanaka H., Takata M., Nagahara Y., Noda Y., Tsuruma K., Shimazawa M., Hozumi I., Hara H.
SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models.
Neuroscience Letters (IF: 2.026), 559, 174-178, 2014.

285-3.Tsuruma K., Yamauchi M., Sugitani S., Otsuka T., Ohno Y., Nagahara Y., Ikegame Y., Shimazawa M., Yoshimura S., Iwama T. and Hara H.
Progranulin, a major secretedprotein of mouse adipose-derived stem cells, inhibits light-induced retinal degeneration.
STEM CELLS Translational Medicine, 3, 42-53, 2014.

286-4.Otsuka T., Shimazawa M., Nakanishi T., Ohno Y., Inoue Y., Tsuruma K., Ishibashi T. and Hara H.
The protective effects of a dietary carotenoid, astaxanthin, on light-induced retinal damage.
Journal of Pharmacological Sciences (IF: 2.150), 123, 209-218, 2014.

287-5.Inoue Y., Shimazawa M., Nakamura S., Imamura T., Sugitani S., Tsuruma K. and Hara H.
Protective effects of placental growth factor on retinal neuronal cell damage.
Journal of Neuroscience Research (IF: 2.974), 92, 329-337, 2014.

288-6.Yoshino Y., Ishisaka M., Umigai N., Shimazawa M., Tsuruma K. and Hara H.
Crocetin prevents amyloid β_1-42-induced cell death in murine hippocampal cells.
Phramacology & Pharamacy, 5, 37-42, 2014.

289-7.Murase H., Shimazawa M., Kakino M., Ichihara K., Tsuruma K. and Hara H.
The effects of Brazilian green propolis against excessive light-induced cell damage in retina and fibroblast cells.
Evidence-Based Complementary and Alternative Medicine (IF: 1.722), online publication.

290-8.Ojino K., Shimazawa M., Ohno Y., Otsuka T., Tsuruma K. and Hara H.
Protective effect of SUN N8075, a free radical scavenger, against excessive light-induced retinal damage in mice.
Biological and Pharmaceutical Bulletin(IF: 1.849), 37, 424-430, 2014.

291-9.Masuda T., Miyakubo H., Iinuma M. and Hara H.
The antimicrobial effect of the extract of Canavalia gladiata on periodontal pathogen.
Food Function, in press.

292-10.Umetsu R., Nishibata Y., Abe J., Suzuki Y., Hara H., Nagasawa H., Kinosada Y. and Nakamura M.
Evaluation of the association between the use of oral anti-hyperglycemic agents and hypoglycemia in Japan by data mining of the Japanese adverse drug event report (JADER) database.
Yakugaku Zasshi (IF: 0.46), 134, 299-304, 2014.

293-11.Ogawa K., Kuse Y., Tsuruma K., Kobayashi S., Shimazawa M. and Hara H.
Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro.
BMC Complementary and Alternative Medicine (IF: 2.082), 14:120, 2014.

294-12.Takagi T., Kitashoji A., Iwawaki T., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H.
Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury.
Free Radical Biology & Medicine (IF:5.271), in press.


ページ頭に戻る