原著論文

2023年

Sakai Y, Egawa D, Hattori J, Morikawa Y, Suenami K, Takayama T, Nagai A, Michiue T, Ikari A, Matsunaga T.
α-Pyrrolidinononanophenone derivatives induce differentiated SH-SY5Y neuroblastoma cells apoptosis via reduction of antioxidant capacity: Involvement of NO depletion and inactivation of Nrf2/HO1 signaling pathway.
Neurotoxicology (in press)

Nagaoka Y, Oshiro K, Yoshino Y, Matsunaga T, Endo S, Ikari A.
Activation of the TGF-β1/EMT signaling pathway by claudin-1 overexpression reduces doxorubicin sensitivity in small cell lung cancer SBC-3 cells.
Arch. Biochem. Biophys. 751: 109824.

Okamoto E, Matsuda S, Yoshino Y, Morikawa Y, Suenami K, Tabuchi Y, Matsunaga T, Hayashi H, Ikari A.
Increase in paracellular leakage of amino acids mediated by aging-induced reduction of claudin-4 expression.
Nutr. 3166(23): 72621-72627.

Endo S, Morikawa Y, Matsunaga T, Hara A, Takasu M.
Characterization of a novel porcine carbonyl reductase activated by glutathione: Relationship to carbonyl reductase 1, 3α/β-hydroxysteroid dehydrogenase and prostaglandin 9-ketoreductase.
Chem. Biol. Interact. 381: 110572.

Okamoto E, Matsuda S, Yoshino Y, Morikawa Y, Suenami K, Tabuchi Y, Matsunaga T, Ikari A.
Regulation of paracellular fluxes of amino acids by claudin-8 in normal mouse intestinal MCE301 cells.
Nutrients 15(6): 1346.

Ota Atsumi,, Kawai Mina, Kudo Yudai, Segawa Jin, Hoshi Manami, Kawano Shinya, Yoshino Yuta, Ichihara Kenji, Shiota Masaki, Fujimoto Naohiro, Matsunaga Toshiyuki, Endo Satoshi, Ikari Akira.
Artepillin C overcomes apalutamide resistance through blocking androgen signaling in prostate cancer cells.
Arch. Biochem. and Biophy. 735: 109519

Matsunaga T, Horinouchi M, Saito H, Hisamatsu A, Iguchi K, Yoshino Y, Endo S, Ikari A.
Availability of aldo-keto reductase 1C3 and ATP-binding cassette B1 as therapeutic targets for alleviating paclitaxel resistance in breast cancer MCF7 cells.
J. Biochem. 173(3):167-175

2022年

Iguchi Kazuhiro, Ueyama Midori, Nishio Hiroto, Tamaki Hirofumi, Osanai Arihiro, Ino Yoko, Nonomura Kazuya, Horibe Megumi, Matsunaga Toshiyuki, Nakamura Mitsuhiro.
Impact of the increase in the number of community pharmacists on their geographical distribution in Japan: a retrospective survey.
J. Pharm. Pol. and Prac. 15(1):96

Eguchi H, Kimura R, Onuma S, Ito A, Yu Y, Yoshino Y, Matsunaga T, Endo S, Ikari A.
Elevation of anticancer drug toxicity by caffeine in spheroid model of human lung adenocarcinoma A549 cells mediated by reduction in claudin-2 and Nrf2 expression.
Int. J. Mol. Sci. 23(24): 15447.

Eguchi H, Kimura R, Matsunaga H, Matsunaga T, Yoshino Y, Endo S, Ikari A.
Increase in anticancer drug-induced toxicity by fisetin in lung adenocarcinoma A549 spheroid cells mediated by the reduction of claudin-2 expression.
Int. J. Mol. Sci. 23(14):7536.

Sakai Y, Taguchi M, Morikawa Y, Suenami K, Yanase E, Takayama T, Ikari A, Matsunaga T.
Lowering of brain endothelial cell barrier function by exposure to 4'-iodo-α-pyrrolidinononanophenone.
Chem. Biol. Interact. 364:110052.

Sakai Y, Morikawa Y, Nagao Y, Hattori J, Suenami K, Yanase E, Takayama T, Ikari A, Matsunaga T.
4'-Iodo-α-pyrrolidinononanophenone provokes differentiated SH-SY5Y cell apoptosis through downregulating nitric oxide production and bcl-2 expression.
Neurotox. Res. 40(5):1322-1336.

Endo S, Morikawa Y, Matsunaga T, Hara A, Nishinaka T.
Porcine aldo-keto reductase 1C subfamily members AKR1C1 and AKR1C4: Substrate specificity, inhibitor sensitivity and activators.
J. Steroid Biochem. Mol. Biol. 221:106113.

Kudo Y, Endo S, Fujita M, Ota A, Kamatari YO, Tanaka Y, Ishikawa T, Ikeda H, Okada T, Toyooka N, Fujimoto N, Matsunaga T, Ikari A.
Discovery and structure-based optimization of novel Atg4B inhibitors for the treatment of castration-resistant prostate cancer.
J. Med. Chem. 65(6):4878-4892.

Sakai Y, Taguchi M, Morikawa Y, Miyazono H, Suenami K, Ochiai Y, Yanase E, Takayama T, Ikari A, Matsunaga T.
Apoptotic mechanism in human brain microvascular endothelial cells triggered by 4'-iodo-α-pyrrolidinononanophenone: contribution of decrease in antioxidant properties.
Toxicol. Lett. 355:127-140.

Kobayashi M, Yonezawa A, Takasawa H, Nagao Y, Iguchi K, Endo S, Ikari A, Matsunaga T.
Development of cisplatin resistance in breast cancer MCF7 cells by up-regulating aldo-keto reductase 1C3 expression, glutathione synthesis, and proteasomal proteolysis.
J. Biochem. 171(1):97-108.

Nishikawa M, Ohara N, Naito Y, Amma C, Saito Y, Tatematsu K, Baoyindugurong J, Miyazawa D, Hashimoto Y, Okuyama H.
Dietary rapeseed (canola) oil suppresses testosterone production and increases plasma aldosterone level in stroke-prone spontaneously hypertensive rats (SHRSP).
Fund. Toxicol. Sci. 9(1):7-16

Nishikawa M, Ohara N, Naito Y, Saito Y, Amma C, Tatematsu K, Baoyindugurong J, Miyazawa D, Hashimoto Y, Okuyama H.
Rapeseed (canola) oil aggravates metabolic syndrome-like conditions in male but not in female stroke-prone spontaneously hypertensive rats (SHRSP).
Toxicol Rep.;9:256-268.

2021年

Yoshino Y, Marunaka K, Kobayashi M, Matsunaga H, Shu S, Matsunaga T, Ikari A.
Protective effects of ethanol extract of brazilian green propolis and apigenin against weak ultraviolet ray-B-induced barrier dysfunction via suppressing nitric oxide production and mislocalization of claudin-1 in HaCaT cells.
Int. J. Mol. Sci. 22(19):10326.

Endo S, Nishiyama T, Matuoka T, Miura T, Nishinaka T, Matsunaga T, Ikari A.
Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells.
Chem. Biol. Interact. 348:109634.

Hirota C, Takashina Y, Yoshino Y, Hasegawa H, Okamoto E, Matsunaga T, Ikari A.
Reactive oxygen species downregulate transient receptor potential melastatin 6 expression mediated by the elevation of miR-24-3p in renal tubular epithelial cells.
Cells. 10(8):1893.

Kamase K, Taguchi M, Ikari A, Endo S, Matsunaga T.
9,10-Phenanthrenequinone provokes dysfunction of brain endothelial barrier through down-regulating expression of claudin-5.
Toxicology. 461:152896.

Ito A, Nasako H, Akizuki R, Takashina Y, Eguchi H, Matsunaga T, Yoshino Y, Endo S, Ikari A.
Elevation of chemosensitivity of lung adenocarcinoma A549 spheroid cells by claudin-2 knockdown through activation of glucose transport and inhibition of Nrf2 signal.
Int. J. Mol. Sci. 22(12):6582.

Onuma S, Manabe A, Yoshino Y, Matsunaga T, Asai T, Ikari A.
Upregulation of chemoresistance by Mg2+ deficiency through elevation of ATP binding cassette subfamily B member 1 expression in human lung adenocarcinoma A549 cells.
Cells. 10(5):1179.

Morikawa Y, Miyazono H, Kamase K, Suenami K, Sasajima Y, Sato K, Endo S, Monguchi Y, Takekoshi Y, Ikari A, Matsunaga T.
Protective effect of aldo-keto reductase 1B1 against neuronal cell damage elicited by 4'-fluoro-α-pyrrolidinononanophenone.
Neurotox. Res. 39(4):1360-1371.

Endo S, Kawai M, Hoshi M, Segawa J, Fujita M, Matsukawa T, Fujimoto N, Matsunaga T, Ikari A.
Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells.
J. Biochem. 170(1):89-96.

Hirota C, Takashina Y, Ikumi N, Ishizuka N, Hayashi H, Tabuchi Y, Yoshino Y, Matsunaga T, Ikari A.
Inverse regulation of claudin-2 and -7 expression by p53 and hepatocyte nuclear factor 4α in colonic MCE301 cells.
Tissue Barriers. 9(1):1860409.

Morikawa Y, Miyazono H, Sakai Y, Suenami K, Sasajima Y, Sato K, Takekoshi Y, Monguchi Y, Ikari A, Matsunaga T.
4'‑Fluoropyrrolidinononanophenone elicits neuronal cell apoptosis through elevating production of reactive oxygen and nitrogen species.
Forensic Toxicol. 39:123-133.

Eguchi H, Matsunaga H, Onuma S, Yoshino Y, Matsunaga T, Ikari A.
Down-regulation of claudin-2 expression by cyanidin-3-glucoside enhances sensitivity to anticancer drugs in the spheroid of human lung adenocarcinoma A549 cells.
Int. J. Mol. Sci. 22(2):499.

Endo S, Matsunaga T, Hara A.
Characterization of aldo-keto reductase 1C subfamily members encoded in two rat genes (akr1c19 and RGD1564865). Relationship to 9-hydroxyprostaglandin dehydrogenase.
Arch. Biochem. Biophys. 700:108755.

Tatematsu K, Miyazawa D, Saito Y, Okuyama H, Ohara N.
Fully hydrogenated canola oil extends lifespan in stroke-prone spontaneously hypertensive rats.
Lipids Health Dis. 20(1):102.

2020年

Matsunaga T, Okumura N, Saito H, Morikawa Y, Suenami K, Hisamatsu A, Endo S, Ikari A.
Significance of aldo-keto reductase 1C3 and ATP-binding cassette transporter B1 in gain of irinotecan resistance in colon cancer cells.
Chem. Biol. Interact. 332:109295.

Kobayashi M, Shu S, Marunaka K, Matsunaga T, Ikari A.
Weak ultraviolet B enhances the mislocalization of Claudin-1 mediated by nitric oxide and peroxynitrite production in human keratinocyte-derived HaCaT cells.
Int. J. Mol. Sci. 21(19):7138.

Endo S, Oguri H, Segawa J, Kawai M, Hu D, Xia S, Okada T, Irie K, Fujii S, Gouda H, Iguchi K, Matsukawa T, Fujimoto N, Nakayama T, Toyooka N, Matsunaga T, Ikari A.
Development of novel AKR1C3 inhibitors as new potential treatment for castration-resistant prostate cancer.
J. Med. Chem. 63(18):10396-10411.

Nasako H, Takashina Y, Eguchi H, Ito A, Ishikawa Y, Matsunaga T, Endo S, Ikari A.
Increase in toxicity of anticancer drugs by PMTPV, a claudin-1-binding peptide, mediated via down-regulation of claudin-1 in human lung adenocarcinoma A549 cells.
Int. J. Mol. Sci. 21(16):5909.

Eguchi H, Matsunaga T, Endo S, Ichihara K, Ikari A.
Kaempferide enhances chemosensitivity of human lung adenocarcinoma A549 cells mediated by the decrease in phosphorylation of Akt and claudin-2 expression.
Nutrients. 12(4):1190.

Hara A, Nishinaka T, Abe N, El-Kabbani O, Matsunaga T, Endo S.
Dimeric dihydrodiol dehydrogenase is an efficient primate 1,5-anhydro-D-fructose reductase.
Biochem. Biophys. Res. Commun. 526(3):728-732.

Takashina Y, Ishizuka N, Ikumi N, Hayashi H, Manabe A, Hirota C, Tabuchi Y, Matsunaga T, Ikari A.
Upregulation of claudin-7 expression by angiotensin ii in colonic epithelial cells of mice fed with NaCl-depleted diets.
Int. J. Mol. Sci. 21(4):1442.

Endo S, Morikawa Y, Kudo Y, Suenami K, Matsunaga T, Ikari A, Hara A.
Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids.
J. Steroid Biochem. Mol. Biol. 199:105586.

Nasako H, Akizuki R, Takashina Y, Ishikawa Y, Shinoda T, Shirouzu M, Asai T, Matsunaga T, Endo S, Ikari A.
Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells.
Biochim. Biophys. Acta. Mol. Cell Res. 1867(4):118642.

2019年

Endo S, Matsuoka T, Nishiyama T, Arai Y, Kashiwagi H, Abe N, Oyama M, Matsunaga T, Ikari A.
Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells.
Nutr. Res. 72:92-104.

Matsunaga T, Kawabata S, Yanagihara Y, Kezuka C, Kato M, Morikawa Y, Endo S, Chen H, Iguchi K, Ikari A.
Pathophysiological roles of autophagy and aldo-keto reductases in development of doxorubicin resistance in gastrointestinal cancer cells.
Chem. Biol. Interact. 314:108839.

Maruhashi R, Eguchi H, Akizuki R, Hamada S, Furuta T, Matsunaga T, Endo S, Ichihara K, Ikari A.
Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells.
Sci. Rep. 9(1):13753.

Endo S, Matsunaga T, Hara A.
Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.
Arch. Biochem. Biophys. 674:108096.

Endo, S., Uchibori, M., Suyama, M., Arai, Y., Hu, D., Xia, S., Ma, B., Kabir, A., Kamatari, O.Y., Kuwata, K., Toyooka, N., Matsunaga T., Ikari, A.
Novel Atg4B inhibitors potentiate cisplatin therapy in lung cancer cells through blockade of autophagy.
Comput. Toxicol. 12, 100095:2019

Marunaka K, Kobayashi M, Shu S, Matsunaga T, Ikari A.
Brazilian green propolis rescues oxidative stress-induced mislocalization of claudin-1 in human keratinocyte-derived HaCaT cells.
Int. J. Mol. Sci. (16): 3869.

Marunaka K, Fujii N, Kimura T, Furuta T, Hasegawa H, Matsunaga T, Endo S, Ikari A.
Rescue of tight junctional localization of a claudin-16 mutant D97S by antimalarial medicine primaquine in Madin-Darby canine kidney cells.
Sci. Rep. 9(1):9647.

Endo S, Miyagi N, Matsunaga T, Ikari A.
Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11.
Chem. Biol. Interact. 225;305:12-20.

Manabe A, Furukawa C, Hasegawa H, Matsunaga T, Endo S, Ikari A.
Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells.
J. Cell Physiol. 234(6):8951-8962.

Matsunaga T, Tsuchimura S, Azuma N, Endo S, Ichihara K, Ikari A.
Caffeic acid phenethyl ester potentiates gastric cancer cell sensitivity to doxorubicin and cisplatin by decreasing proteasome function.
Anticancer Drugs. 30(3):251-259.

Akizuki R, Eguchi H, Endo S, Matsunaga T, Ikari A.
ZO-2 suppresses cell migration mediated by a reduction in matrix metalloproteinase 2 in claudin-18-expressing lung adenocarcinoma A549 cells.
Biol. Pharm. Bull. 42(2):247-254.

2018年

Morikawa Y, Shibata A, Sasajima Y, Suenami K, Sato K, Takekoshi Y, Endo S, Ikari A, Matsunaga T.
Sibutramine facilitates apoptosis and contraction of aortic smooth muscle cells through elevating production of reactive oxygen species.
Eur. J. Pharmacol. 841:113-121.

Eguchi H, Akizuki R, Maruhashi R, Tsukimoto M, Furuta T, Matsunaga T, Endo S, Ikari A.
Increase in resistance to anticancer drugs involves occludin in spheroid culture model of lung adenocarcinoma A549 cells.
Sci. Rep. 8(1):15157.

Takashina Y, Manabe A, Hasegawa H, Matsunaga T, Endo S, Ikari A.
Sodium citrate increases expression and flux of Mg2+ transport carriers mediated by activation of MEK/ERK/c-Fos pathway in renal tubular epithelial cells.
Nutrients.10(10):1345.

Yajima S, Shimauchi A, Sakai C, Yokoyama S, Ino Y, Matsunaga T, Teramachi H, Nakamura M, Iguchi K.
Survey of the distribution of community pharmacists using government statistics.
Yakugaku Zasshi. 138(7):991-1000.

Sonoki H, Tanimae A, Furuta T, Endo S, Matsunaga T, Ichihara K, Ikari A.
Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells.
J. Nutr. Biochem. 56:205-214.

Akizuki R, Maruhashi R, Eguchi H, Kitabatake K, Tsukimoto M, Furuta T, Matsunaga T, Endo S, Ikari A.
Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells.
Biochim. Biophys. Acta. 1865(5):769-780.

Endo S, Hoshi M, Matsunaga T, Inoue T, Ichihara K, Ikari A.
Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis.
Biochem. Biophys. Res. Commun. 497(1):437-443.

Maruhashi R, Akizuki R, Sato T, Matsunaga T, Endo S, Yamaguchi M, Yamazaki Y, Sakai H, Ikari A.
Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models
Biochim. Biophys. Acta. 1865:470-479.

Matsunaga T, Kamase K, Takasawa H, Yamaji Y, Endo S, El-Kabbani O, Ikari A.
Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1.
Chem. Biol. Interact. 279:10-20.