Field of Study
skin science, investigative dermatology, cell biology
hyaluronic acid, keratinocyte, pigmentation, fibroblast
Contribute to achieve "Beauty and Health"
  • 特任教授 井上 紳太郎 Research Professor Inoue Shintaro Ph.D. inoshin
  • 特任教授 アルナシリ・イダマルゴダ Research Professor Arunasiri Iddamalgoda Ph.D.
  • 特任准教授 水谷 有紀子 Research Associate Professor Mizutani Yukiko Ph.D. mizutani

研究テーマ Research Subjects

  医療の著しい進歩や生活環境(ライフスタイル)の改善により長寿社会となった今日、長生きするだけでなく「生活の質」あるいは「人生の質」(QOL:Quality of Life)を高めることが求められている。健康であることは勿論のこと、とりわけ若々しく美しく見えることが、人をより前向きにさせる重要な要素である。近年、見かけ年齢が実年齢より下回ることと健康であること(機能的に「肌を含む身体の生理的年齢」が実年齢よりも下回ること)が関連しているらしいとの報告はあるが、まだ十分に科学的に立証されていない。本講座では、全身の健康状態の変化(加齢、生活習慣病、慢性炎症、老化など)と皮膚の機能変化との関係を科学的に解明することにより、「美と健康」の実現に貢献する。また、香粧品および食品素材の機能と安全性、および利用の社会的意義(QOL の向上、予防医学)を、皮膚科学的視点で評価し、新たな価値を提案する。

Due to remarkable advances in the medical and health fields as well as improvement in the social environment and lifestyle habits, we have now entered the age of longevity, and demand a high quality of life (QOL) with a healthy long life. In addition to having a sound body and mind, another important factor for a person's well-being is to appear younger and more attractive than one actually. Recently, it has been reported that younger perceived age or estimated age is related to maintain physiological functions of one's entire body including one's skin, at levels higher than those of other people of the same age, however it remains obscure scientifically. We aim to contribute to achieve "Beauty and Health" by elucidating scientifically the relationship between changes in conditions of systemic health such as aging, lifestyle-related diseases, chronic inflammation, and senescence, and functional alterations of the skin. In addition, we propose new values of cosmetic and food ingredients by estimating function, safety, and social significance such as QOL improvement and preventive medicine in a viewpoint of skin science.


研究課題 Research Objectives

  1. 皮膚の健康や肌の美しさに影響する内因性メディエーターを探索する
    Research on endogeneous mediators related to skin health essential for skin beauty
  2. 慢性炎症と皮膚の老化の関係を in vitro 細胞培養系で明らかにする
    Clarification of the relationship between chronic inflammation and skin aging by in vitro cultured cell systems
  3. 脱色素誘導化合物の色素細胞特異的な細胞障害メカニズムを解明する
    Elucidation of mechanism for melanocyte specific cytotoxicity in chemical-induced depigmentaion

最近の研究成果 Research Results

  1. Nagata H, Inoue S, Mizutani Y., Nicotine affects tight junction barriers via alpha7 nicotine-like acetylcholine receptor in keratinocytes. J Dermatol Sci. 103: 183-185. (2021)
  2. Wang Q, Kuroda Y, Yang L, Lai S, Mizutani Y, Iddamalgoda A, Guo J,Yamamoto A, Murase D, Takahashi Y, Xiang L, Inoue S, Tsuruta D, Katayama I., GPNMB extracellular fragment protects melanocytes from oxidative stress by inhibiting AKT phosphorylation independent of CD44. Int J Mol Sci. 22: 10843. (2021)
  3. Mizutani Y, Takagi N, Nagata H, Inoue S., Interferon- γ downregulates tight junction function, which is rescued by interleukin-17A. Exp Dermatol. 30: 1754-1763 (2021)
  4. Tsuji S, Nakamura S, Yamada T, Vega S.d, Okada Y, Inoue S, Shimazawa M, Hara H., HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth. Brain Res. 1764:147490. (2021)
  5. Sato S, Mizutani Y, Yoshino Y, Masuda M, Miyazaki M, Hara H, Inoue S., Pro-inflammatory cytokines suppress HYBID (hyaluronan (HA) - binding protein involved in HA depolymerization/KIAA1199 /CEMIP) - mediated HA metabolism in human skin fibroblasts. Biochem Biophys Res Commun. 539: 77-82. (2021)
  6. Matsunaga K, Suzuki K, Ito A, Tanemura A, Abe Y, Suzuki T, Yoshikawa M, Sumikawa Y, Yagami A, Masui Y,
    Inoue S, Ito S, Katayama I., Rhododendrol - induced leukoderma update I: Clinical findings and treatment. J Dermatol. 48: 961-968 (2021)
  7. Inoue S, Katayama I, Suzuki T, Tanemura A, Ito S, Abe Y, Sumikawa Y, Yoshikawa M, Suzuki K, Yagami A, Masui Y, Ito A, Matsunaga K. Rhododendrol-induced leukoderma update II: Pathophysiology, mechanisms, risk evaluation, and possible mechanism-based treatments in comparison with vitiligo. J Dermatol. 48:969-978. (2021)
  8. Mikami M, Takuya O, Yoshino Y, Nakamura S, Ito K, Kojima H, Takahashi T, Iddamalgoda A, Inoue S, Shimazawa M, Hara H., Acorus calamus extract and its component α-asarone attenuate murine hippocampal neuronal cell death induced by L-glutamate and tunicamycin. Biosci Biotech Biochem. 85: 493-501. (2021)